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Full-Text Articles in Medicine and Health Sciences
Change In Processing Speed And Its Associations With Cerebral White Matter Microstructure, Muzamil Arshad
Change In Processing Speed And Its Associations With Cerebral White Matter Microstructure, Muzamil Arshad
Wayne State University Dissertations
The decline of cognition with age is one of the most feared aspects of aging, while the slowing of responses, or reduced processing speed, is one of the most reliable aspects of aging. Slowing of processing has been hypothesized to affect other domains of cognition as well. Despite the well-known slowing-age relationship and central position processing speed plays in theories of cognitive aging the neurobiological mechanisms which underpin slowing is unclear. If we could identify the biology associated with processing speed we could then attempt to develop interventions to mitigate the effects of age on those variables. In turn we …
Utilization Of Structural And Biochemical Cues To Enhance Peripheral Nerve Regeneration, Balendu Shekhar Jha
Utilization Of Structural And Biochemical Cues To Enhance Peripheral Nerve Regeneration, Balendu Shekhar Jha
Theses and Dissertations
This study examines the prospects of using the electrospinning process to fabricate tissue engineering scaffolds targeting a variety of regenerative applications, with a primary focus on the production of nerve guides for the treatment of long-defect nerve injuries in the peripheral nervous system. A basic overview of the conventional electrospinning process is provided, and the utility of this fabrication scheme in the production of collagen-based tissue engineering scaffolds is demonstrated. Next, a novel modification of the basic electrospinning process is presented. This process, called two pole air gap electrospinning, was developed to produce nerve guides that exhibit an anisotropic structure …
The Role Of Matrix Metalloproteinases In Axon Guidance And Neurite Outgrowth, Lu Anne Velayo Dinglasan
The Role Of Matrix Metalloproteinases In Axon Guidance And Neurite Outgrowth, Lu Anne Velayo Dinglasan
Yale Medicine Thesis Digital Library
Axons navigating the complex environment of the developing CNS use extracellular guidance cues to help find their correct synaptic target. Matrix metalloproteinases (MMPs), a family of zinc-dependent proteolytic enzymes, have been shown to regulate axon guidance by degrading extracellular matrix (ECM) or by cleaving guidance cues and their receptors. The olfactory system is an excellent model for studying the role of MMPs in axon guidance due to its capacity for continuous nerve regeneration and topographic maintenance during synaptic targeting. I hypothesized that MMPs may play a role in guiding olfactory sensory neurons to their correct glomerular target by sculpting the …