Medicine and Health Sciences Commons^™

The Gut Microbiome Modulates Associations Between Adherence To A Mediterranean-Style Diet, Abdominal Adiposity, And C-Reactive Protein In Population-Level Analysis, Amy Jennings, Tilman Kühn, Nicola P. Bondonno, Sabina Waniek, Corinna Bang, Andre Franke, Jan Kassubek, Hans-Peter Müller, Marcus Both, Katharina S. Weber, Wolfgang Lieb, Aedín Cassidy

Research outputs 2022 to 2026

Background: Adherence to a Mediterranean-style dietary pattern is likely to have variable effects on body composition, but the impact of gut microbiome on this relationship is unknown. Objectives: To examine the potential mediating effect of the gut microbiome on the associations between Alternate Mediterranean Diet (aMed) scores, abdominal adiposity, and inflammation in population-level analysis. Design: In a community-based sample aged 25 to 83 y (n = 620; 41% female) from Northern Germany, we assessed the role of the gut microbiome, sequenced from 16S rRNA genes, on the associations between aMed scores, estimated using validated food-frequency questionnaires, magnetic resonance imaging-determined visceral …

Nutritional Strategies To Optimise Musculoskeletal Health For Fall And Fracture Prevention: Looking Beyond Calcium, Vitamin D And Protein, James Webster, Jack Dalla Via, Christina Langley, Cassandra Smith, Craig Sale, Marc Sim

Research outputs 2022 to 2026

Falls and osteoporotic fractures are a major public health problem, particularly among older adults. A third of individuals aged 65 years and over fall at least once each year, with up to 20 % of these resulting in serious injury, including fracture. In conjunction with regular exercise, the importance of diet for musculoskeletal health has largely focused upon calcium, vitamin D, and protein, particularly in the context of preventing falls and fractures. Whilst there is evidence for the benefits of these nutrients for musculoskeletal health, other aspects of the diet remain largely underexplored. For example, vegetables are rich sources of …

What Are The Most Effective Exercise, Physical Activity And Dietary Interventions To Improve Body Composition In Women Diagnosed With Or At High-Risk Of Breast Cancer? A Systematic Review And Network Meta-Analysis, Christine Kudiarasu, Pedro Lopez, Daniel A. Galvão, Robert U. Newton, Dennis R. Taaffe, Lorna Mansell, Brianna Fleay, Christobel Saunders, Caitlin Fox-Harding, Favil Singh

Research outputs 2022 to 2026

Background: Obesity has been recognized as a risk factor in the development and recurrence of breast cancer and is also associated with poor prognostic outcomes. This systematic review and network meta-analysis aimed to identify the most effective exercise, physical activity, and dietary interventions to reduce fat mass, body fat percentage and body weight as well as potentially increase lean mass in women diagnosed with or at high risk of breast cancer. Methods: A systematic search of databases was performed up to May 2022. Eligible randomized controlled trials examined the effects of exercise, physical activity and/or dietary interventions on fat mass …

Dietary And Supplemental Intake Of Vitamins C And E Is Associated With Altered Dna Methylation In An Epigenome-Wide Association Study Meta-Analysis, Amena Keshawarz, Roby Joehanes, Jiantao Ma, Gha Y. Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M. Masachs, Jordana T. Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimäki, Pashupati P. Mishra, Mika Kähönen, Olli Raitakari, Mika Helminen, Carol A. Wang, Phillip E. Melton, Rae-Chi Huang, Craig E. Pennell, Therese A. O’Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B.J. Van Meurs, Kristin L. Young, Misa Graff, Yujie Wang, Douglas P. Kiel, Caren E. Smith, Paul F. Jacques, Daniel Levy

Research outputs 2022 to 2026

BACKGROUND: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. METHODS: We meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association between self-reported dietary and supplemental intake of vitamins C and E with DNA methylation. EWAS were adjusted for age, sex, BMI, caloric intake, blood cell type proportion, smoking status, alcohol consumption, and technical covariates. Significant results of the meta-analysis were subsequently evaluated in gene set enrichment analysis (GSEA) and expression quantitative trait methylation (eQTM) analysis. RESULTS: …

