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Full-Text Articles in Medicine and Health Sciences

The Potentials And Challenges Of Big Data In Public Health, Rena N. Vithiatharan Dec 2014

The Potentials And Challenges Of Big Data In Public Health, Rena N. Vithiatharan

Australian eHealth Informatics and Security Conference

The potential to use big data sources for public health increases with the broadening availability of data and improved methods of analysis. Whilst there are some well-known examples of the opportunistic use of big data, such as GoogleFlu, public health has not yet realised the full potential of such data sources. A literature review was undertaken to identify the potential of such data collections to impact public health, and to identify what challenges are currently limiting this potential. The potential include improved real-time analysis, research and development and genome studies. However, challenges listed are poor universal standardisation and classification, privacy …


Byod In Ehealth: Herding Cats And Stable Doors, Or A Catastrophe Waiting To Happen?, Krishnun Sansurooh, Patricia A H Williams Dec 2014

Byod In Ehealth: Herding Cats And Stable Doors, Or A Catastrophe Waiting To Happen?, Krishnun Sansurooh, Patricia A H Williams

Australian eHealth Informatics and Security Conference

The use of personal devices in the work environment has crossed the boundaries of work and socially related tasks. With cyber criminals seriously targeting healthcare for medical identity theft, the lack of control of new technologies within healthcare networks becomes an increasing vulnerability. The prolific adoption of personal mobile devices in the healthcare environment requires a proactive approach to the management of Bring Your Own Device (BYOD). This paper analysed the current state of the problem and the challenges that this creates in an environment that has stringent privacy and security requirements. The discourse demonstrates that the issue is not …


3rd Australian Ehealth Informatics And Security Conference, 2014, Edith Cowan University: Conference Details, Security Research Institute, Edith Cowan University Dec 2014

3rd Australian Ehealth Informatics And Security Conference, 2014, Edith Cowan University: Conference Details, Security Research Institute, Edith Cowan University

Australian eHealth Informatics and Security Conference

No abstract provided.


Customising Doctor-Nurse Communications, Brian Cusack, Dave Parry Dec 2014

Customising Doctor-Nurse Communications, Brian Cusack, Dave Parry

Australian eHealth Informatics and Security Conference

Doctor-Nurse communications are critical for patient safety and workflow effectiveness. Our research question was: What further improvements can be made to current communication systems? A variety of mobile and land based communication systems have been used and experimented with. In the study, the pager was found to be most common and more recent attempts to provide broadband capability with systems such as the iBeep. We built an alternative information system using Android phones and a software application that was customised by feedback from the medical professionals. The trial in five wards with 22 doctors and 170 nurses over one month …


Managing Wireless Security Risks In Medical Services, Brian Cusack, Akar Kyaw Dec 2014

Managing Wireless Security Risks In Medical Services, Brian Cusack, Akar Kyaw

Australian eHealth Informatics and Security Conference

Medical systems are designed for a range of end users from different professional skill groups and people who carry the devices in and on their bodies. Open, accurate, and efficient communication is the priority for medical systems and consequently strong protection costs are traded against the utility benefits for open systems. In this paper we assess the vulnerabilities created by the professional and end user expectations, and theorise ways to mitigate wireless security vulnerabilities. The benefits of wireless medical services are great in terms of efficiencies, mobility, and information management. These benefits may be realised by treating the vulnerabilities and …


Security Of Electronic Health Records In A Resource Limited Setting: The Case Of Smart-Care Electronic Health Record In Zambia, Keith Mweebo Dec 2014

Security Of Electronic Health Records In A Resource Limited Setting: The Case Of Smart-Care Electronic Health Record In Zambia, Keith Mweebo

Australian eHealth Informatics and Security Conference

This paper presents a case study of security issues related to the operationalization of smart-care, an electronic medical record (EMR) used to manage Human Immunodeficiency Virus (HIV) health information in Zambia. The aim of the smart-care program is to link up services and improve access to health information, by providing a reliable way to collect, store, retrieve and analyse health data in a secure way. As health professionals gain improved access to patient health information electronically, there is need to ensure this information is secured, and that patient privacy and confidentiality is maintained. During the initial stages of the program …


Avoiding Epic Fails: Software And Standards Directions To Increase Clinical Safety, Patricia A H Williams, Vincent B. Mccauley Dec 2014

Avoiding Epic Fails: Software And Standards Directions To Increase Clinical Safety, Patricia A H Williams, Vincent B. Mccauley

Australian eHealth Informatics and Security Conference

No abstract provided.


