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Meperidine Attenuates The Secretion But Not The Transcription Of Il-1ss In Human Mononuclear Leukocytes, Donna O. Mccarthy, Susan Murray, Dawn Galagan, James E. Gern, Paul R. Hutson
Meperidine Attenuates The Secretion But Not The Transcription Of Il-1ss In Human Mononuclear Leukocytes, Donna O. Mccarthy, Susan Murray, Dawn Galagan, James E. Gern, Paul R. Hutson
College of Nursing Faculty Research and Publications
Background: The infusion of amphotericin-B (AmB) often produces clinically distressing rigors and chills, which promptly abate with intravenous injection of meperidine, although its mechanism of action is unknown.
Objective: To examine the effects of meperidine on the transcription or secretion of Interleukin 1β (IL-1β) in human mononuclear leukocytes (MNL) exposed in vitro to the lipopolysaccharide (LPS) contained inEscherichia coli endotoxin or to AmB.
Methods: Blood was drawn from eight healthy adult volunteers. The blood was centrifuged, and the layer containing MNL was separated; incubated with various combinations of medium, meperidine, and AmB; then tested for IL-1 content to determine …