Higher Overall Intakes Are The Defining Feature Of Dietary Intakes In Nafld And Compared To The General Population, Catherine Properzi, Leon A. Adams, Johnny Lo, Jill L. Sherriff, Gary P. Jeffrey, Therese A. O’Sullivan

Research outputs 2022 to 2026

We aimed to compare the dietary intakes of Australian patients with non-alcoholic fatty liver disease (NAFLD) to general Australian population intake data and determine whether the intake of any nutrient or food group was able to predict the degree of steatosis. Dietary data from fifty adult patients with NAFLD were compared to intake data from the Australian Health Survey for energy, macronutrients, fat sub-types, alcohol, iron, folate, sugar, fibre, sodium and caffeine. Linear regression models adjusting for potential confounders (age, sex, physical activity and body mass index) were used to examine predictive relationships between hepatic steatosis (quantified via magnetic resonance …

Association Of Healthful Plant-Based Diet Adherence With Risk Of Mortality And Major Chronic Diseases Among Adults In The Uk, Alysha S. Thompson, Anna Tresserra-Rimbau, Nena Karavasiloglou, Amy Jennings, Marie Cantwell, Claire Hill, Aurora Perez-Cornago, Nicola P. Bondonno, Neil Murphy, Sabine Rohrmann, Aedín Cassidy, Tilman Kühn

Research outputs 2022 to 2026

Importance: Plant-based diets have gained popularity for both environmental and health reasons, but a comprehensive assessment of their quality in relation to risk of mortality and major chronic diseases is lacking. Objective: To examine whether healthful vs unhealthful plant-based dietary patterns are associated with mortality and major chronic diseases among UK adults. Design, Setting, and Participants: This prospective cohort study used data from adults in the UK Biobank, a large-scale population-based study. Participants were recruited between 2006 and 2010 and followed up using record linkage data until 2021; follow-up for different outcomes ranged between 10.6 and 12.2 years. Data analysis …

Plant-Based Dietary Patterns And Parkinson's Disease: A Prospective Analysis Of The Uk Biobank, Anna Tresserra-Rimbau, Alysha S. Thompson, Nicola Bondonno, Amy Jennings, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Background: Plant-based diets have been associated with a lower risk of several chronic diseases, but the relationship with PD is unknown. Objectives: We examined the association of three different plant-based diets with PD incidence in the UK Biobank cohort. Methods: We conducted a prospective study among 126,283 participants from the UK Biobank cohort. Three plant-based diet indices (overall plant-based diet index, PDI; healthful plant-based diet index, hPDI; and unhealthful plant-based diet index, uPDI) were derived from 24-hour dietary recalls based on 17 food groups. Multivariable Cox regression models were used to estimate the risk of PD across quartiles of the …

Health Behaviour Profiles In Young Australian Adults In Relation To Physical And Mental Health: The Raine Study, Cecilie Thøgersen-Ntoumani, Daniel F. Gucciardi, Joanne A. Mcveigh, Therese A. O'Sullivan, Manon Dontje, Emmanuel Stamatakis, Peter R. Eastwood, Leon Straker

Research outputs 2022 to 2026

Issues Addressed: We aimed to identify latent health behaviour profiles of young adults and examine their associations with physical and mental health outcomes. We also characterised the profiles by socio-demographic characteristics. Methods: Data were collected between 2012 and 2014. Participants (N = 476) were young adults (M age [SD] = 22.1 [.57] years) from Generation 2 of the Raine Study longitudinal cohort. Health behaviours were measured via ActiGraph GT3X waist monitors (physical activity, sedentary behaviour) and questionnaires (diet quality, alcohol, smoking and sleep). Physical and mental health were measured using clinical health assessments, blood biomarkers, and questionnaires. Latent Profile Analysis …