Big Data In Healthcare: What Is It Used For?, Rebecca Hermon, Patricia A H Williams Dec 2014

Big Data In Healthcare: What Is It Used For?, Rebecca Hermon, Patricia A H Williams

Australian eHealth Informatics and Security Conference

Big data analytics is a growth area with the potential to provide useful insight in healthcare. Whilst many dimensions of big data still present issues in its use and adoption, such as managing the volume, variety, velocity, veracity, and value, the accuracy, integrity, and semantic interpretation are of greater concern in clinical application. However, such challenges have not deterred the use and exploration of big data as an evidence source in healthcare. This drives the need to investigate healthcare information to control and reduce the burgeoning cost of healthcare, as well as to seek evidence to improve patient outcomes. Whilst …


Bite Marks On Skin And Clay: A Comparative Analysis, R K. Gorea, O. P. Jasuja, Abdulwahab Ali Abuderman, Abhinav Gorea Dec 2014

Bite Marks On Skin And Clay: A Comparative Analysis, R K. Gorea, O. P. Jasuja, Abdulwahab Ali Abuderman, Abhinav Gorea

Research outputs 2014 to 2021

Bite marks are always unique because teeth are distinctive. Bite marks are often observed at the crime scene in sexual and in physical assault cases on the skin of the victims and sometimes on edible leftovers in burglary cases. This piece of evidence is often ignored, but if properly harvested and investigated, bite marks may prove useful in apprehending and successfully prosecuting the criminals. Due to the importance of bite marks, we conducted a progressive randomised experimental study conducted on volunteers. A total of 188 bite marks on clay were studied. Based on these findings, 93.34% of the volunteers could …


Erratum To Traditional Chinese Medicine And New Concepts Of Predictive, Preventive And Personalised Medicine In Diagnosis And Treatment Of Sub-Optimal Health [The Epma Journal 5, (2014) 12], Wei Wang, Alyce Russell, Yuxiang Yan Aug 2014

Erratum To Traditional Chinese Medicine And New Concepts Of Predictive, Preventive And Personalised Medicine In Diagnosis And Treatment Of Sub-Optimal Health [The Epma Journal 5, (2014) 12], Wei Wang, Alyce Russell, Yuxiang Yan

Research outputs 2014 to 2021

No abstract provided.


Using Global Positioning Systems (Gps) And Temperature Data To Generate Time-Activity Classifications For Estimating Personal Exposure In Air Monitoring Studies: An Automated Method, Elizabeth Nethery, Gary Mallach, Daniel Rainham, Mark S. Goldberg, Amanda J. Wheeler May 2014

Using Global Positioning Systems (Gps) And Temperature Data To Generate Time-Activity Classifications For Estimating Personal Exposure In Air Monitoring Studies: An Automated Method, Elizabeth Nethery, Gary Mallach, Daniel Rainham, Mark S. Goldberg, Amanda J. Wheeler

Research outputs 2014 to 2021

Background: Personal exposure studies of air pollution generally use self-reported diaries to capture individuals’ time-activity data. Enhancements in the accuracy, size, memory and battery life of personal Global Positioning Systems (GPS) units have allowed for higher resolution tracking of study participants’ locations. Improved time activity classifications combined with personal continuous air pollution sampling can improve assessments of location-related air pollution exposures for health studies. Methods: Data was collected using a GPS and personal temperature from 54 children with asthma living in Montreal, Canada, who participated in a 10-day personal air pollution exposure study. A method was developed that …


Changes In Muscle Damage Markers In Female Basketball Players, A Moreira, Kazunori Nosaka, Ja Nunes, L Viveiros, A.Z. Jamurtas, M.S. Aoki Jan 2014

