Medicine and Health Sciences Commons^™

Integrating Diet And Exercise Into Care Of Prostate Cancer Patients On Androgen Deprivation Therapy, Mark A. Moyad, Robert Newton, Ulf W. Tunn, Damian Gruca

Research outputs 2014 to 2021

Improved diagnosis and treatment regimens have resulted in greater longevity for men with prostate cancer. This has led to an increase in both androgen deprivation therapy (ADT) use and duration of exposure, and therefore to its associated adverse effects, such as sexual dysfunction, osteoporosis, reduced muscle mass, increased fat mass, and increased incidence of cardiovascular disease and type 2 diabetes. Given that the adverse effects of ADT are systemic, often debilitating, and difficult to treat, efforts continue in the development of new strategies for long-term management of prostate cancer. The PubMed database was searched to select trials, reviews, and meta-analyses …

Prostate-Based Biofluids For The Detection Of Prostate Cancer: A Comparative Study Of The Diagnostic Performance Of Cell-Sourced Rna Biomarkers, Matthew J. Roberts, Renée S. Richards, Clement W. K. Chow, Suhail A. Doi, Horst J. Schirra, Marion A. Buck, Hemamali Samaratunga, Joanna L. Perry-Keene, Diane J. Payton, John W. Yaxley, Martin F. Lavin, Robert A. Gardiner

Research outputs 2014 to 2021

Background

Prostate cancer (PCa) diagnosis requires improvement with the aid of more accurate biomarkers. Postejaculate urethral washings (PEUW) could be a physiological equivalent to urine obtained following rectal prostatic massage, the current basis for the prostate cancer antigen 3 (PCA3) test. The aim of this study was to investigate if PEUW contained prostate-based material, evidenced by the presence of prostate specific antigen (PSA), and to evaluate the diagnostic performance of PEUW-based biomarkers.

Methods

Male patients referred for elevated serum PSA or abnormal digital rectal examination provided ejaculate and PEUW samples. PSA, PCA3, and β2-microglobulin (β2M) were quantified in ejaculate and …