Vitamin K-1 Intake And Incident Diabetes In The Danish Diet, Cancer, And Health Study, Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno

Research outputs 2022 to 2026

Context: Observational studies have reported lower risks of type 2 diabetes with higher vitamin K1 intake, but these studies overlook effect modification due to known diabetes risk factors. Objective: To identify subgroups that might benefit from vitamin K1 intake, we examined associations between vitamin K1 intake and incident diabetes overall and in subpopulations at risk of diabetes. Methods: Participants from the prospective cohort, the Danish Diet, Cancer, and Health Study, with no history of diabetes were followed up for diabetes incidence. The association between intake of vitamin K1, estimated from a food frequency questionnaire completed at baseline, and incident diabetes …

Development Of A Scoring Tool For Australian Rural Food Retail Environments, Tracy L. Schumacher, Carissa A. Alderton, Leanne J. Brown, Susan Heaney, Laura Alston, Katherine Kent, Stephanie L. Godrich

Research outputs 2022 to 2026

Current tools scoring the healthiness of food retail outlets do not reflect outlets found in rural locations. This study aimed to adapt pre-existing Australian scoring tools to represent non-metropolitan areas. Rural nutrition experts were identified, and a modified Delphi technique was used to adapt two pre-existing, food-scoring tools in five iterative stages. Stages included identifying all relevant outlets, providing a description and score for each, ensuring consistency between outlet scores and pre-existing, metro-centric tools, and providing instructions for correct use. Six rural nutrition experts were identified and engaged in the modified Delphi technique. The final tool consisted of 12 categories …

Vitamin K1 Intake And Incident Diabetes In The Danish Diet Cancer And Health Study: Supplemental Information, Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua Lewis, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schulz, Nicola P. Bondonno

Research outputs 2022 to 2026

No abstract provided.

Habitual Dietary Nitrate Intake And Cognition In The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing: A Prospective Cohort Study, Anjana Rajendra, Nicola P. Bondonno, Kevin Murray, Liezhou Zhong, Stephanie Rainey-Smith, Samantha Gardener, Lauren Blekkenhorst, David Ames, Paul Maruff, Ralph Martins, Jonathan M. Hodgson, Catherine P. Bondonno, Australian Imaging, Biomarkers And Lifestyle Group

Research outputs 2022 to 2026

Background & aims

Dietary nitrate improves cardiovascular health via a nitric oxide (NO) pathway. NO is key to both cardiovascular and brain health. There is also a strong association between vascular risk factors and brain health. Dietary nitrate intake could therefore be associated with better cognitive function and reduced risk of cognitive decline. This is yet to be investigated. The aim of this study was to investigate the association between habitual intake of dietary nitrate from sources where nitrate is naturally present, and cognitive function, and cognitive decline, in the presence or absence of the apolipoprotein E (APOE) …

A Comprehensive Examination Of The Evidence For Whole Of Diet Patterns In Parkinson's Disease: A Scoping Review, Joanna Rees, Jillian Ryan, Manja Laws, Amanda Devine

Research outputs 2022 to 2026

Both motor and non-motor symptoms of Parkinson’s disease (PD), a progressive neurological condition, have broad-ranging impacts on nutritional intake and dietary behaviour. Historically studies focused on individual dietary components, but evidence demonstrating ameliorative outcomes with whole-of-diet patterns such as Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is emerging. These diets provide plenty of antioxidant rich fruits, vegetables, nuts, wholegrains and healthy fats. Paradoxically, the ketogenic diet, high fat and very low carbohydrate, is also proving to be beneficial. Within the PD community, it is well advertised that nutritional intake is associated with disease progression and symptom severity but understandably, …

Resistant Starch As A Dietary Intervention To Limit The Progression Of Diabetic Kidney Disease, Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson

