Medicine and Health Sciences Commons^™

Comparison Of Medicaments Used In Regenerative Endodontics In Terms Of Dentin Microhardness And Adhesion Of Mineral Trioxide Aggregate, Esma Saricam, Neslihan Bulak, Esra Özyurt, Suat Özcan

Journal of Dentistry Indonesia

Eliminating microorganisms in the root canal system is important for the success of regenerative endodontics. Objective: This study evaluated the effects of different antibiotic pastes used for regenerative endodontic procedures on dentin microhardness and the push-out bond strength of mineral trioxide aggregate (MTA) to root canal dentin. Methods: Sixty-four maxillary central incisors were instrumented and randomly divided into the following four groups (n = 16) for medicament treatment: triple antibiotic paste, amoxicillin+clavulanic acid, cefaclor, and control (no dressing). After 21 days, two root segments were obtained by sectioning the roots horizontally for push-out and microhardness evaluations. MTA was placed into …

Clinically Relevant Interactions Between Atypical Antipsychotics And Anti-Infective Agents, Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose De Leon

Psychiatry Faculty Publications

This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed …

Sustainability Of An Outpatient Antibiotic Stewardship Program, Kristin Smith

Dissertations

Abstract

Problem: Antibiotic stewardship is an effort to evaluate and improve the use of antibiotics by providers and patients. Antibiotic stewardship programs (ASPs) promote the appropriate use of antibiotics. There is increasing evidence that supports the use of antibiotic stewardship programs in reducing antibiotic prescribing rates while continuing to maintain safe patient care. Research supports approaches with multiple interventions and ongoing commitment to antibiotic stewardship. However, information regarding long-term sustainability of antibiotic stewardship programs is lacking. The purpose of this quality assurance project was to assess long-term sustainability of a previously implemented ASP promoting appropriate prescribing of antibiotics for the …

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2019, Kayla R Stover, Elias B Chahine, David Cluck, Sarah Green, Daniel B Chastain, Darrell Childress, Carmen Faulkner-Fennell, Katherine Lusardi, Edo-Abasi U. Mcgee, Michelle Turner, P Brandon Bookstaver, Christopher M Bland

PCOM Scholarly Papers

Staying current on literature related to antimicrobial stewardship can be challenging given the ever-increasing number of published articles. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship-related peer-reviewed literature that detailed an actionable intervention for 2019. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training and to identify potential intervention opportunities within one's institution.

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2019, Kayla R. Stover, Elias B. Chahine, David Cluck, Sarah Green, Daniel B. Chastain, Darrell Childress, Carmen Faulkner-Fennell, Katherine Lusardi, Edoabasi U. Mcgee, Michelle Turner, P Brandon Bookstaver, Christopher M. Bland

Faculty Publications

Staying current on literature related to antimicrobial stewardship can be challenging given the ever-increasing number of published articles. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship-related peer-reviewed literature that detailed an actionable intervention for 2019. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training and to identify potential intervention opportunities within one's institution.

Availability Of Over-The-Counter Antibiotics In Guatemalan Corner Stores, Purificación Moreno, Alejandro Cerón, Karen Sosa, Marinees Morales, Laura M. Grajeda, Maria Renee Lopez, John P. Mccraken, Celia Cordón-Rosales, Guy H. Palmer, Douglas R. Call, Brooke M. Ramay

Anthropology: Faculty Scholarship

Widespread availability of antibiotics without prescription potentially facilitates overuse and contributes to selection pressure for antimicrobial resistant bacteria. Prior to this study, anecdotal observations in Guatemala identified corner stores as primary antibiotic dispensaries, where people purchase antibiotics without prescriptions. We carried out a cross sectional study to document the number and types of antibiotics available in corner stores, in four study areas in Guatemala. A total of 443 corner stores were surveyed, of which 295 (67%) sold antibiotics. The most commonly available antibiotics were amoxicillin, found in 246/295 (83%) stores, and tetracycline, found in 195/295 (66%) stores. Over the counter …

Patient Knowledge And Perception Regarding Antibiotic Misuse In Primary Care, Aimee Cockerham, Megan Mcdaniel, Hannah Mcmillin, Kelly Nash, April Robinson

