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Full-Text Articles in Medicine and Health Sciences
Correlation Between Circulating Tumour Dna And Metabolic Tumour Burden In Metastatic Melanoma Patients, Ashleigh Mcevoy, Lydia Warburton, Zeyad Al-Ogaili, Leisl Celliers, Lesley Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Mel R. Ziman Dr, Elin S. Gray
Correlation Between Circulating Tumour Dna And Metabolic Tumour Burden In Metastatic Melanoma Patients, Ashleigh Mcevoy, Lydia Warburton, Zeyad Al-Ogaili, Leisl Celliers, Lesley Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Mel R. Ziman Dr, Elin S. Gray
Research outputs 2014 to 2021
Background: Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the patients' overall metabolic tumour burden (MTB). Methods: Thirty-two treatment naïve metastatic melanoma patients were included in the study. MTB and metabolic tumour volume (MTV) was measured by 18F-fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT). Plasma ctDNA was quantified using droplet digital PCR (ddPCR). Results: CtDNA was detected in 23 …
Circulating Tumour Dna: A Non-Invasive Biomarker For Melanoma, Ashleigh Cavell Mcevoy
Circulating Tumour Dna: A Non-Invasive Biomarker For Melanoma, Ashleigh Cavell Mcevoy
Theses: Doctorates and Masters
Cutaneous melanoma accounts for 90% of all skin cancer deaths (Balch et al., 2010) and is responsible for 3.6% of deaths from cancer in Australia (Australian Institute of Health and Welfare, 2016). Whilst early detection and successful surgical removal of primary melanomas have improved survival rates (DeSantis et al., 2014), approximately 30% of these patients will have disease recurrence at some point in their lives (Soong et al., 1992; Soong et al., 1998). This is despite being considered disease free following treatment, which may have included surgical removal of the primary and/or its metastasis/es, radiation and/or systemic therapy. Whilst the …