Research outputs 2022 to 2026

Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD through a number of pathways, including inflammation, oxidative stress, and the gut-kidney axis, which may be amenable to dietary therapy. Resistant starch (RS) is a dietary fibre that alters the gut microbial consortium, leading to an increase in the microbial production of short chain fatty acids. Evidence from animal and human studies indicate that short chain fatty acids are able to attenuate inflammatory …

Determinants Of Blood Acylcarnitine Concentrations In Healthy Individuals Of The European Prospective Investigation Into Cancer And Nutrition, Roland Wedekind, Joseph A. Rothwell, Vivian Viallon, Pekka Keski-Rahkonen, Julie A. Schmidt, Veronique Chajes, Vna Katzke, Theron Johnson, Maria Santucci De Magistris, Vittorio Krogh, Pilar Amiano, Carlotta Sacerdote, Daniel Redondo-Sánchez, José María Huerta, Anne Tjønneland, Pratik Pokharel, Paula Jakszyn, Rosario Tumino, Eva Ardanaz, Torkjel M. Sandanger, Anna Winkvist, Johan Hultdin, Matthias B. Schulze, Elisabete Weiderpass, Marc J. Gunter, Inge Huybrechts

Research outputs 2022 to 2026

Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty …

Effects Of A Multicomponent Resistance-Based Exercise Program With Protein, Vitamin D And Calcium Supplementation On Cognition In Men With Prostate Cancer Treated With Adt: Secondary Analysis Of A 12-Month Randomised Controlled Trial, Niamh Liana Mundell, Patrick J. Owen, Jack Dalla Via, Helen Macpherson, Robin Daly, Patricia M. Livingston, Timo Rantalainen, Stephen Foulkes, Jerremy Millar, Declan G. Murphy, Steve Fraser

Research outputs 2022 to 2026

OBJECTIVES: The aim of this preplanned secondary analysis of a 12-month randomised controlled trial was to investigate the effects of a multicomponent exercise programme combined with daily whey protein, calcium and vitamin D supplementation on cognition in men with prostate cancer treated with androgen deprivation therapy (ADT). DESIGN: 12-month, two-arm, randomised controlled trial. SETTING: University clinical exercise centre. PARTICIPANTS: 70 ADT-treated men were randomised to exercise-training plus supplementation (Ex+ Suppl, n=34) or usual care (control, n=36). INTERVENTION: Men allocated to Ex + Suppl undertook thrice weekly resistance training with weight-bearing exercise training plus daily whey protein (25 g), calcium (1200 …

Diet And Exercise Advice And Referrals For Cancer Survivors: An Integrative Review Of Medical And Nursing Perspectives, Ria Joseph, Nicolas H. Hart, Natalie Bradford, Oluwaseyifunmi Andi Agbejule, Bogda Koczwara, Alexandre Chan, Matthew P. Wallen, Raymond J. Chan

Research outputs 2022 to 2026

Purpose:

To examine the perspectives of medical and nursing health professionals concerning their roles and responsibilities in providing dietary and exercise advice to cancer survivors, and referrals to allied health professionals.

Methods:

An integrative review. PubMed, CINAHL, PsycINFO, Embase, Web of Science databases, and bibliographies of relevant studies were searched from December 2011 to June 2021. All studies were eligible for inclusion. The Mixed-Methods Appraisal Tool (MMAT) was used to critically appraise included studies. Data were extracted and synthesised regarding the perspectives of medical and nursing health professionals on their roles, responsibilities, barriers, and facilitators.

Results:

Twenty-one studies involving 3401 …

Precision Health In Behaviour Change Interventions: A Scoping Review, Chelsea E. Mauch, Sarah M. Edney, John Noel M. Viana, Shakuntla Gondalia, Hamza Sellak, Sarah J. Boud, Dakota D. Nixon, Jillian C. Ryan

Research outputs 2022 to 2026

Precision health seeks to optimise behavioural interventions by delivering personalised support to those in need, when and where they need it. Conceptualised a decade ago, progress toward this vision of personally relevant and effective population-wide interventions continues to evolve. This scoping review aimed to map the state of precision health behaviour change intervention research. This review included studies from a broader precision health review. Six databases were searched for studies published between January 2010 and June 2020, using the terms ‘precision health’ or its synonyms, and including an intervention targeting modifiable health behaviour(s) that was evaluated experimentally. Thirty-one studies were …