Changes In Muscle Damage Markers In Female Basketball Players, A Moreira, Kazunori Nosaka, Ja Nunes, L Viveiros, A.Z. Jamurtas, M.S. Aoki

Research outputs 2013

The aim of the present study was to investigate changes in muscle soreness, blood muscle damage markers, muscle strength and agility following an official basketball match. Eleven elite female professional basketball players (27.4 ± 4.8 years, 179.5 ± 5.5 cm, 72.0 ± 7.8 kg) of a team participated in this study. The official match was the seventh match of the season in the first phase of the Brazilian National Female Basketball Championship. Muscle soreness, plasma creatine kinase activity (CK), and myoglobin concentration (Mb) were determined before and after the match (post-match, 24 and 48 hours after the match). The 1RM …


Development Of A Medical Academic Degree System In China, Lijuan Wu, Youxin Wang, Xiaoxia Peng, Manshu Song, Xiuhua Guo, Hugh Nelson, Wei Wang Jan 2014

Development Of A Medical Academic Degree System In China, Lijuan Wu, Youxin Wang, Xiaoxia Peng, Manshu Song, Xiuhua Guo, Hugh Nelson, Wei Wang

Research outputs 2014 to 2021

Context: The Chinese government launched a comprehensive healthcare reform to tackle challenges to health equities. Medical education will become the key for successful healthcare reform. Purpose:We describe the current status of the Chinese medical degree system and its evolution over the last 80 years. Content: Progress has been uneven, historically punctuated most dramatically by the Cultural Revolution. There is a great regional disparity. Doctors with limited tertiary education may be licensed to practice, whereas medical graduates with advanced doctorates may have limited clinical skills. There are undefined relationships between competing tertiary training streams, the academic professional degree, and the clinical …


General Practitioners' Experiences Of Bereavement Care And Their Educational Support Needs: A Qualitative Study, Moira O'Connor, Lauren J. Breen Jan 2014

General Practitioners' Experiences Of Bereavement Care And Their Educational Support Needs: A Qualitative Study, Moira O'Connor, Lauren J. Breen

Research outputs 2014 to 2021

Background: General Practitioners (GPs) are well-positioned to provide grief support to patients. Most GPs view the provision of bereavement care as an important aspect of their role and the GP is the health professional that many people turn to when they need support. We aimed to explore GPs' understandings of bereavement care and their education and professional development needs in relation to bereavement care. Methods. An in-depth qualitative design was adopted using a social constructionist approach as our aims were exploratory and applied. Nineteen GPs (12 women and 7 men) living in Western Australia were interviewed; 14 were based in …


Contourlet Textual Features: Improving The Diagnosis Of Solitary Pulmonary Nodules In Two Dimensional Ct Images, Jingjing Wang, Tao Sun, Ni Gao, Desmond D. Menon, Yanxia Luo, Qi Gao, Xia Li, Wei Wang, Huiping Zhu, Pingxin Lv, Zhigang Liang, Lixin Tao, Xiangtong Liu, Xiuhua Guo Jan 2014

Contourlet Textual Features: Improving The Diagnosis Of Solitary Pulmonary Nodules In Two Dimensional Ct Images, Jingjing Wang, Tao Sun, Ni Gao, Desmond D. Menon, Yanxia Luo, Qi Gao, Xia Li, Wei Wang, Huiping Zhu, Pingxin Lv, Zhigang Liang, Lixin Tao, Xiangtong Liu, Xiuhua Guo

Research outputs 2014 to 2021

Materials and Methods: A total of 6,299 CT images were acquired from 336 patients, with 1,454 benign pulmonary nodule images from 84 patients (50 male, 34 female) and 4,845 malignant from 252 patients (150 male, 102 female). Further to this, nineteen patient information categories, which included seven demographic parameters and twelve morphological features, were also collected. A contourlet was used to extract fourteen types of textural features. These were then used to establish three support vector machine models. One comprised a database constructed of nineteen collected patient information categories, another included contourlet textural features and the third one contained both …


