Medicine and Health Sciences Commons^™

Development Of Novel Zika And Anthrax Viral Nanoparticle Vaccines, Elizabeth Henderson

KGI Theses and Dissertations

Vaccines protect against numerous infectious diseases and prevent millions of deaths annually, but there are still many infectious diseases for which no licensed vaccine exists. Developing a new vaccine requires balancing safety and efficacy, and viral nanoparticle (VNP) vaccines possess both of these characteristics. The work herein demonstrates how tobacco mosaic virus (TMV) nanoparticles can serve as a platform to create candidate vaccines for Zika virus (ZIKV) and anthrax. In the first study, a ZIKV-specific epitope was genetically fused to TMV to create a safe and inexpensive vaccine that proved highly immunogenic in mice and led to the discovery of …

Mathematical Modeling Of Type 1 Diabetes, Gianna Wu

HMC Senior Theses

Type 1 Diabetes (T1D) is an autoimmune disease where the pancreas produces little to no insulin, which is a hormone that regulates blood glucose levels. This happens because the immune system attacks (and kills) the beta cells of the pancreas, which are responsible for insulin production. Higher levels of glucose in the blood could have very negative, long term effects such as organ damage and blindness.

To date, T1D does not have a defined cause nor cure, and research for this disease is slow and difficult due to the invasive nature of T1D experimentation. Mathematical modeling provides an alternative approach …

Attribution Theory And Increasing Social Support For Women With Postpartum Depression: An Exploration Of Perceived Stability, Onset Controllability, And Effort, Andrea L. Ruybal

CGU Theses & Dissertations

Women with postpartum depression (PPD) deal with the negative impact of depression, as well as the burden of stigma (i.e., negative stereotypes). Guided by the attribution-emotion-action model (Weiner, 1980a), the current studies seek to assess whether emphasizing the temporary nature of PPD (i.e., stability), the uncontrollable development of the ailment (i.e., onset controllability), and whether it appears someone is making an effort to overcome PPD will indirectly result in greater social support, through anger, sympathy, and social support outcome expectations. This approach, utilizing combinations of three different attributions, along with social support outcome expectations as a mediator has not been …

The Intergenerational Transfer Of Criminal Justice Involvement: Risk And Protective Factors As Moderating Variables, Caitlin Storm

CGU Theses & Dissertations

Previous literature identified evidence of a transfer of criminal justice involvement between generations of family members. This relationship has proven especially strong between parents and children. Different demographic factors slightly alter the strength and significance of the transfer, but the established relationship between the criminal justice involvement of the parent and the increased likelihood of the child’s criminal justice involvement remains consistent. Data from the National Longitudinal Survey of Youth 1997 was used to analyze the effect of the father’s criminal justice involvement on his child’s. Using binary logistic regression models, predictor variables were included in a step-wise fashion to …

Identification Of Antibiotic Ge37468a From Pseudonocardia Symbionts Of Trachymyrmex Septentrionalis Ants, Krithika Rao

Scripps Senior Theses

In response to the growing rates of antibiotic resistance in human bacterial pathogens, this study explores the natural products involved in the defensive symbiosis between actinobacteria and fungus-growing ants to uncover new potential antibiotics. This study also seeks to understand the function of natural antibiotics in their ecological contexts, especially those involved in defensive symbioses. Defensive symbiosis can be a beneficial platform for discovering useful antibiotics, because antibiotics in these relationships must be able to selectively inhibit enemies without harming hosts, and are therefore likely more specific and less toxic. Pseudonocardia sp. associated with Trachymyrmex septentrionalis ants demonstrated antibiotic activity …

Louis De La Forge On Mind-Body Interaction And The Case Against Occasionalism, Melissa Kalaee Gholamnejad

CGU Theses & Dissertations

Fidelity to the Cartesian philosophy requires a defense of dualism as well as mind-body union and interaction, all the while keeping to some form of the causal likeness principle. Each of these positions are ones that Descartes maintained throughout his writings. Yet, successors and scholars alike have noted the inconsistencies that arise from defending these views conjointly and have argued that one or more of them should be abandoned. Even the first generation of Cartesian successors whose fidelity to the Cartesian principles was especially steadfast, such as Louis de la Forge, have been interpreted and characterized as giving up causal …

The Role Of Serum Histones In Canine Heat Stroke, Jenna Acutt

Scripps Senior Theses

Rising temperatures all over the world has correlated with more frequent heat stroke related injuries and death. This statistic not only applies to humans, but to canines as well, who have similar body temperature thresholds. Recent studies have demonstrated that serum histones, released after cell death from heat stroke, play a role in heat stroke related injuries and death. This proposal aims to determine the severity of the effects caused by serum histone release after heat stroke by exposing selected canine cell lines to cell lysate and purified histones H2A, H2B, H3, and H4, which have been found to be …

