Medicine and Health Sciences Commons^™

A Somatic Mutation In Moesin Drives Progression Into Acute Myeloid Leukemia, Ouyang Yuan, Jeffrey A Magee, Et Al.

Open Access Publications

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed human AML samples is challenging, if at all possible. Here, we approached this question using a murine in vivo model with an MLL-ENL fusion protein as a primary molecular event. Upon clonal transformation, we identified and extensively verified a recurrent codon-changing mutation (Arg

Segmental Colitis Associated With Diverticulosis Masquerading As Polyploid-Appearing Mucosa In The Rectosigmoid Area On Endoscopy And As Focal Thickening On Imaging, Eugene C. Nwankwo Jr, Gebran Khneizer, Gregory Sayuk, Jill Elwing, Necat Havlioglu, Michael Presti

Open Access Publications

Segmental colitis associated with diverticulosis (SCAD) is an inflammatory disease affecting segments of the large bowel with diverticular disease. SCAD presents several challenges in diagnoses and treatment because it often mimics a range of disorders including inflammatory bowel disease and malignancy. Here, we present the case of a 72-year-old man with lower abdominal pain and bloody stools whose initial abdominal workup showed nonspecific large bowel thickening and concerns for malignancy. Ultimately, the patient was diagnosed with mild SCAD and treated conservatively with a resolution of symptoms. He had no symptoms at the three-month and 1-year follow-ups. This case highlights the …

Fragile X Mental Retardation Protein And Cerebral Expression Of Metabotropic Glutamate Receptor Subtype 5 In Men With Fragile X Syndrome: A Pilot Study, James Robert Brašić, Jack Alexander Goodman, Ayon Nandi, David S Russell, Danna Jennings, Olivier Barret, Samuel D Martin, Keith Slifer, Thomas Sedlak, Anil Kumar Mathur, John P Seibyl, Elizabeth M Berry-Kravis, Dean F Wong, Dejan B Budimirovic

Open Access Publications

Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein (FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR

Activation Of The Α1Β2Γ2l Gaba Receptor By Physiological Agonists, Spencer R Pierce, Allison L Germann, Gustav Akk

Open Access Publications

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Development And Genetics Of Red Coloration In The Zebrafish Relative Danio Albolineatus, Delai Huang, Victor M. Lewis, Tarah N. Foster, Matthew B. Toomey, Joseph C. Corbo, David M. Parichy

Open Access Publications

Animal pigment patterns play important roles in behavior and, in many species, red coloration serves as an honest signal of individual quality in mate choice. Among

Academic Performance Of Children With Sickle Cell Disease In The United States: A Meta-Analysis, Andrew M Heitzer, Latacha Hamilton, Claire Stafford, Jeffrey Gossett, Lara Ouellette, Ana Trpchevska, Allison A King, Guolian Kang, Jane S Hankins

Open Access Publications

No abstract provided.

2019 Hrs/Ehra/Aphrs/Lahrs Expert Consensus Statement On Catheter Ablation Of Ventricular Arrhythmias: Executive Summary, Edmond M Cronin, Phillip Cuculich, Et Al

Open Access Publications

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these procedures in a document that will update and replace the …

Genomic Profiling Of Circulating Tumor Dna From Cerebrospinal Fluid To Guide Clinical Decision Making For Patients With Primary And Metastatic Brain Tumors, Lori A Ramkissoon, Sonika Dahiya, Et Al.

Open Access Publications

Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished …

Gantenerumab Reduces Amyloid-Β Plaques In Patients With Prodromal To Moderate Alzheimer's Disease: A Pet Substudy Interim Analysis, Gregory Klein, Paul Delmar, Nicola Voyle, Sunita Rehal, Carsten Hofmann, Danielle Abi-Saab, Mirjana Andjelkovic, Smiljana Ristic, Guoqiao Wang, Randall Bateman, Geoffrey A Kerchner, Monika Baudler, Paulo Fontoura, Rachelle Doody

Open Access Publications

BACKGROUND: We previously investigated low doses (105 or 225 mg) of gantenerumab, a fully human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor-mediated phagocytosis, in the SCarlet RoAD (SR) and Marguerite RoAD (MR) phase 3 trials. Several lines of evidence suggested that higher doses may be necessary to achieve clinical efficacy. We therefore designed a positron emission tomography (PET) substudy to evaluate the effect of gantenerumab uptitrated to 1200 mg every 4 weeks on amyloid-β plaques as measured using florbetapir PET in patients with prodromal to moderate Alzheimer's disease (AD).