Mother's Own Milk Compared With Formula Milk For Feeding Preterm Or Low Birth Weight Infants: Systematic Review And Meta-Analysis, Natalie A. Strobel, Claire Adams, Daniel R. Mcaullay, Karen M. Edmond

Research outputs 2022 to 2026

Objectives: We assessed the effect of feeding preterm or low birth weight infants with infant formula compared with mother's own milk on mortality, morbidity, growth, neurodevelopment, and disability. Methods: We searched Medline (Ovid), Embase (Ovid), and Cochrane Central Register of Controlled Studies to October 1, 2021. Results: Forty-two studies enrolling 89 638 infants fulfilled the inclusion criteria. We did not find evidence of an effect on mortality (odds ratio [OR] 1.26, 95% confidence interval [CI] 0.91-1.76), infection (OR 1.52, 95% CI 0.98-2.37), cognitive neurodevelopment (standardized mean difference -1.30, 95% CI -3.53 to 0.93), or on growth parameters. Formula milk feeding …

Association Between Energy Balance-Related Factors And Clinical Outcomes In Patients With Ovarian Cancer: A Systematic Review And Meta-Analysis, Stephanie Stelten, Christelle Schofield, Yvonne A. W. Hartman, Pedro Lopez, Gemma G. Kenter, Robert U. Newton, Daniel A. Galvão, Meeke Hoedjes, Dennis R. Taaffe, Luc R. C. W. Van Lonkhuijzen, Carolyn Mcintyre, Laurien M. Buffart

Research outputs 2022 to 2026

Background:

This systematic review and meta-analysis synthesized evidence in patients with ovarian cancer at diagnosis and/or during first-line treatment on; (i) the association of body weight, body composition, diet, exercise, sedentary behavior, or physical fitness with clinical outcomes; and (ii) the effect of exercise and/or dietary interventions.

Methods:

Risk of bias assessments and best-evidence syntheses were completed. Meta-analyses were performed when ≥ 3 papers presented point estimates and variability measures of associations or effects.

Results:

Body mass index (BMI) at diagnosis was not significantly associated with survival. Although the following trends were not supported by the best-evidence syntheses, the meta-analyses …

Effects Of Dioscorea Polystachya 'Yam Gruel' On The Cognitive Function Of Diabetic Rats With Focal Cerebral Ischemia-Reperfusion Injury Via The Gut-Brain Axis, Shu Qin Pang, Zong Ting Luo, Carol Chunfeng Wang, Xue Pei Hong, Jian Zhou, Fang Chen, Li Ge, Xia Li, Yanling Dai, Yilan Wu, Jiahui Zhang

Research outputs 2014 to 2021

© 2020 Pang et al. Published by IMR press. Focal cerebral ischemia-reperfusion injury is closely related to hyperglycemia and gut microbiota imbalance, while gut microbiota contributes to the regulation of brain function through the gut-brain axis. Previous studies in patients with diabetes have found that 'yam gruel' is a classic medicated diet made from Dioscorea polystachya, increases the content of Bifidobacterium, regulates oxidative stress, and reduces fasting blood glucose levels. The research reported here investigated the effects of 'yam gruel' on the cognitive function of streptozotocin-induced diabetic rats with focal cerebral ischemia-reperfusion injury and explored the mechanism underlying the role …

Identifying Who Improves Or Maintains Their Food Literacy Behaviours After Completing An Adult Program, Andrea Begley, Ellen Paynter, Lucy Butcher

