Medicine and Health Sciences Commons^™

Opposing Immune-Metabolic Signature In Visceral Versus Subcutaneous Adipose Tissue In Patients With Adenocarcinoma Of The Oesophagus And The Oesophagogastric Junction, Aisling B. Heeran, Jessica Mccready, Margaret R. Dunne, Noel E. Donlon, Timothy S. Nugent, Anshul Bhardwaj, Kathleen A. J. Mitchelson, Amy M. Buckley, Narayanasamy Ravi, Helen M. Roche, John V. Reynolds, Niamh Lynam-Lennon, Jacintha O'Sullivan

Biological and Physical Sciences Department Faculty Works

Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Previous work in our group has demonstrated that overweight/obese OAC patients have better responses to neoadjuvant therapy, but the underlying mechanisms are unknown. Unravelling the immune–metabolic signatures of adipose tissue may provide insight for this observation. We hypothesised that different metabolic pathways predominate in visceral (VAT) and subcutaneous adipose tissue (SAT) and inflammatory secretions will differ between the fat depots. Real-time ex vivo metabolic profiles of VAT and SAT from 12 OAC patients were analysed. These samples were screened for the secretion of 54 inflammatory mediators, and data were correlated …