METHODS: A subset of patients enrolled in …

Are The Intrinsically Disordered Linkers Involved In Ssb Binding To Accessory Proteins?, Min Kyung Shinn, Alexander G. Kozlov, Bihn Nguyen, Wlodek M. Bujalowski, Timothy M. Lohman

Open Access Publications

No abstract provided.

2019 Hrs/Ehra/Aphrs/Lahrs Expert Consensus Statement On Catheter Ablation Of Ventricular Arrhythmias, Phillip Cuculich, Et Al

Open Access Publications

No abstract provided.

Blood-Brain Barrier-Associated Pericytes Internalize And Clear Aggregated Amyloid-Β42 By Lrp1-Dependent Apolipoprotein E Isoform-Specific Mechanism, Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman, Berislav V. Zlokovic

Open Access Publications

No abstract provided.

The Use Of Live Attenuated Influenza Vaccine (Laiv) In Healthcare Personnel (Hcp): Guidance From The Society For Healthcare Epidemiology Of America (Shea), Thomas R. Talbot, Hilary Babcock, Deborah Cotton, Lisa L. Maragakis, Gregory A. Poland, Edward J. Septimus, Michael L. Tapper, David J. Weber

Open Access Publications

No abstract provided.

Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs

Open Access Publications

No abstract provided.

Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig

Open Access Publications

No abstract provided.

Intermediate Outcomes Following Percutaneous Fixation Of Proximal Humeral Fractures, Alicia K. Harrison, Konrad I. Gruson, Benjamin Zmistowski, Jay Keener, Leesa Galatz, Gerald Williams, Bradford O. Parsons, Evan L. Flatgow

Open Access Publications

No abstract provided.

Diagnostic Performance And Reliability Of Ultrasonography For Fatty Degeneration Of The Rotator Cuff Muscles, Lindley B. Wall, Sharlene A. Teefey, William D. Middleton, Nirvikar Dahiya, Karen Steger-May, H. Mike Kim, Daniel Wessell, Ken Yamaguchi

Open Access Publications

No abstract provided.

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.

Vascular Anatomy Of The Tibiofibular Syndesmosis, Kathleen E. Mckeon, Rick W. Wright, Jeffrey E. Johnson, Jeremy J. Mccormick, Sandra E. Klein

Open Access Publications

No abstract provided.

Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo

Open Access Publications

No abstract provided.

Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall

Open Access Publications

No abstract provided.

Molecular Analysis Of Age And Sex-Related Gene Expression In Meniscal Tears With And Without A Concomitant Anterior Cruciate Ligament Tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J. Sandell

Open Access Publications

No abstract provided.

Lower Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Sandra E. Klein, John C. Clohisy, Geneva R. Baca, Robert H. Brophy, Rick W. Wright

Open Access Publications

No abstract provided.

Upper Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Ryan P. Calfee, Keith M. Baumgarten, Robert H. Brophy, Rick W. Wright

Open Access Publications

No abstract provided.

The Impact Of Mild Stroke On Participation In Physical Fitness Activities, Mary Hildebrand, Megan Brewer, Timothy Wolf

Open Access Publications

No abstract provided.

Evidence Of Differential Allelic Effects Between Adolescents And Adults For Plasma High-Density Lipoprotein, Rita Ps Middelberg, Andrew C. Heath, Pamela Af Madden, Grant W. Montgomery, Nicholas G. Martin, John B. Whitfield

Open Access Publications

No abstract provided.

Influence Of Primary Care Physician Availability And Socioeconomic Deprivation On Breast Cancer From 1988 To 2008: A Spatio-Temporal Analysis, Lung-Chang Chien, Anjali D. Deshpande, Donna B. Jeffe, Mario Schootman

Open Access Publications

No abstract provided.

A Critical Cell-Intrinsic Role For Serum Response Factor In Glial Specification In The Cns, Paul P.Y. Yu, Narendrakumar Ramanan

Open Access Publications

No abstract provided.

A Cross-Species Analysis Of Micrornas In The Developing Avian Face, Kara E. Powder, Yuan-Chieh Ku, Samantha A. Brugmann, Rose A. Veile, Nicole A. Renaud, Jill A. Helms, Michael Lovett

Open Access Publications

No abstract provided.

Ligand-Induced Movements Of Inner Transmembrane Helices Of Glut1 Revealed By Chemical Cross-Linking Of Di-Cysteine Mutants, Mike Mueckler, Carol Makepeace

Open Access Publications

No abstract provided.