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Acute Myelomonocytic Leukemia, Acute Promyelocytic Leukemia, Tetrasomy 8
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Full-Text Articles in Medicine and Health Sciences
Acute Myelomonocytic Leukemia With Tetrasomy 8: Histologic And Immunophenotypic Features Mimicking Acute Promyelocytic Leukemia, Amar Jariwala, Donald S. Karcher
Acute Myelomonocytic Leukemia With Tetrasomy 8: Histologic And Immunophenotypic Features Mimicking Acute Promyelocytic Leukemia, Amar Jariwala, Donald S. Karcher
Pathology Faculty Publications
Rare cases of acute myeloid leukemia (AML) with tetrasomy 8 have been reported. Tetrasomy 8, a poor prognostic factor, has been predominantly associated with AML with monocytic differentiation. We report an unusual case of acute myelomonocytic leukemia (AMML) with tetrasomy 8 showing histologic and immunophenotypic features mimicking acute promyelocytic leukemia (APL). The patient is a 63-year-old African American man with molar pain, gum swelling and bleeding, generalized fatigue, leukocytosis, anemia, and thrombocytopenia. A peripheral blood smear showed increased white cells with many immature granulocytic forms. Approximately 40% of the cells exhibited classical blast morphology, 40% were slightly enlarged and exhibited …