Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Expectation Modulates Human Brain Responses To Acute Cocaine: A Functional Magnetic Resonance Imaging Study, Peter Kufahl, Zhu Li, Robert C. Risinger, Charles Rainey, Linda B. Piacentine, Gaohong Wu, Alan S. Bloom, Zheng Yang, Shi-Jiang Li
Expectation Modulates Human Brain Responses To Acute Cocaine: A Functional Magnetic Resonance Imaging Study, Peter Kufahl, Zhu Li, Robert C. Risinger, Charles Rainey, Linda B. Piacentine, Gaohong Wu, Alan S. Bloom, Zheng Yang, Shi-Jiang Li
College of Nursing Faculty Research and Publications
Background
Human expectation of psychoactive drugs significantly alters drug effects and behavioral responses. However, their neurophysiological mechanisms are not clear. This study investigates how cocaine expectation modulates human brain responses to acute cocaine administration.
Methods
Twenty-six right-handed non–treatment-seeking regular cocaine abusers participated in this study. Changes in blood oxygenation level-dependent (BOLD) signals were measured, and online behavioral ratings during cocaine expectation and acute cocaine administration were recorded.
Results
Distinct regional characteristics in BOLD responses to expected and unexpected cocaine infusions were observed in the medial orbitofrontal gyrus (Brodmann area [BA] 11), frontal pole (BA 10), and anterior cingulate gyrus regions. …