Energy Cost Of Slow And Normal Gait Speeds In Low And Normally Functioning Adults, Taylor W. Rowley, Chi Cho, Ann M. Swartz, John Staudenmayer, Allison S. Hyngstrom, Kevin G. Keenan, Whitney A. Welch, Scott J. Strath

Physical Therapy Faculty Research and Publications

Objective

Slow walking speed paired with increased energy cost is a strong predictor for mortality and disability in older adults but has yet to be examined in a heterogeneous sample (ie, age, sex, disease status). The aim of this study was to examine energy cost of slow and normal walking speeds among low- and normal-functioning adults.

Design

Adults aged 20–90 yrs were recruited for this study. Participants completed a 10-m functional walk test at a self-selected normal walking speed and were categorized as low functioning or normal functioning based on expected age- and sex-adjusted average gait speed. Participants completed two …

Practical Guidance For Engaging Patients In Health Research, Treatment Guidelines And Regulatory Processes: Results Of An Expert Group Meeting Organized By The World Health Organization (Who) And The European Society For Clinical And Economic Aspects Of Osteoporosis, Osteoarthritis And Musculoskeletal Diseases (Esceo), Maarten De Wit, Cyrus Cooper, Peter Tugwell, Nathalie Bere, John Kirwan, Philip G. Conaghan, Charlotte Roberts, Isabelle Aujoulat, Nasser Al-Daghri, Islene Arajujo De Carvalho, Mary Barker, Nicola Bedlington, Maria Luisa Brandi, Olivier Bruyère, Nansa Burlett, Philippe Halbout, Mickaël Hiligsmann, Famida Jiwa, John A. Kanis, Andrea Laslop, Wendy Lawrence, Daniel Pinto, Concepción Prieto Yerro, Véronique Rabenda, René Rizzoli, Marieke Scholte-Voshaar, Mila Vlaskovska, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The …

Practical Guidance For Engaging Patients In Health Research, Treatment Guidelines And Regulatory Processes: Results Of An Expert Group Meeting Organized By The World Health Organization (Who) And The European Society For Clinical And Economic Aspects Of Osteoporosis, Osteoarthritis And Musculoskeletal Diseases (Esceo), Maarten De Wit, Cyrus Cooper, Peter Tugwell, Nathalie Bere, John Kirwan, Philip G. Conaghan, Charlotte Roberts, Isabelle Aujoulat, Nasser Al-Daghri, Islene Arajujo De Carvalho, Mary Barker, Nicola Bedlington, Maria Luisa Brandi, Olivier Bruyère, Nansa Burlett, Philippe Halbout, Mickaël Hiligsmann, Famida Jiwa, John A. Kanis, Andrea Laslop, Wendy Lawrence, Daniel Pinto, Concepción Prieto Yerro, Véronique Rabenda, René Rizzoli, Marieke Scholte-Voshaar, Mila Vlaskovska, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The …

Does Weight Status Impact Metabolic Health In Adolescents When Controlling For Physical Fitness?, Stacy Stolzman, Joseph Skelton, April L. Harkins, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

Purpose:

To determines whether adolescents who are fit with overweight/obesity are similar in their metabolic profile to adolescents who are fit and normal weight.

Methods:

Adolescents participated in 3 sessions: (1) resting vitals and anthropometrics; (2) maximal aerobic treadmill test () to determine physical fitness; and (3) dual-energy x-ray absorptiometry and fasting laboratory draw for analysis of insulin, glucose, high-density lipoprotein, triglycerides, and C-reactive protein.

Results:

Of the 30 fit adolescents who are normal weight and 16 adolescents who are fit and overweight/obese (OW/OB), metabolic syndrome was apparent in 1 adolescent who are normal weight and 4 adolescents who are …

The Effect Of A Portable Electrical Muscle Stimulation Device At Home On Muscle Strength And Activation Patterns In Locomotive Syndrome Patients: A Randomized Control Trial, Yuichi Nishikawa, Kohei Watanabe, Shuhei Kawade, Tetsuya Takahashi, Hiroaki Kimura, Hirofumi Maruyama, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