Implicit Attitudes Of Asian American Older Adults Toward Aging, Anita Ho

Scripps Senior Theses

Greenwald, McGhee, and Schwartz (1998) developed the Implicit Association Test (IAT), a measure of mental associations between target pairs and positive or negative attributes. Highly associative categories yield faster responses than the reverse mental associations, which is thought to reflect implicit attitudes toward stereotypes. The present study investigated the effect of ethnic group on one’s implicit attitudes toward aging and gender stereotypes by comparing two groups of older adults, Asian Americans and Caucasian Americans, that likely hold different culture values. Past qualitative studies have established the existence of mental health stigma in Asian American populations, including negative Asian American perceptions …

Relations Among Maternal And Paternal Behavior And Children's Stress Biology, S.K. Jiaming Lin, Stacey N. Doan, John Milton

Scripps Senior Theses

Parenting behavior has been shown to have a wide range of effects, influencing children’s psychological and biological stress outcomes. Most research focuses on maternal parenting behaviors, with few studies observing the effects of paternal behaviors or the influence of both parents on their children. In this study, the relationship between maternal and paternal parenting behaviors was examined in its association to predict children’s cortisol levels. Cultural differences in parenting styles was also observed. American (N=86) and Chinese (N=97) families participated in the study, with parents reporting their behaviors. Children’s cortisol was collected during a stressor task and correlational analysis was …

Investigating Neurogenesis As A Veritable Epigenetic Endophenotype For Alzheimer's Disease, Layne Wells

Scripps Senior Theses

Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by progressive amyloid plaque aggregation, neurofibrillary tangles, and cortical tissue death. As the prevalence of AD is projected to climb in coming years, there is a vested interest in identifying endophenotypes by which to improve diagnostics and direct clinical interventions. The risk for complex disorders, such as AD, is influenced by multiple genetic, environmental, and lifestyle factors. Significant strides have been made in identifying genetic variants linked to AD through the genome-wide association study (GWAS). It has been estimated in more recent years, however, that GWAS-identified variants account for limited …

Racial Disparities In The Diagnosis And Treatment Of Type 1 Diabetes In Black American Youth, Kierra Mitchell

Scripps Senior Theses

Introduction: Rates of childhood-onset type 1 diabetes (T1D) are steadily increasing among American youth, yet Black Americans are more likely to suffer from serious T1D-related complications caused by poor glycemic control. The aim of this thesis is to determine the external factors that are causing discrepancies in the development, diagnosis, treatment, and long-term management of T1D in Black youth.

Methods: Epidemiological studies were compiled from the American Diabetes Association, Center for Disease Control (CDC), International Diabetes Foundation (IDF), Kaiser Family Foundation (KFF), and the Claremont Colleges Library network to identify the sociocultural aspects that negatively affect long-term glycemic control in …

Detection Of Sickle Cell Disease-Associated Single Nucleotide Polymorphism Using A Graphene Field Effect Transistor, Kandace Fung

CMC Senior Theses

Sickle Cell Disease (SCD) is a hereditary monogenic disorder that affects millions of people worldwide and is associated with symptoms such as stroke, lethargy, chronic anemia, and increased mortality. SCD can be quickly detected and diagnosed using a simple blood test as an infant, but as of now, there is currently limited treatment to cure an individual of sickle cell disease. Recently, there have been several promising developments in CRISPR-Cas-associated gene-editing therapeutics; however, there have been limitations in gene-editing efficiency monitoring, which if improved, could be beneficial to advancing CRISPR-based therapy, especially in SCD. The CRISPR-Chip, a three-terminal graphene-based field …

Giardia Lamblia Growth In Viscoelastic Fluids, Kelly Watanabe

CMC Senior Theses

Giardia lamblia is a single-celled protozoan parasite that when ingested, causes diarrheal disease and infects 33% of people in developing countries. Previous studies observe Giardia in water-like fluids, but Giardia's infectious environment consists of viscoelastic mucus in the small intestine. Therefore, Giardia was cultured in viscoelastic fluids, and its population growth was observed in vitro. To create shear-thinning viscoelastic fluids, 0.2% and 0.4% long-chain polyacrylamide (LCPAM) was added to cell culture media. Giardia was cultured in control media, 0.2% LCPAM, and 0.4% LCPAM, and population growth was quantitatively determined over time. Increasing LCPAM concentration resulted in a solution with …

Healthy Skepticism: The Relationship Between Funding Source And Conclusion In Nutrition-Related Scientific Articles On Saturated Fat, Lili Muskal

CMC Senior Theses

Recently published scientific articles have led to mixed nutritional advice on dietary saturated fatty acids. Lesser et. al (2007) identified that mixed conclusions in scientific articles on sweetened beverages might be attributed industry funding, as articles funded by the beverage industry are four to eight times more likely to report conclusions in favor of the sponsor’s products. This thesis applies Lesser’s methods to determine whether industry funding influences the inconsistent conclusions on saturated fatty acids. This thesis analyzes 100 articles on foods high in dietary saturated fatty acids. While studies with food industry funding are more likely to produce favorable …