Pulmonary Function In Patients With Huntington's Disease, Alvaro Reyes, Travis Cruickshank, Mel Ziman, Ken Nosaka Jan 2014

Pulmonary Function In Patients With Huntington's Disease, Alvaro Reyes, Travis Cruickshank, Mel Ziman, Ken Nosaka

Research outputs 2014 to 2021

Background: Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric disturbances. Chest muscle rigidity, respiratory muscle weakness, difficulty in clearing airway secretions and swallowing abnormalities have been described in patients with neurodegenerative disorders including HD. However limited information is available regarding respiratory function in HD patients. The purpose of this study was to investigate pulmonary function of patients with HD in comparison to healthy volunteers, and its association with motor severity.Methods: Pulmonary function measures were taken from 18 (11 male, 7 female) manifest HD patients (53 ± 10 years), and 18 (10 male, 8 female) …


Hypoxia Alters Expression Of Zebrafish Microtubule-Associated Protein Tau (Mapta, Maptb) Gene Transcripts, Seyyed H. Moussavi Nik, Morgan Newman, Swamynathan Ganesan, Mengqi Chen, Ralph Martins, Giuseppe Verdile, Michael Lardelli Jan 2014

Hypoxia Alters Expression Of Zebrafish Microtubule-Associated Protein Tau (Mapta, Maptb) Gene Transcripts, Seyyed H. Moussavi Nik, Morgan Newman, Swamynathan Ganesan, Mengqi Chen, Ralph Martins, Giuseppe Verdile, Michael Lardelli

Research outputs 2014 to 2021

Background: Microtubule-associated protein tau (MAPT) is abundant in neurons and functions in assembly and stabilization of microtubules to maintain cytoskeletal structure. Human MAPT transcripts undergo alternative splicing to produce 3R and 4R isoforms normally present at approximately equal levels in the adult brain. Imbalance of the 3R-4R isoform ratio can affect microtubule binding and assembly and may promote tau hyperphosphorylation and neurofibrillary tangle formation as seen in neurodegenerative diseases such as frontotemporal dementia (FTD) and Alzheimer's disease (AD). Conditions involving hypoxia such as cerebral ischemia and stroke can promote similar tau pathology but whether hypoxic conditions cause changes in MAPT …


Psychophysiological Research Of Borderline Personality Disorder: Review And Implications For Biosocial Theory, Tara Cavazzi, Rodrigo Becerra Jan 2014

Psychophysiological Research Of Borderline Personality Disorder: Review And Implications For Biosocial Theory, Tara Cavazzi, Rodrigo Becerra

Research outputs 2014 to 2021

According to the Biosocial theory, Borderline Personality Disorder (BPD) is developed by a biological predisposition to hyperarousal and hyperreactivity combined with an invalidating environment. Although widely supported by subjective measures, the impaired insight present in BPD may skew results, and thus psychophysiological measures have been suggested as an alternative method of examining possible biological differences in BPD. The current review aimed to critically assess psychophysiological research of BPD by electronic searching of relevant databases, with 22 articles meeting inclusion criteria. Results showed that in contrast to the hyperarousal proposed in the Biosocial theory, BPD was associated with hypoarousal and hyporeactivity …


Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies, Prue Cormie, Suzanne K. Chambers, Robert U. Newton, Robert A. Gardiner, Nigel Spry, Dennis R. Taaffe, David Joseph, M Akhlil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A. Galvão Jan 2014

Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies, Prue Cormie, Suzanne K. Chambers, Robert U. Newton, Robert A. Gardiner, Nigel Spry, Dennis R. Taaffe, David Joseph, M Akhlil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A. Galvão

Research outputs 2014 to 2021

Background: Despite being a critical survivorship care issue, there is a clear gap in current knowledge of the optimal treatment of sexual dysfunction in men with prostate cancer. There is sound theoretical rationale and emerging evidence that exercise may be an innovative therapy to counteract sexual dysfunction in men with prostate cancer. Furthermore, despite the multidimensional aetiology of sexual dysfunction, there is a paucity of research investigating the efficacy of integrated treatment models. Therefore, the purpose of this study is to: 1) examine the efficacy of exercise as a therapy to aid in the management of sexual dysfunction in men …


