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Full-Text Articles in Medicine and Health Sciences
Pax Genes: Regulators Of Lineage Specification And Progenitor Cell Maintenance, Judith A. Blake, Mel R. Ziman
Pax Genes: Regulators Of Lineage Specification And Progenitor Cell Maintenance, Judith A. Blake, Mel R. Ziman
Research outputs 2014 to 2021
Pax genes encode a family of transcription factors that orchestrate complex processes of lineage determination in the developing embryo. Their key role is to specify and maintain progenitor cells through use of complex molecular mechanisms such as alternate RNA splice forms and gene activation or inhibition in conjunction with protein co-factors. The significance of Pax genes in development is highlighted by abnormalities that arise from the expression of mutant Pax genes. Here, we review the molecular functions of Pax genes during development and detail the regulatory mechanisms by which they specify and maintain progenitor cells across various tissue lineages. We …
A Quantitative Analysis Of The Mass Media Coverage Of Genomics Medicine In China: A Call For Science Journalism In The Developing World, Feifei Zhao, Yan Chen, Siqi Ge, Xinwei Yu, Shuang Shao, Michael Black, Youxin Wang, Jie Zhang, Manshu Song, Wei Wang
A Quantitative Analysis Of The Mass Media Coverage Of Genomics Medicine In China: A Call For Science Journalism In The Developing World, Feifei Zhao, Yan Chen, Siqi Ge, Xinwei Yu, Shuang Shao, Michael Black, Youxin Wang, Jie Zhang, Manshu Song, Wei Wang
Research outputs 2014 to 2021
Science journalism is a previously neglected but rapidly growing area of scholarship in postgenomics medicine and socio-technical studies of knowledge-based innovations. Science journalism can help evaluate the quantity and quality of information flux between traditional scientific expert communities and the broader public, for example, in personalized medicine education. Newspapers can play a crucial role in science and health communication, and more importantly, in framing public engagement. However, research on the role of newspaper coverage of genomics-related articles has not been readily available in resource-limited settings. As genomics is rapidly expanding worldwide, this gap in newspaper reportage in China is therefore …
Biomarkers Of Alzheimer's Disease Risk In Peripheral Tissues; Focus On Buccal Cells, Maxime François, Wayne Leifert, Ralph Martins, Philip Thomas, Michael Fenech
Biomarkers Of Alzheimer's Disease Risk In Peripheral Tissues; Focus On Buccal Cells, Maxime François, Wayne Leifert, Ralph Martins, Philip Thomas, Michael Fenech
Research outputs 2014 to 2021
Alzheimer's disease (AD) is a progressive degenerative disorder of the brain and is the most common form of dementia. To-date no simple, inexpensive and minimally invasive procedure is available to confirm with certainty the early diagnosis of AD prior to the manifestations of symptoms characteristic of the disease. Therefore, if population screening of individuals is to be performed, more suitable, easily accessible tissues would need to be used for a diagnostic test that would identify those who exhibit cellular pathology indicative of mild cognitive impairment (MCI) and AD risk so that they can be prioritized for primary prevention. This need …
Factors That Contribute To Balance And Mobility Impairments In Individuals With Huntington's Disease, Travis Cruickshank, Alvaro Reyes, Luis Peñailillo, Jennifer Thompson, Mel Ziman
Factors That Contribute To Balance And Mobility Impairments In Individuals With Huntington's Disease, Travis Cruickshank, Alvaro Reyes, Luis Peñailillo, Jennifer Thompson, Mel Ziman
Research outputs 2014 to 2021
Mobility and balance problems are common and often debilitating features of Huntington's disease (HD). In this exploratory study we aimed to investigate the influence of disease severity, severity of motor deficits, lower limb muscle strength, cognition, executive function, lean muscle mass and reactivity on mobility and balance.Twenty-two individuals with HD were recruited from the North Metropolitan Area Mental Health Service, Perth, Australia. Pertinent demographic, genetic and disease progression information was recorded prior to testing. Balance was assessed using dynamic and static balance tasks. Mobility was assessed using self-paced and fast-paced mobility measures. Cognitive and executive measures were used to assess …