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Full-Text Articles in Medicine and Health Sciences
The Cerebellar Fastigial Nucleus Contributes To Co2-H+ Ventilatory Sensitivity In Awake Goats, P. F. Martino, S. Davis, C. Opansky, Katie L. Krause, Joshua M. Bonis, Lawrence Pan, B. Qian, Hubert V. Forster
The Cerebellar Fastigial Nucleus Contributes To Co2-H+ Ventilatory Sensitivity In Awake Goats, P. F. Martino, S. Davis, C. Opansky, Katie L. Krause, Joshua M. Bonis, Lawrence Pan, B. Qian, Hubert V. Forster
Physical Therapy Faculty Research and Publications
The purpose of this study was to test the hypothesis that an intact cerebellar fastigial nucleus (CFN) is an important determinant of CO2-H+ sensitivity during wakefulness. Bilateral, stainless steel microtubules were implanted into the CFN (N = 9) for injection (0.5–10 μl) of the neurotoxin ibotenic acid. Two or more weeks after implantation of the microtubules, eupneic breathing and CO2-H+ sensitivity did not differ significantly (P > 0.10) from pre-implantation conditions. Injection of ibotenic acid (50 mM) did not significantly alter eupneic PaCO2 (P > 0.10). The coefficient of variation of …