Muscle Damage After A Tennis Match In Young Players, Rodrigo Vitasovic Gomes, Ricardo Santos, Ken Nosaka, Alexandre Moreira, Elen Miyabara, Marcelo Saldanha Aoki Jan 2014

Muscle Damage After A Tennis Match In Young Players, Rodrigo Vitasovic Gomes, Ricardo Santos, Ken Nosaka, Alexandre Moreira, Elen Miyabara, Marcelo Saldanha Aoki

Research outputs 2014 to 2021

The present study investigated changes in indirect markers of muscle damage following a simulated tennis match play using nationally ranked young (17.6 ± 1.4 years) male tennis players. Ten young athletes played a 3-hour simulated match play on outdoor red clay courts following the International Tennis Federation rules. Muscle soreness, plasma creatine kinase activity (CK), serum myoglobin concentration (Mb), one repetition maximum (1RM) squat strength, and squat jump (SJ) and counter movement jump (CMJ) heights were assessed before, immediately after, and 24 and 48 h after the simulated match play. All parameters were also evaluated in a non-exercised group (control …


Changes In Muscle Damage Markers In Female Basketball Players, Alexandre Moreira, Ken Nosaka, Joao Antonio Nunes, Luis Viveiros, Athanasios Z. Jamurtas, Marcelo Saldanha Aoki Jan 2014

Changes In Muscle Damage Markers In Female Basketball Players, Alexandre Moreira, Ken Nosaka, Joao Antonio Nunes, Luis Viveiros, Athanasios Z. Jamurtas, Marcelo Saldanha Aoki

Research outputs 2014 to 2021

The aim of the present study was to investigate changes in muscle soreness, blood muscle damage markers, muscle strength and agility following an official basketball match. Eleven elite female professional basketball players (27.4 ± 4.8 years, 179.5 ± 5.5 cm, 72.0 ± 7.8 kg) of a team participated in this study. The official match was the seventh match of the season in the first phase of the Brazilian National Female Basketball Championship. Muscle soreness, plasma creatine kinase activity (CK), and myoglobin concentration (Mb) were determined before and after the match (post-match, 24 and 48 hours after the match). The 1RM …


Reporting On The Seminar - Risk Interpretation And Action (Ria): Decision Making Under Conditions Of Uncertainty, Emma E. Doyle, Shabana Khan, Carolina Adler, Ryan C. Alaniz, Simone Athayde, Kuan H. Lin, Wendy Saunders, Todd Schenk, Fabiola Sosarodriguez, Victoria Sword-Daniels, Olayinka Akanle, Marie A. Baudoin, Chiung T. Chang, Karianne D. De Bruin, Riyanti Djalante, Christine Eriksen, Hsiang C. Lee, Jyoti Mishra, Victor O. Okorie, David R. Olanya, Goda Perlaviciute, Naxhelli Ruizrivera, Suzanne Vallance, Xinlu Xie, Lun Yin, Sarah Beaven, Charles Ebikeme, Richard Eiser, David Johnston, Christine Kenney, Douglas Paton, Sarah Schweizer, Vivi Stavrou Jan 2014

Reporting On The Seminar - Risk Interpretation And Action (Ria): Decision Making Under Conditions Of Uncertainty, Emma E. Doyle, Shabana Khan, Carolina Adler, Ryan C. Alaniz, Simone Athayde, Kuan H. Lin, Wendy Saunders, Todd Schenk, Fabiola Sosarodriguez, Victoria Sword-Daniels, Olayinka Akanle, Marie A. Baudoin, Chiung T. Chang, Karianne D. De Bruin, Riyanti Djalante, Christine Eriksen, Hsiang C. Lee, Jyoti Mishra, Victor O. Okorie, David R. Olanya, Goda Perlaviciute, Naxhelli Ruizrivera, Suzanne Vallance, Xinlu Xie, Lun Yin, Sarah Beaven, Charles Ebikeme, Richard Eiser, David Johnston, Christine Kenney, Douglas Paton, Sarah Schweizer, Vivi Stavrou