The aim of the present study was to quantify the effect of electrical muscle stimulation (EMS) intervention using a portable device on muscle strength and activation patterns in locomotive syndrome. Nineteen women were randomly assigned to the intervention group (n = 10; age = 71–82 years) and control group (n = 9; age = 70–84 years). Participants in the intervention group used a portable EMS device to stimulate the bilateral quadriceps muscles for 8 weeks (23 min/5 days/week). To understand the effects of EMS, the following measurements were made at baseline, 8 weeks, and 12 weeks: locomotive syndrome assessment score, …

Fatiguing Trunk Flexor Exercise Decreases Pain Sensitivity In Postpartum Women, Rita Deering, Tatyana Pashibin, Meredith Cruz, Sandra K. Hunter, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

Background: Low back pain (LBP) is common in the general population and among postpartum women. Abdominal muscle exercise is often used to treat LBP, but it is unknown if fatiguing abdominal muscle exercise can produce exercise-induced hypoalgesia (EIH).

Objectives: To assess pressure pain thresholds (PPTs) at rest and following fatiguing trunk flexor exercise (EIH) in (1) nulligravid and postpartum women to evaluate the impact of pregnancy and childbirth and (2) nulligravid women and men to examine sex differences.

Methods: Seventy healthy adults (31 postpartum women, 23 nulligravid women, 16 men) participated. Postpartum and nulligravid women were tested twice (16–18 weeks …

Two Weeks Of Ischemic Conditioning Improves Walking Speed And Reduces Neuromuscular Fatigability In Chronic Stroke Survivors, Matthew J. Durand, Timothy F. Boerger, Jennifer Nguyen, Saad Z. Alqahtani, Michael T. Wright, Brian D. Schmit, David D. Gutterman, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

This pilot study examined whether ischemic conditioning (IC), a noninvasive, cost-effective, and easy-to-administer intervention, could improve gait speed and paretic leg muscle function in stroke survivors. We hypothesized that 2 wk of IC training would increase self-selected walking speed, increase paretic muscle strength, and reduce neuromuscular fatigability in chronic stroke survivors. Twenty-two chronic stroke survivors received either IC or IC Sham on their paretic leg every other day for 2 wk (7 total sessions). IC involved 5-min bouts of ischemia, repeated five times, using a cuff inflated to 225 mmHg on the paretic thigh. For IC Sham, the cuff inflation …

Incremental Clinical Effectiveness And Cost Effectiveness Of Providing Supervised Physiotherapy In Addition To Usual Medical Care In Patients With Osteoarthritis Of The Hip Or Knee: 2-Year Results Of The Moa Randomised Controlled Trial, J. H. Abbott, R Wilson, Daniel Pinto, C. M. Chapple, A. A. Wright

Physical Therapy Faculty Research and Publications

Objective

To investigate the clinical- and cost-effectiveness at 2-year follow-up of providing individual, supervised exercise physiotherapy and/or manual physiotherapy in addition to usual medical care.

Method

People with hip or knee osteoarthritis meeting the American College of Rheumatology clinical diagnostic criteria were randomised (1:1, concealed, assessor-blinded) to four groups: usual medical care; supervised exercise physiotherapy; manual physiotherapy; or combined exercise and manual physiotherapy. Physiotherapy group participants were provided 10 50-min treatment sessions including booster sessions at 4 and 13 months, in addition to usual care. The primary outcome at 2-year follow-up was incremental cost-utility ratio (ICUR) of each physiotherapy intervention …

Preferences For Physical Activity: A Conjoint Analysis Involving People With Chronic Knee Pain, Daniel Pinto, Ulf Bockenholt, Jungwha Lee, Rowland W. Chang, Leena Sharma, Daniel J. Finn, Allen W. Heinemann, Jane Louise Holl, Paul D. Hansen

Physical Therapy Faculty Research and Publications

Objective

To investigate individual preferences for physical activity (PA) attributes in adults with chronic knee pain, to identify clusters of individuals with similar preferences, and to identify whether individuals in these clusters differ by their demographic and health characteristics.