MSN Research Projects

The Centers for Disease Control (CDC) and Prevention’s 2019 Antibiotic Resistant Threats Report shows that antibiotic-resistant bacteria and fungi cause more than 2.8 million infections and 35,000 deaths in the United States each year. This equates to at least one infection every 11 seconds and one death resulting from antibiotic resistance every 15 minutes. The CDC states that there were almost twice as many deaths each year from antibiotic resistance compared to statistics reported in 2013 (CDC, 2019a). Proper antibiotic use is the responsibility of the provider and the patient. Patient knowledge should consist of how to prevent antibiotic misuse, …

Prehospital Antibiotics Improve Morbidity And Mortality Of Emergency Medical Service Patients With Sepsis, Thomas Martel, Monica N. Melmer, Samuel M. Leaman, Nicole Kassen, Seth Kozlowski, Jonathan Pangia, Scott Gutovitz, Dietrich Jehle

HCA Healthcare Journal of Medicine

Background: Severe sepsis is a major cause of mortality in patients evaluated in the Emergency Department (ED). Early initiation of antibiotic therapy and IV fluids in the ED is associated with improved outcomes. We investigated whether early administration of antibiotics in the prehospital setting improves outcomes in these patients with sepsis.

Methods: This is a retrospective study comparing outcomes of patients meeting sepsis criteria in the field by EMS, who were treated with IV fluids and antibiotics. Their outcomes were compared with controls where fluids were administered prehospital and antibiotics were initiated in the ED. We compared morbidity and mortality …

A Multifocused Intervention To Reducing Antibiotic Prescribing In Uncomplicated Upper Respiratory Infections In The Urgent Care Setting, Chelsea Popp

Doctor of Nursing Practice Projects

Background: Upper respiratory infections (URIs) comprise a large amount of Urgent Care visits. Though certain patients with URIs may require antibiotic intervention, the majority of patients are considered uncomplicated. Inappropriate prescribing of antibiotics has a direct association to antibiotic resistant bacteria and increased patient mortality (Harris, et al., 2016). Antibiotics are prescribed for more than half of URI’s presenting to Urgent Care clinics.

Purpose: The purpose of this quality improvement project is to determine if proper education on current evidence-based practice guidelines for both the patient and provider will result in a reduction in the number of antibiotics prescribed for …

And This Too Shall Pass …!, Sunil R

Manipal Journal of Medical Sciences

No abstract provided.

Lowering Antibiotic Resistance Utilizing Breastmilk, Moriah J. Harris

Honors College Theses

Antibiotic resistance is considered an emerging crisis in the healthcare world. This crisis has the potential to cause many bacterial diseases that cannot be cured using antibiotic drugs, which can lead to serious infections and death. There have been numerous studies that have found that sugars, proteins and protein-lipid complexes in breastmilk have antimicrobial properties. It has been proposed that these properties in breastmilk can help solve the antibacterial resistance crisis. This research project involved studying antibiotic resistance and how breastmilk can help solve this increasingly prevalent problem.

The implementation step of this research project involved a PowerPoint presentation detailing …

The Social Dynamics Of Antibiotic Use In A Large American Medical Complex, Katharina Rynkiewich

Arts & Sciences Electronic Theses and Dissertations

Based on 18 months of anthropological fieldwork, 35 in-depth interviews, and over 360 hours of participant observation with two specialty physician groups, my dissertation is an analysis of the social dynamics involved in antibiotic decision making, prescription, and use at a large North American medical complex in a Midwestern city. Due to the global problem of antimicrobial resistance, hospitals have been particularly interested in reducing antibiotic overuse and misuse. Though the use of antibiotics has long had an impact at the population level, physicians often advocate for additional antibiotic coverage in the individual patient. I examine a policy aimed at …

Design And Synthesis Of Novel Analogs As Potential Antitubercular Agents, Peggy Mccluggage

Honors Theses

Tuberculosis (TB) is an infectious, airborne disease which primarily infects the lungs. One-third of the world’s population is currently estimated to be infected with Mycobacterium tuberculosis (Mtb), the causative agent for TB [1]. Current treatment for this disease requires at least six months of taking multiple antibiotics with undesirable side effects [2]. Difficulty in complying to this regimen as well as the prevalence of HIV/AIDS has led to antimicrobial resistance seen in Mtb. In order to combat the Multi-Drug Resistant and Extensively-Drug Resistant strains of the disease-causing bacteria, preventative care and novel antibiotics are urgently needed [3]. The purpose for …