Research outputs 2014 to 2021

The paper reports on the World Social Science (WSS) Fellows seminar on Risk Interpretation and Action (RIA), undertaken in New Zealand in December, 2013. This seminar was coordinated by the WSS Fellows program of the International Social Science Council (ISSC), the RIA working group of the Integrated Research on Disaster Risk (IRDR) program, the IRDR International Center of Excellence Taipei, the International START Secretariat and the Royal Society of New Zealand. Twenty-five early career researchers from around the world were selected to review the RIA framework under the theme of 'decision-making under conditions of uncertainty', and develop novel theoretical approaches …


A Comparison Of Aphasia Therapy Outcomes Before And After A Very Early Rehabilitation Programme Following Stroke, Erin Godecke, Natalie A. Ciccone, Andrew S. Granger, Tapan Rai, Deborah West, Angela Cream, Jade Cartwright, Graeme J. Hankey Jan 2014

A Comparison Of Aphasia Therapy Outcomes Before And After A Very Early Rehabilitation Programme Following Stroke, Erin Godecke, Natalie A. Ciccone, Andrew S. Granger, Tapan Rai, Deborah West, Angela Cream, Jade Cartwright, Graeme J. Hankey

Research outputs 2014 to 2021

Background Very early aphasia rehabilitation studies have shown mixed results. Differences in therapy intensity and therapy type contribute significantly to the equivocal results. Aims To compare a standardized, prescribed very early aphasia therapy regimen with a historical usual care control group at therapy completion (4-5 weeks post-stroke) and again at follow-up (6 months). Methods & Procedures This study compared two cohorts from successive studies conducted in four Australian acute/sub-acute hospitals. The studies had near identical recruitment, blinded assessment and data-collection protocols. The Very Early Rehabilitation (VER) cohort (N = 20) had mild-severe aphasia and received up to 20 1-h sessions …


Pgc-1Α Mediated Muscle Aerobic Adaptations To Exercise, Heat And Cold Exposure, Mohammed Ihsan, Greig Watson, Chris R. Abbiss Jan 2014

Pgc-1Α Mediated Muscle Aerobic Adaptations To Exercise, Heat And Cold Exposure, Mohammed Ihsan, Greig Watson, Chris R. Abbiss

Research outputs 2014 to 2021

PGC-1α is regarded as a key regulator of mitochondrial biogenesis due to its central role in regulating the activity of key transcription factors associated with encoding mitochondrial components. Additionally, PGC-1α has shown to mediate adaptations that increase fat metabolism and angiogenesis, contributing to the overall oxidative phenotype of the muscle. While it is well established that exercise is a potent stimulator of PGC-1α, recent evidence indicates that heat and cold exposures may also influence mitochondrial biogenesis through the up-regulation of PGC-1α. This highlights the potential use of these modalities in conjunction with exercise to enhance training adaptations. As such, the …


Links Between Insulin Resistance, Lipoprotein Metabolism And Amyloidosis In Alzheimer's Disease, Ian J. Martins, Rhona Creegan Jan 2014

Links Between Insulin Resistance, Lipoprotein Metabolism And Amyloidosis In Alzheimer's Disease, Ian J. Martins, Rhona Creegan

Research outputs 2014 to 2021

The origins of premature brain aging and chronic disease progression are associated with atherogenic diets and sedentary lifestyles in Western communities. Interests in brain aging that involves non alcoholic fatty liver disease (NAFLD), the global stroke epidemic and neurodegeneration have become the focus of nutritional research. Atherogenic diets have been linked to plasma ceramide dysregulation and insulin resistance actively promoting chronic diseases and neurodegeneration in developed countries. Abnormal lipid signaling as observed in chronic diseases such as hypothyroidism, obesity and diabetes is connected to stroke and neurodegenerative diseases in man. Lipids that are involved in calcium and amyloid betahomeostasis are …


Social Engagement, Setting And Alcohol Use Among A Sample Of Older Australians, Julie Dare, Celia Wilkinson, Steve Allsop, Stacey Waters, Sheila Mchale Jan 2014

