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Full-Text Articles in Medicine and Health Sciences
Tissue-Engineered Grafts: The Future Of Anterior Cruciate Ligament Reconstructive Surgery, Amber Braxton
Tissue-Engineered Grafts: The Future Of Anterior Cruciate Ligament Reconstructive Surgery, Amber Braxton
BIO 410 Spring 2019 Research Papers
Anterior cruciate ligament (ACL) ruptures are common injuries, specifically for young athletes, and in order to repair this injury, the patients must undergo ACL reconstructive surgery. This surgery commissions the use of autografts and allografts in order rebuild the torn ligament. Traditional autografts are the patellar tendon autograft, which is the most common, and the hamstring autograft. These grafts are made by transplanting tissue from the patellar tendon or the hamstring to the ruptured ACL. Allografts are another type of graft that involves transplanting tissue from a donor cadaver to the patient. Traditional autografts and allografts have been used for …
Development Of A Mel Cell-Derived Allograft Mouse Model For Cancer Research, Min Young Kim, Sungwoo Choi, Seol Eui Lee, Ji Sook Kim, Seung Han Son, Young Soo Lim, Bang-Jin Kim, Buom-Yong Ryu, Vladimir N. Uversky, Young Jin Lee, Chul Geun Kim
Development Of A Mel Cell-Derived Allograft Mouse Model For Cancer Research, Min Young Kim, Sungwoo Choi, Seol Eui Lee, Ji Sook Kim, Seung Han Son, Young Soo Lim, Bang-Jin Kim, Buom-Yong Ryu, Vladimir N. Uversky, Young Jin Lee, Chul Geun Kim
Molecular Medicine Faculty Publications
Murine erythroleukemia (MEL) cells are often employed as a model to dissect mechanisms of erythropoiesis and erythroleukemia in vitro. Here, an allograft model using MEL cells resulting in splenomegaly was established to develop a diagnostic model for isolation/quantification of metastatic cells, anti-cancer drug screening, and evaluation of the tumorigenic or metastatic potentials of molecules in vivo. In this animal model, circulating MEL cells from the blood stream were successfully isolated and quantified with an additional in vitro cultivation step. In terms of the molecular-pathological analysis, we were able to successfully evaluate the functional discrimination between methyl-CpG-binding domain 2 (Mbd2) and …