A Systematic Search And Review On The Efficacy, Safety, And Cost-Effectiveness Of Utilizing Lactobacillus Probiotics In Concurrence With Prescribing Antibiotics To Reduce Clostridium Difficile Infection Rates In Hospitalized Patients, Laura Sheehan

Nursing Masters Papers

Incidence of Clostridium difficile infection, (CDI) in patients receiving antibiotics is significant. In 2017, there were approximately 223,900 cases of CDI in hospitalized patients alone (Center for Disease Control [CDC], 2017). Despite enhanced infection control measures, CDI rates remain prevalent and are associated with increased costs to healthcare. An integrative literature review and synthesis was performed. Studies were analyzed to delineate if Lactobacillus containing probiotics, when administered concurrently with high risk antibiotics, decrease CDI rates for patients in the inpatient hospital setting. Additional analysis of probiotic safety and a cost versus benefit analysis was researched. The purpose of the review …

Pseudomonas And Bacillus As Potential Sources Of Novel Antibiotics, Cory Jayne, Dr. Lori Scott

Identifying and Characterizing Novel Antibiotic Producing Microbes From the Soil

With an increase in antibiotic resistance within the medical field the need for novel antibiotics is evident. Through collaboration with the Tiny Earth Project Initiative, we hope to find novel antibiotics through bacteria found in soil. We were able to successfully isolate two microbes that showed broad spectrum antibiotics against both Staphylococcus epidermis and Bacillus subtilis. Through further exploration and collaboration with the Tiny Earth Project Initiative, we might be able to discover novel antibiotics.

Frontotemporal Dementia Nonsense Mutation Of Progranulin Rescued By Aminoglycosides, Lisha Kuang, Kei Hashimoto, Eric J. Huang, Matthew S. Gentry, Haining Zhu

Molecular and Cellular Biochemistry Faculty Publications

Frontotemporal dementia (FTD) is an early onset dementia and is characterized by progressive atrophy of the frontal and/or temporal lobes. FTD is highly heritable with mutations in progranulin accounting for 5-26% of cases in different populations. Progranulin is involved in endocytosis, secretion and lysosomal processes, but its function under physiological and pathological conditions remains to be defined. Many FTD-causing nonsense progranulin mutations contain a premature termination codon (PTC), thus progranulin haploinsufficiency has been proposed as a major disease mechanism. Currently, there is no effective FTD treatment or therapy.

Aminoglycosides are a class of antibiotics that possess a less known function …

Antibiotics Gone Viral: Reduce Their Use For Acute Bronchitis, Esther Steinhaus

Student Research Poster Presentations 2020

Antibiotic resistance has become a global health crisis. Providers contribute to this crisis by inappropriately prescribing antibiotics causing an increase in the number of drug resistant organisms. The leading cause of inappropriate antibiotic prescriptions in the primary care setting are upper respiratory tract infections, primarily acute bronchitis. The purpose of this evidence-based practice project is to determine if an educational program for primary care providers regarding appropriate use of antibiotics will reduce the number of antibiotic prescriptions issued for acute bronchitis. The following PICOT question was developed to guide this evidence-based practice project: “Among primary care providers treating adults in …

Improving Early Antibiotic Administration For Treatment Of Sepsis At Children’S Hospital Of Richmond At Vcu: 2012-2019, Hannah Miller Md, Ashlie Tseng Md, Perry Taylor Pharmd, Matthew Schefft Do Msha, Sheila Pedigo Pharmd Bcpps, Tracy Lowerre Bsn Ms, Jose Munoz Md, Mark Astoria Md, Jonathan Silverman Md Mph

Graduate Medical Education (GME) Resident and Fellow Research Day Posters

Background: The Surviving Sepsis Campaign recommends initiating IV antibiotic administration within one hour of recognition of severe sepsis. Several studies have shown that prompt blood culture collection, administration of broad-spectrum antibiotics, and fluid resuscitation following recognition improves child survival.