Research outputs 2014 to 2021

Food Sensations for Adults is a free four-week nutrition and cooking program that teaches low- to middle-income individuals food literacy. This research aimed to compare demographic characteristics of participants who completed the program’s follow-up questionnaire three months after program completion and assess whether food literacy and dietary behaviour changes were improved or maintained. Statistical analysis methods used factor scores of the plan and manage, selection, and preparation domains to examine mean self-reported changes in food literacy. Tertile stratification methods calculated changes in participants who had low, middle, and high end-of-program food literacy scores, and multivariable regression analysis explored the associations. …

Quantifying Dietary Vitamin K And Its Link To Cardiovascular Health: A Narrative Review, Claire R. Palmer, Lauren C. Blekkenhorst, Joshua R. Lewis, Natalie C. Ward, Carl J. Schultz, Jonathan M. Hodgson, Kevin D. Croft, Marc Sim

Research outputs 2014 to 2021

Cardiovascular disease is the leading cause of death and disability worldwide. Recent work suggests a link between vitamin K insufficiency and deficiency with vascular calcification, a marker of advanced atherosclerosis. Vitamin K refers to a group of fat-soluble vitamins important for blood coagulation, reducing inflammation, regulating blood calcium metabolism, as well as bone metabolism, all of which may play a role in promoting cardiovascular health. Presently, there is a lack of a comprehensive vitamin K database on individual foods, which are required to accurately calculate vitamin K1 and K2 intake for examination in epidemiological studies. This has likely contributed to …

Characterizing The Composition Of The Pediatric Gut Microbiome: A Systematic Review, Kane E. Deering, Amanda Devine, Therese A. O’Sullivan, Johnny Lo, Mary C. Boyce, Claus T. Christophersen

Research outputs 2014 to 2021

The consortium of trillions of microorganisms that live inside the human gut are integral to health. Little has been done to collate and characterize the microbiome of children. A systematic review was undertaken to address this gap (PROSPERO ID: CRD42018109599). MEDLINE and EMBASE were searched using the keywords: “healthy preadolescent children” and “gut microbiome” to 31 August 2018. Of the 815 journal articles, 42 met the inclusion criteria. The primary outcome was the relative abundance of bacteria at the phylum, family, and genus taxonomic ranks. α-diversity, short chain fatty acid concentrations, diet, 16S rRNA sequencing region, and geographical location were …

Summary Of Nutrition Among Aboriginal And Torres Strait Islander People, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

No abstract provided.

Implementation, Mechanisms Of Impact And Key Contextual Factors Involved In Outcomes Of The Modification Of Diet, Exercise And Lifestyle (Model) Randomised Controlled Trial In Australian Adults: Protocol For A Mixed-Method Process Evaluation, Reindolf Anokye, Simone Radavelli-Bagatini, Catherine P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Emma Connolly, Nicola P. Bondonno, John T. Schousboe, Richard Woodman, Kun Zhu, Pawel Zhu, Ben Jackson, James Dimmock, Markus P. Schlaich, Kay L. Cox, Douglas P. Kiel, Wai H. Lim, Amanda Devine, Peter L. Thompson, Jenny Gianoudis, Belinda De Ross, Robin M. Daly, Jonathan M. Hodgson, Joshua Lewis, Mandy Stanley

Research outputs 2014 to 2021

Introduction

The Modification of Diet, Exercise and Lifestyle (MODEL) study aims to examine the impact of providing visualisation and pictorial representation of advanced structural vascular disease (abdominal aortic calcification), on ‘healthful’ improvements to diet and lifestyle. This paper reports the protocol for the process evaluation for the MODEL study.

