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The Roles Of Inflammation, Oxidative Stress, And Neurotransmitters In An Animal Model Of Post-Traumatic Stress Disorder, Carl Brad Wilson
The Roles Of Inflammation, Oxidative Stress, And Neurotransmitters In An Animal Model Of Post-Traumatic Stress Disorder, Carl Brad Wilson
LSU Doctoral Dissertations
Post-traumatic stress disorder (PTSD), a trauma- and stressor-related disorder, is a condition that can develop in response to life-threatening situations. According to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5), a diagnosis of PTSD necessitates exposure to a life-threatening event, intrusive recollections, avoidance of associated stimuli, hyperarousal, and a significant social impairment. All of these symptoms must persist for at least 30 days and not be due to illness, medication, or substance abuse. To date, no definitive diagnostic biomarkers have been identified for PTSD. Recent research, however, points toward physiological abnormalities in the brain, hypothalamic-pituitary-adrenal (HPA) axis, and …