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Full-Text Articles in Medicine and Health Sciences
Risperidone And Its Deconstructed Analogs: Functional Effects On The 5ht2ar, Sneha Shah
Risperidone And Its Deconstructed Analogs: Functional Effects On The 5ht2ar, Sneha Shah
Theses and Dissertations
G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that sense extracellular signal and activate intracellular signaling pathways. The serotonin 5HT2A receptor (or 2AR) is one of the GPCRs coupled to Gq proteins, activating PLC and hydrolyzing PIP2. This hydrolysis causes a diffusion of bound PIP2 away from the channel binding site resulting in G protein-gated inwardly rectifying K+ channel (GIRK) inhibition and a downstream stimulation of Ca2+ release from endoplasmic reticulum stores. Previous experiments have demonstrated that the serotonin 5HTA receptor is a target of serotonergic psychedelic drugs, such as LSD, and partially mediates the action of many …
Effects Of Dietary Preference On The Experience Of Anxiety, Depression And Acute Stress Response, Shaun Stearns
Effects Of Dietary Preference On The Experience Of Anxiety, Depression And Acute Stress Response, Shaun Stearns
Theses and Dissertations
Research has demonstrated that high saturated fat and low carbohydrate consumption may provide physiological benefit in the treatment of major neurological disorders, though not much research has explored if these benefits extend to the experience of anxiety, depression, stress and physical symptoms. The purpose of this study was to explore the relationship between fat consumption and negative emotional/physiological states (anxiety, depression, stress and physical symptoms). This study also explored how fat consumption can alter one's response to an acute stress. Participants completed an online survey indicating their food preferences and their responses to a number of self-report scales such as …
The Effect Of Simulated Nodules On Vocal Fold Movement In A Two Layer Synthetic Model, Rachelle Nevitt Rauma
The Effect Of Simulated Nodules On Vocal Fold Movement In A Two Layer Synthetic Model, Rachelle Nevitt Rauma
Theses and Dissertations
This study examined the differences between normal vocal fold vibration and the movement patterns of vocal folds with mass lesions by means of a synthetic model. The experimenter molded and cast three sets of vocal folds, representing normal structure, small nodules, and larger nodules. Acoustic, aerodynamic, and digital video signals were recorded and analyzed in order to quantify air flow and pressure, measure vibratory stability, and visually assess closure patterns across the three structural conditions. Statistical analysis revealed that the presence of vocal nodules resulted in a significantly higher onset pressure, fundamental frequency, airflow at onset, and offset pressure. However, …