Objective: Our goal was to evaluate effectiveness of sepsis initiatives and institutional changes in the timing of early antibiotic administration at Children’s Hospital of Richmond at VCU.

Methods: We formed a Pediatric Sepsis Committee with representatives from each unit in 2013. In 2016, the committee began tracking time from the order of a first stat dose IV antibiotic to administration as …

Evaluation Of Inappropriate Use Of Antibiotics In The Long-Term Care Community, Charlene A. Hughes

Walden Dissertations and Doctoral Studies

The number of antibiotics prescribed in the 65 and older population significantly increased related to the diagnosis of urinary tract infections (UTIs). Although empiric treatment is necessary at times, it can lead to antibiotic resistance; therefore, clinical symptomology with an active infection verified by diagnostic testing is the requirement for the treatment of a UTI. This project addressed the practice-focused question of how the implementation of an evidenced-based antibiotic stewardship program (ASP) in a nursing home on the East Coast may impact the overuse of antibiotics in that clinical setting. The project, guided by the theory of planned behavior, was …

Evaluating The Impact Of Verigene® Organism Identification On Antimicrobial Stewardship Recommendations, Rebecca Gerske

Undergraduate Honors Thesis Collection

Verigene® is one of many commercially available rapid diagnostic tests (RDT) for organism identification in blood culture. Community Health Network (CHNw) utilizes this system to identify blood cultures and guide antimicrobial therapy. As antibiotic resistance becomes more and more prevalent, limiting exposure to broad-spectrum antibiotic therapy is of paramount importance. RDT provides more timely information to providers, which if utilized appropriately, can result in the patient receiving appropriate antibiotic therapy in a shorter time and further limits unnecessary antibiotic exposure. This study was a three-part, retrospective chart review to determine the microbiological accuracy of Verigene® within CHNw and evaluate the …

Antifungal Defense Molecules From Bacterial Symbionts Of North American Trachymyrmex Ants, Georgia Scherer

CMC Senior Theses

Defensive symbioses, in which microbes provide molecular defenses for an animal host, hold great potential as untapped sources of therapeutically useful antibiotics. Fungus-growing ants use antifungal defenses from bacterial symbionts to suppress pathogenic fungi in their nests. Preliminary chemical investigations of symbiotic bacteria from this large family of ants have uncovered novel antifungal molecules with therapeutic potential, such as dentigerumycin and selvamicin.

In this study, the bacterial symbionts of North American Trachymyrmex fungus-growing ants are investigated for antifungal molecules. Plate-based bioassays using ecologically-relevant fungal pathogens confirmed that these bacteria have antifungal activity. In order to purify and identify the antifungal …

A Reevaluation Of The Importance Of Timing To Antibiotic Administration In Patients With Sepsis And Septic Shock In The Emergency Department, Melissa Yoon

Capstone Showcase

Sepsis is a life threatening organ dysfunction that is caused by the body’s dysregulated response to an infection. A crucial component of treatment includes intravenous antibiotic administration and is recommended within 1 hour of suspected sepsis. However, research conducted over the past two decades have produced mixed results regarding the relationship between mortality rates and this 1 hour time limit. In light of issues such as increasing antibiotic resistance and limited resources in emergency departments, this study reviewed current literature to critically evaluate the effects of modest delays in antibiotic administration in sepsis and septic shock. The studies suggest that …

Gut Microbiota And Therapeutic Approaches For Dysbiosis In Irritable Bowel Syndrome:Recent Developments And Future Perspectives, Hanna Fjeldheim Dale, Gülen Arslan Lied

Turkish Journal of Medical Sciences

Increased knowledge regarding the implications of gut microbiota in irritable bowel syndrome (IBS) suggests that a disturbed intestinal microenvironment (dysbiosis) might promote the development and maintenance of IBS symptoms and affects several pathways in the pathology of this multifactorial disease. Accordingly, manipulation of the gut microbiota in order to improve IBS symptoms has evolved as a novel treatment strategy in the last decade. Several different approaches have been investigated in order to improve the gut microbiota composition. Dietary modifications including supplementation with fibers, prebiotics, and probiotics are shown to improve symptoms and composition of gut microbiota in IBS; however, the …