Social Engagement, Setting And Alcohol Use Among A Sample Of Older Australians, Julie Dare, Celia Wilkinson, Steve Allsop, Stacey Waters, Sheila Mchale

Research outputs 2014 to 2021

The harms associated with risky alcohol consumption have long been researched and recognised in the health field. However, little available research has focused on older people, or extended analysis of alcohol use by this segment of the population beyond a bio-medical perspective. With the rapid ageing of the global population, research that investigates alcohol use amongst older people from a social perspective is important. This article reports on research with a group of older women and men, to identify and explain factors that influence alcohol consumption. In-depth interviews were conducted in Perth, Western Australia with 20 men and 22 women …


Pax Genes: Regulators Of Lineage Specification And Progenitor Cell Maintenance, Judith A. Blake, Mel R. Ziman Jan 2014

Pax Genes: Regulators Of Lineage Specification And Progenitor Cell Maintenance, Judith A. Blake, Mel R. Ziman

Research outputs 2014 to 2021

Pax genes encode a family of transcription factors that orchestrate complex processes of lineage determination in the developing embryo. Their key role is to specify and maintain progenitor cells through use of complex molecular mechanisms such as alternate RNA splice forms and gene activation or inhibition in conjunction with protein co-factors. The significance of Pax genes in development is highlighted by abnormalities that arise from the expression of mutant Pax genes. Here, we review the molecular functions of Pax genes during development and detail the regulatory mechanisms by which they specify and maintain progenitor cells across various tissue lineages. We …


Factors Influencing Pacing In Triathlon, Sam Shi Xuan Wu, Jeremiah P. Peiffer, Jeanick Brisswalter, Kazunori Nosaka, Chris Abbiss Jan 2014

Factors Influencing Pacing In Triathlon, Sam Shi Xuan Wu, Jeremiah P. Peiffer, Jeanick Brisswalter, Kazunori Nosaka, Chris Abbiss

Research outputs 2014 to 2021

Triathlon is a multisport event consisting of sequential swim, cycle, and run disciplines performed over a variety of distances. This complex and unique sport requires athletes to appropriately distribute their speed or energy expenditure (ie, pacing) within each discipline as well as over the entire event. As with most physical activity, the regulation of pacing in triathlon may be influenced by a multitude of intrinsic and extrinsic factors. The majority of current research focuses mainly on the Olympic distance, whilst much less literature is available on other triathlon distances such as the sprint, half-Ironman, and Ironman distances. Furthermore, little is …


Selection Of An Instrument To Evaluate The Organizational Environment Of Nurses Working In Intensive Care: An Integrative Review, Brett Abbenbroek, Christine M. Duffield, Doug Elliot Jan 2014

Selection Of An Instrument To Evaluate The Organizational Environment Of Nurses Working In Intensive Care: An Integrative Review, Brett Abbenbroek, Christine M. Duffield, Doug Elliot

Research outputs 2014 to 2021

To determine an appropriate survey instrument to evaluate the impact of organizational structures on the work environment of intensive care nurses.


Traditional Chinese Medicine And New Concepts Of Predictive, Preventive And Personalized Medicine In Diagnosis And Treatment Of Suboptimal Health, Wei Wang, Alyce C. Russell, Yuxiang Yan Jan 2014

Traditional Chinese Medicine And New Concepts Of Predictive, Preventive And Personalized Medicine In Diagnosis And Treatment Of Suboptimal Health, Wei Wang, Alyce C. Russell, Yuxiang Yan

Research outputs 2014 to 2021

The premise of disease-related phenotypes is the definition of the counterpart normality in medical sciences. Contrary to clinical practices that can be carefully planned according to clinical needs, heterogeneity and uncontrollability is the essence of humans in carrying out health studies. Full characterization of consistent phenotypes that define the general population is the basis to individual difference normalization in personalized medicine. Self-claimed normal status may not represent health because asymptomatic subjects may carry chronic diseases at their early stage, such as cancer, diabetes mellitus and atherosclerosis. Currently, treatments for non-communicable chronic diseases (NCD) are implemented after disease onset, which is …