Open Access. Powered by Scholars. Published by Universities.®
Johns Hopkins University, Dept. of Biostatistics Working Papers
Blood-brain barrier; Multiple sclerosis; MRI; DCE-MRI; Gadolinium enhancement; Functional principal components analysis
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Population-Wide Model-Free Quantification Of Blood-Brain-Barrier Dynamics In Multiple Sclerosis, Russell T. Shinohara, Ciprian Crainiceanu, Brian Caffo, María Inés Gaitán, Daniel Reich
Population-Wide Model-Free Quantification Of Blood-Brain-Barrier Dynamics In Multiple Sclerosis, Russell T. Shinohara, Ciprian Crainiceanu, Brian Caffo, María Inés Gaitán, Daniel Reich
Johns Hopkins University, Dept. of Biostatistics Working Papers
The processes by which new white matter lesions in multiple sclerosis (MS) develop are only partially understood. Much of this understanding has come through magnetic resonance imaging (MRI) of the human brain. One of the hallmarks of new lesion development in MS is enhancement on T1-weighted MRI scans following the intravenous administration of a gadolinium-based contrast agent that shortens the longitudinal relaxation time of the tissue. This visible enhancement in the MRI results from the opening of the blood-brain barrier and reveals areas of active inflammation. The incidence and number of existing enhancing lesions are common outcome measures used in …