Design

An adaptive conjoint analysis (ACA) was conducted using the Potentially All Pairwise RanKings of all possible Alternatives (PAPRIKA) method to determine preference weights representing the relative importance of six PA attributes. Cluster analysis was performed to identify clusters of participants with similar weights. Chi-square and ANOVA were used to assess differences in individual characteristics by cluster. Multinomial logistic regression was …

A Principal Components Analysis Approach To Quantifying Foot Clearance And Foot Clearance Variability, Lauren C. Benson, Stephen C. Cobb, Allison S. Hyngstrom, Kevin G. Keenan, Jake Luo, Kristian M. O'Connor

Physical Therapy Faculty Research and Publications

Low foot clearance and high variability may be related to falls risk. Foot clearance is often defined as the local minimum in toe height during swing; however, not all strides have this local minimum. The primary purpose of this study was to identify a nondiscrete measure of foot clearance during all strides, and compare discrete and nondiscrete measures in ability to rank individuals on foot clearance and variability. Thirty-five participants (young adults [n = 10], older fallers [n = 10], older nonfallers [n = 10], and stroke survivors [n = 5]) walked overground while lower extremity 3D kinematics were recorded. …

Brain Activation During Passive And Volitional Pedaling After Stroke, Brice T. Cleland, Sheila M. Schindler-Ivens

Physical Therapy Faculty Research and Publications

Background: Prior work indicates that pedaling-related brain activation is lower in people with stroke than in controls. We asked whether this observation could be explained by between-group differences in volitional motor commands and pedaling performance. Methods: Individuals with and without stroke performed passive and volitional pedaling while brain activation was recorded with functional magnetic resonance imaging. The passive condition eliminated motor commands to pedal and minimized between-group differences in pedaling performance. Volume, intensity, and laterality of brain activation were compared across conditions and groups. Results: There were no significant effects of condition and no Group × Condition …

Clinical Decision-Making For Thrombolysis Of Acute Minor Stroke Using Adaptive Conjoint Analysis, Ava L. Liberman, Daniel Pinto, Sara K. Rostanski, Daniel L. Labovitz, Andrew M. Naidech, Shyam Prabhakaran

Physical Therapy Faculty Research and Publications

Introduction:

There is practice variability in the treatment of patients with minor ischemic stroke with thrombolysis. We sought to determine which clinical factors physicians prioritize in thrombolysis decision-making for minor stroke using adaptive conjoint analysis.

Methods:

We conducted our conjoint analysis using the Potentially All Pairwise RanKings of all possible Alternatives methodology via the 1000Minds platform to design an online preference survey and circulated it to US physicians involved in stroke care. We evaluated 6 clinical attributes: language/speech deficits, motor deficits, other neurological deficits, history suggestive of increased risk of complication from thrombolysis, age, and premorbid disability. Survey participants were …

Recommendations For The Conduct Of Economic Evaluations In Osteoporosis: Outcomes Of An Experts’ Consensus Meeting Organized By The European Society For Clinical And Economic Aspects Of Osteoporosis, Osteoarthritis And Musculoskeletal Diseases (Esceo) And The Us Branch Of The International Osteoporosis Foundation, M. Hiligsmann, J.-Y. Reginster, A.N.A. Tosteson, S.V. Bukata, K.G. Saag, D.T. Gold, P. Halbout, F. Jiwa, E.M. Lewiecki, Daniel Pinto, J.D. Adachi, N. Al-Daghri, O. Bruyère, M. Chandran, C. Cooper, N.C. Harvey, T.A. Einhorn, J.A. Kanis, D.L. Kendler, O.D. Messina, R. Rizzoli, L. Si, S. Silverman

Physical Therapy Faculty Research and Publications

Summary

Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct, and reporting of economic evaluations in osteoporosis to improve their transparency, comparability, and methodologic standards.

Introduction

This paper aims to provide recommendations for the conduct of economic evaluations in osteoporosis in order to improve their transparency, comparability, and methodologic standards.

Methods

A working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis to make recommendations for the design, conduct, …

Patients’ Preferences For Osteoarthritis Treatment: The Value Of Stated-Preference Studies, Mickael Hiligsmann, Daniel Pinto, Elaine Dennison, Nasser Al-Daghri, Charlotte Beaudart, Jaime Branco, Olivier Bruyère, Philip G. Conaghan, Cyrus Cooper, Gabriel Herrero-Beaumont, Famida Jiwa, Willem Lems, Thierry Thomas, Nicola Veronese, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

No abstract provided.