Medicine and Health Sciences Commons^™

Role Of Peptide Backbone Conformation On Biological Activity Of Chemotactic Peptides, Andrew R. Dentino, Periathamby A. Raj, Krishna K. Bhandary, Mark E. Wilson, Michael J. Devine

School of Dentistry Faculty Research and Publications

To investigate the role of peptide backbone conformation on the biological activity of chemotactic peptides, we synthesized a unique analog of N-formyl-Met-Leu-Phe-OH incorporating the C ^α,α disubstituted residue, dipropylglycine (Dpg) in place of Leu. The conformation of the stereochemically constrained Dpg analog was examined in the crystalline state by x-ray diffraction and in solution using NMR, IR, and CD methods. The secretagogue activity of the peptide on human neutrophils was determined and compared with that of a stereochemically constrained, folded type II β-turn analog incorporating 1-aminocyclohexanecarboxylic acid (Ac₆c) at position 2 (f-Met- Ac₆c -Phe-OMe), the …

Chronic Dermal Ulcer Healing Enhanced With Monophasic Pulsed Electrical Stimulation, Jeffery A. Feedar, Luther C. Kloth, Gary D. Gentzkow

Physical Therapy Faculty Research and Publications

The purposes of this randomized, double-blind, multicenter study were to compare healing of chronic dermal ulcers treated with pulsed electrical stimulation with healing of similar wounds treated with sham electrical stimulation and to evaluate patient tolerance to the therapeutic protocol. Forty-seven patients, aged 29 to 91 years, with 50 stage II, III, and IV ulcers were randomly assigned to either a treatment group (n=26) or a control (sham treatment) group (n=24). Treated wounds received 30 minutes of pulsed cathodal electrical stimulation twice daily at a pulse frequency of 128 pulses per second (pps) and a peak amplitude of 29.2 mA …

Improved Healing Of Pressure Ulcers Using Dermapulse, A New Electrical Stimulation Device, Gary D. Gentzkow, Sheldon V. Pollack, Luther C. Kloth, Harrison A. Stubbs

Physical Therapy Faculty Research and Publications

A double-blind, clinical study of pulsed electrical stimulation using the Dermapulse® device was carried out on 40 pressure ulcers, randomized to receive either active (stim) or sham treatment.

Electrodes were placed over saline-moistened gauze on the ulcers. An electrical current of 35mA was delivered to the wound tissues at a frequency of 128 pulses per second. Polarity was negative until the wound debrided, then alternated from .positive to negative every three days. Ulcers were treated for 30 minutes twice daily for four weeks, after which sham patients could cross over to active treatment, and stim patients could continue active treatment. …

Multinational Validation Of Anxiety, Hopelessness, And Ineffective Airway Clearance, Richard Fehring, Teresa Fadden, Madeline Wake

College of Nursing Faculty Research and Publications

The effective use of nursing diagnosis internationally depends in part on incorporating language and cultural difference into the common language of nursing. International validation studies can provide a basis for this effort. This study tested three diagnoses—anxiety, hopelessness, and ineffective airway clearance—through multinational validation. The Diagnostic Content Validity (DCV) model was used to collect data from critical care nurses in six countries. Defining characteristics rated as critical (> .80) by the total sample were dyspnea for ineffective airway clearance and panic and nervousness for anxiety. No critical defining characteristics for hopelessness were identified. DCV ratios for …

Tympanic Infrared Thermometry For Fullterm And Preterm Neonates, Marianne Weiss

College of Nursing Faculty Research and Publications

Tympanic infrared thermometry has been proposed as a safe, rapid, cost-effective, and reliable method of temperature taking. 1,2 Testing with adults and children have produced results supporting its use in clinical practice. In previous studies conducted with an adult population, excellent results for accuracy and precision were obtained.^3,4 Studies of children have primarily focused on the use of tympanic thermometry for use in pediatric office and emergency room settings.^5~6 Kenney et al.1 found tympanic thermometry to differ from rectal temperature by .06°C across all ages and by .02°C for subjects less than two months of age. Mean differences …

Matters Arising: Bhatnagar And Andy Reply, Subhash Bhatnagar, Orlando J. Andy

Speech Pathology and Audiology Faculty Research and Publications

No abstract provided.

Integrating Ethics Into The Nursing Curriculum, Margaret Sebern

College of Nursing Faculty Research and Publications

No abstract provided.