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Histological And Immunohistochemical Evaluation Of Biphasic Calcium Phosphate And A Mineral Trioxide Aggregate For Bone Healing In Rat Calvaria, Luis Gustavo Régio De Carvalho Silva, Sung Hyun Kim, Sônia Mara Luczyszyn, Allan Giovanini, Luis Eduardo Almeida, Vinícius Augusto Tramontina

School of Dentistry Faculty Research and Publications

This work focused on the process of bone repair of defects in standardized calvaria of Wistar rats treated with biphasic calcium phosphate (BCP), mineral trioxide aggregate (MTA), or a combination of the two. Eighty Wistar rats were divided into four treatment groups and were examined at 2 and 8 weeks. A surgical defect was created in the calvaria using a 6-mm diameter trephine drill. The cavity was treated with BCP, MTA, or BCP + MTA; untreated rats with clot formation served as controls. Samples were evaluated histologically and by immunohistochemical staining for areas of new osteoid tissue and new bone …