Medicine and Health Sciences Commons^™

Rat Dendritic Cells Function As Accessory Cells And Control The Production Of A Soluble Factor Required For Mitogenic Responses Of T Lymphocytes., Wolfgang E. Klinkert, Jon H. Labadie, James P. O'Brien, Carl F. Beyer, William E. Bowers

Dartmouth Scholarship

Transformation of T lymphocytes, induced by treatment with periodate or with neuraminidase plus galactose oxidase, requires the participation of accessory cells. Procedures were developed for the fractionation of rat lymph node cells, by which most of the lymphocytes can be recovered as a major population of cells that do not respond to mitogenic stimulation unless accessory cells from a separated minor population are added. Further purification led to a 1000-fold overall increase in accessory activity per cell, with a 50-70% yield. The purest preparations were virtually free of macrophages and contained more than 90% typical dendritic cells. Maximum responses occurred …

A Small Area Approach To The Analysis Of Health Systems Performance, John E. Wennberg, Alan Gittelsohn

Dartmouth Scholarship

Methods and techniques for acquiring and analyzing data have been an area of primary concern for State and local health planning agencies since their initial designation. As their responsibilities have developed and the factors become more complex, the agencies have realized an even greater need for analytic processes for evaluating the performance of their health care systems and determining future directions of their programs.

Cellular Action Of Vasopressin In Medullary Tubules Of Mice With Hereditary Nephrogenic Diabetes Insipidus, Brian A. Jackson, Richard M. Edwards, Heinz Valtin, Thomas P. Dousa

Dartmouth Scholarship

Our previous studies (1974. J. Clin. Invest.54: 753-762.) suggested that impaired metabolism of cyclic AMP (cAMP) may be involved in the renal unresponsiveness to vasopressin (VP) in mice with hereditary nephrogenic diabetes insipidus (NDI). To localize such a defect to specific segments of the nephron, we studied the activities of VP-sensitive adenylate cyclase, cAMP phosphodiesterase (cAMP-PDIE), as well as accumulation of cAMP in medullary collecting tubules (MCT) and in medullary thick ascending limbs of Henle's loop (MAL) microdissected from control mice with normal concentrating ability and from mice with hereditary NDI.

Adenylate cyclase activity stimulated by VP or by …

China's Revolution In Health, Norman Miller, James C. Strickler

Dartmouth Scholarship

China today is in the midst of a peaceful revolution that is dramatically changing the very nature of that vast country. Since the death of Chairman Mao and the political demise of the *Gang of Four," there has occurred a major re-emphasis on change and Western technology. To achieve their political goals the new regime, under Chairman Hua Kwo-Fenj, has emphasized "four modernizations": science, industry, national defense, and agriculture. Health and medicine are seen as a part of the scientific arena. The planned changes in this sector will plunge China into a Western form of technology that will certainly have …