Fostering Transformational Leadership In Asian Americans: How To Reach The C-Suite, Khadija Ganijee

CMC Senior Theses

This paper investigates what has caused a lack of Asian American leadership in the corporate space and how transformational leadership can be the solution for these people by using their culture to their advantage. This was accomplished through a comprehensive review of transformational leadership and the personality traits associated with it, as well as psychological research on Asian American issues in the workplace and the role of Asian American culture. Stereotyping and discrimination play a role in the workplace, but usually, what a person can do to combat these issues is not explicated. This thesis aims to fill in that …

An Analysis And Critique Of Mental Health Treatment In American State Prisons And Proposal For Improved Care, Shelby Hayne

Scripps Senior Theses

Mental health treatment in state prisons is revealed to be highly variable, under-funded, and systematically inadequate. Existing literature exposes this injustice but fails to provide a comprehensive proposal for reform. This paper attempts to fill that gap, outlining a cost-effective, evidence-based treatment proposal, directly addressing the deficits in care revealed through analysis of our current system. In addition, this paper provides historical overviews of the prison system and mental health treatment, utilizing theoretical perspectives to contextualize this proposal in the present state of affairs. Lastly, the evidence is provided to emphasize the potential economic and social benefits of improving mental …

Integrating Alexander Technique Into Treatment Of Adolescent Idiopathic Scoliosis To Improve Patient Quality Of Life, Ana Nishioka

Scripps Senior Theses

The following thesis posits training in the Alexander Technique as a possible solution to address the comorbidities of poor body image and reduced feelings of efficacy in patients treated for adolescent idiopathic scoliosis (AIS). Both literature and personal accounts of AIS highlight that current conservative methods of treating AIS offered by the Western medical sphere, including observation, bracing, and physical therapy, do not adequately address, and may actually exacerbate, negative mental health symptoms. Patients are often represented as their external orthopedic diagnosis and receive limited emotional guidance in exploring their internal feelings about their body and its capabilities. Alexander Technique …

Ecological Influences On Dietary Behavior: The Interaction Between Person And Neighborhood Environment In A Low-Ses, Hispanic Community, Emily Kiresich

CGU Theses & Dissertations

Despite existing knowledge about lifestyle choices and their relationships to obesity and diabetes, the prevalence of Type 2 Diabetes Mellitus (T2DM) is increasing, and the number of Americans at risk is greater than 70% (CDC, 2019). Obesity is a complex, multifactorial, and largely preventable disease, affecting, along with overweight, over a third of the world's population today. A significant factor in lifestyle management is the ecology of food choice. Literature suggests that environment and exposure can predict food-related health risk behaviors and health outcomes. The objective of this dissertation was to conceptualize and carry out a series of pilot studies …

Dil - A Conversational Agent For Heart Failure Patients, Sanjoy Moulik

CGU Theses & Dissertations

There is an exceptionally high rate of readmissions and rehospitalizations for patients suffering from chronic diseases especially Heart Failure. Best efforts to address this alarming problem from the Care giver community have fallen short due to a number of factors most notably resource constraints like shortage of trained clinical staff, and money. Using a Design Science Research framework, this work designed and evaluated "DIL", a Conversational Agent that complements the work of clinicians in achieving the desired behavioral and clinical outcomes. The aim is to provide the hospital with an information system that could bridge the current gap in care …

A Systematic Review Of Medical Students’ And Professionals’ Attitudes And Knowledge Regarding Medical Cannabis As A Proxy For Forecasting Trends In The Medical Community’S Acceptance Of Therapeutic Hallucinogens, Jared Weisman

Pitzer Senior Theses

Background: In recent years, the renewed global interest in both hallucinogens’ and cannabis’ therapeutic properties has resulted in shifting attitudes and legislative policies worldwide. The aim of this systematic review is to explore the existing literature on medical professionals’ and students’ attitudes and knowledge regarding medicinal cannabis (MC) to assess any relevant and significant trends which may forecast analogous trends in the nascent clinical acceptance of hallucinogens.

Methods: Using Google Scholar and PubMed, a literature search was performed to identify studies pertaining to healthcare professionals’ and medical students’ knowledge and attitudes regarding MC. This systematic search yielded 43 studies published …

Put Your Money Where Your Mouth Is: Reforming Organized Dentistry To Address Persistent Oral Health Disparities In The U.S., Aparna Chintapalli

Pomona Senior Theses

The importance of oral health has been largely neglected from the conventional standards of healthcare in terms of public understanding & prioritization, the industrial infrastructure, and the scope of prevention & early-intervention services. Its adjunctive locus to the field of medicine has lead to the bifurcation of the oral cavity from the rest of the human body. As a result of this divide, there have been multiple factors that have allowed socially stratified oral health outcomes to manifest. This thesis examines the determinants of oral health disparities through a multidisciplinary lens (i.e. biology, public policy, infrastructure), and offers evidence of …