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Full-Text Articles in Medicine and Health Sciences
Effect Of Direct-Acting Antiviral Agents On Hepatitis C Virus-Associated Thrombocytopenia, Alaa E. Abdelhamid, Aly M. El-Kholy, Essam A. Abdelmohsen, Hasan A. Zagla, Mohamed A. Abdelhafez, Sabry A. Shoeib, Zeinab A. A. Kasemy
Effect Of Direct-Acting Antiviral Agents On Hepatitis C Virus-Associated Thrombocytopenia, Alaa E. Abdelhamid, Aly M. El-Kholy, Essam A. Abdelmohsen, Hasan A. Zagla, Mohamed A. Abdelhafez, Sabry A. Shoeib, Zeinab A. A. Kasemy
Menoufia Medical Journal
Objectives To evaluate the effect of direct-acting antiviral agents (DAAs) on hepatitis C virus (HCV)-associated thrombocytopenia. Background The prevalence of thrombocytopenia in HCV infection ranged from 0.16 to 45.4%. The pathophysiology of HCV-associated thrombocytopenia is poorly understood and multifactorial. Cellular immunity has an important role. Antiplatelet antibodies are common. Production of thrombopoietin may be reduced. Infection of megakaryocytes with HCV may impair platelet production. Clearance of HCV with DAA is expected to restore innate functions of the hepatocytes and immune system reconstitution. Patients and methods This was a prospective study on 104 patients with HCV-associated thrombocytopenia receiving DAA (sofosbuvir and …
The Influence Of Phototherapy For Neonatal Hyperbilirubinemia On Tumour Necrosis Factor-Α, Magdy A. Saber, Mohamed A. Helwa, Ramy N. Deghedy, Sameh A. Abd El Naby
The Influence Of Phototherapy For Neonatal Hyperbilirubinemia On Tumour Necrosis Factor-Α, Magdy A. Saber, Mohamed A. Helwa, Ramy N. Deghedy, Sameh A. Abd El Naby
Menoufia Medical Journal
Objective The aim of the study was to investigate the influence of phototherapy in treatment of neonatal hyperbilirubinemia on the serum level of tumour necrosis factor-α (TNF-α). Background Jaundice is the most common clinical diagnosis in neonatal medicine that requires medical attention. Phototherapy is the most commonly used intervention to treat and prevent severe hyperbilirubinemia. Some investigations have expressed concern about potential toxic effects of phototherapy; one possible harmful consequence is affection of cytokines production and lymphocyte subtypes, which can affect the function of the immune system of the newborn. Recent research has provided evidence that phototherapy is associated with …