Methods and analysis

The overall aim of the process evaluation is to understand the processes that took place during participation in the MODEL study trial and which elements were effective or ineffective for influencing ‘healthful’ behavioural change, and possible ways of improvement to inform wider implementation strategies. A mixed-method approach will …

Modification Of Diet, Exercise And Lifestyle (Model) Study: A Randomised Controlled Trial Protocol, Simone Radavelli-Bagatini, Catherine P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Reindolf Anokye, Emma Connolly, Nicola P. Bondonno, John T. Schousboe, Richard J. Woodman, Kun Zhu, Pawel Szulc, Ben Jackson, James Dimmock, Markus P. Schlaich, Kay L. Cox, Douglas P. Kiel, Wai H. Lim, Mandy Stanley, Amanda Devine, Peter L. Thompson, Jenny Gianoudis, Belinda De Ross, Robin M. Daly, Joshua Lewis, Jonathan M. Hodgson

Research outputs 2014 to 2021

Introduction Most cardiovascular disease (CVD)-related events could be prevented or substantially delayed with improved diet and lifestyle. Providing information on structural vascular disease may improve CVD risk factor management, but its impact on lifestyle change remains unclear. This study aims to determine whether providing visualisation and pictorial representation of structural vascular disease (abdominal aortic calcification (AAC)) can result in healthful diet and lifestyle change.

Methods and analysis This study, including men and women aged 60–80 years, is a 12-week, two-arm, multisite randomised controlled trial. At baseline, all participants will have AAC assessed from a lateral spine image captured using a …

Validation And Reliability Of The Alzheimer’S Disease-Commonwealth Scientific And Industrial Research Organisation Food Frequency Questionnaire, Samantha L. Gardener, Philippa Lyons-Wall, Ralph Martins, Stephanie Rainey-Smith

Research outputs 2014 to 2021

Accuracy in measuring intake of dietary constituents is an important issue in studies reporting the associations between diet and chronic diseases. We modified a Commonwealth Scientific and Industrial Research Organisation (CSIRO) food frequency questionnaire (FFQ) to include foods of interest in the field of Alzheimer’s disease (AD) research. The aim of the current study was to determine the reliability and validity of the AD-CSIROFFQ in 148 cognitively normal older adults. The AD-CSIROFFQ was completed before and after completion of a four-day weighed food record. Of the 508 food and beverage items reported, 309 had sufficient consumption levels for analysis of …

Fruit And Vegetable Knowledge And Intake Within An Australian Population: The Ausdiab Study, Caroline R. Hill, Lauren C. Blekkenhorst, Simone Radavelli-Bagatini, Marc Sim, Richard J. Woodman, Amanda Devine, Jonathan E. Shaw, Jonathan M. Hodgson, Robin M. Daly, Joshua R. Lewis

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Understanding the relationship between fruit and vegetable knowledge (FVK) and fruit and vegetable intake (FVI) is an important consideration for improved public health and successful targeting of health promotion messaging. The aim of this study was to investigate the association between FVK and FVI in Australian adults and to identify subgroups most at risk of poor knowledge. Using data from the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab), we investigated associations between FVK and FVI, as well as demographic and lifestyle factors. Baseline FVK was measured using two self-reported questions. FVI …

Rehabilitation Strategies Following Oesophagogastric And Hepatopancreaticobiliary Cancer (Restore Ii): A Protocol For A Randomized Controlled Trial, Linda O'Neill, Emer Guinan, Suzanne Doyle, Deirdre Connolly, Jacintha O'Sullivan, Annemarie Bennett, Grainne Sheill, Ricardo Segurado, Peter Knapp, Ciaran Fairman, Charles Normand, Justin Geoghegan, Kevin Conlon, John V. Reynolds, Juliette Hussey

Research outputs 2014 to 2021

Background: Curative treatment for upper gastrointestinal (UGI) and hepatopancreaticobiliary (HPB) cancers, involves complex surgical resection often in combination with neoadjuvant/adjuvant chemo/chemoradiotherapy. With advancing survival rates, there is an emergent cohort of UGI and HPB cancer survivors with physical and nutritional deficits, resultant from both the cancer and its treatments. Therefore, rehabilitation to counteract these impairments is required to maximise health related quality of life (HRQOL) in survivorship. The initial feasibility of a multidisciplinary rehabilitation programme for UGI survivors was established in the Rehabilitation Strategies following Oesophago-gastric Cancer (ReStOre) feasibility study and pilot randomised controlled trial (RCT). ReStOre II will now …