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Full-Text Articles in Medicine and Health Sciences
The Protective Effect Of Metformin And Exenatide On Doxorubicin-Induced Nephrotoxicity In Rats, Eman A. Ali, Maha M. El-Batsh, Manal A. E. Safan, Marwa M. Serag El-Dien, Safa R. El Fiky
The Protective Effect Of Metformin And Exenatide On Doxorubicin-Induced Nephrotoxicity In Rats, Eman A. Ali, Maha M. El-Batsh, Manal A. E. Safan, Marwa M. Serag El-Dien, Safa R. El Fiky
Menoufia Medical Journal
Objective The aim was to study the protective effect of metformin and exenatide on doxorubicin (DOX)-induced nephrotoxicity in rats. Background DOX is an effective chemotherapeutic agent used for treatment of various solid as well as hematological neoplasms. Its use is limited owing to well-documented nephrotoxicity. Treatment with metformin and exenatide ameliorates nephrotoxicity in rats through antioxidant and antiapoptotic effects. Materials and methods In this experimental study, rats were divided as follows: group 1 was injected with saline intraperitoneal and orally, group 2 was injected with intraperitoneal DOX (15 mg/kg) and oral saline, group 3 was injected with intraperitoneal DOX and …
Possible Protective Effects Of Quercetin On Doxorubicin-Induced Cardiotoxicity In Rats, Fatma E. R. Hashish, Maha M. Elbatsh, Mahmoud H. El-Odemi, Moshira M. Abdel-Wahed, Sherin S. El-Naidany
Possible Protective Effects Of Quercetin On Doxorubicin-Induced Cardiotoxicity In Rats, Fatma E. R. Hashish, Maha M. Elbatsh, Mahmoud H. El-Odemi, Moshira M. Abdel-Wahed, Sherin S. El-Naidany
Menoufia Medical Journal
Objective Our study aimed to investigate the possible protective effects of quercetin (QCT) on doxorubicin (DOX)-induced cardiotoxicity in rats. Background DOX is an antineoplastic drug that produces cardiotoxicity; it generates highly cytotoxic-free radicals that damage the cardiomyocytes. QCT is a plant flavonoid. QCT pretreatment reduces DOX-induced oxidative stress. Materials and methods Fifty-five adult rats were divided into four groups: group 1 (control) received saline (5 ml/kg) orally for 4 weeks; group 2 (DOX) received six doses of DOX intraperitoneally (2.5 mg/kg) on alternative days in the last 2 weeks; group 3 (QCT + DOX) received QCT orally (10 mg/kg once …
P53 As An Apoptotic Marker Before And After Phototherapy In Hyperbilirubinemic Neonates, Amr A. Alkorashy, Belal A. Montaser, Gehan K. Sead, Thoria A. Omar, Zain A. Omar
P53 As An Apoptotic Marker Before And After Phototherapy In Hyperbilirubinemic Neonates, Amr A. Alkorashy, Belal A. Montaser, Gehan K. Sead, Thoria A. Omar, Zain A. Omar
Menoufia Medical Journal
Objective The objective of this study was to study the serum level of p53 before, during, and after phototherapy in full-term neonates with hyperbilirubinemia and to confirm that p53 is an apoptotic marker related to phototherapy. Background Jaundice is a serious condition that can lead to death or lifelong neurological sequela in newborns, so it requires medical attention. Phototherapy is the standard treatment for neonatal hyperbilirubinemia; however, it led to potential side effects such as retinal degeneration, diarrhea, dehydration, and skin rash. Experimental studies demonstrated that phototherapy increased apoptosis in lymphoma cell line and neonatal small intestine cells. p53 is …
Evaluation Of Survivin Gene Expression As A Prognostic Biomarker In Pediatric B-Acute Lymphoblastic Leukemia, Ayman Azzam, Fathia Elbassal, Mahmoud A. El-Hawy, Nagwan Y. Saleh, Samar M. Kamal Elden
Evaluation Of Survivin Gene Expression As A Prognostic Biomarker In Pediatric B-Acute Lymphoblastic Leukemia, Ayman Azzam, Fathia Elbassal, Mahmoud A. El-Hawy, Nagwan Y. Saleh, Samar M. Kamal Elden
Menoufia Medical Journal
Objective The aim of this study was to evaluate the level of survivin mRNA expression in Egyptian patients with acute pediatric lymphoblastic leukemia and to outline any significant relation between the level of survivin expression and the clinical and hematological findings in those patients. Background Survivin, a unique member of the inhibitor of apoptosis protein family, plays an important role in regulating both apoptosis and cell division and was found to be highly expressed in various kinds of tumors. Patients and methods Survivin expression was quantitatively determined by real-time (RT) PCR in 30 newly diagnosed acute lymphoblastic leukemia (B-ALL) pediatric …
Caspase-3 Expression In Lichen Planus, Alaa H. Maraeea, Eman A. Zaky, Hala S. El-Rebey
Caspase-3 Expression In Lichen Planus, Alaa H. Maraeea, Eman A. Zaky, Hala S. El-Rebey
Menoufia Medical Journal
Objective: The aim of this study was to examine keratinocyte apoptosis and caspase-3 expression in lichen planus (LP). Background: Caspase-3 expression level in LP lesions is considered a reliable marker of apoptosis, which is frequently found in LP, but the pathways leading to apoptosis are unknown. Patients and methods: A total of 25 skin biopsy specimens from LP lesions were used and 17 healthy volunteers were used as controls. Histopathological examination of hematoxylin and eosin-stained sections of LP was carried out for the evaluation of histopathological parameters. The expression of caspase-3 was examined immunohistochemically. Results: There were highly significant differences …