Medicine and Health Sciences Commons^™

Modulating The Tumor Microenvironment To Improve Immunotherapy Treatments, Lleayem Nazario-Johnson, David Rowley

Senior Honors Projects

Advances in immunotherapy are revolutionizing the treatments of certain cancers, especially those in the blood. However, wider applications for eradicating solid tumors have been slow to emerge. A likely reason is the presence of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment that secrete immunosuppressive molecules which attenuate the attack of immune cells. We hypothesize that small molecule Wnt/Beta- Catenin inhibitors can be used to modulate the immunosuppressive actions of MDSCs and increase the effectiveness of immunotherapy treatments, such as with chimeric antigen receptor (CAR) T-cells. The Wnt/Beta-Catenin Pathway has been shown to be a crucial driving force behind the …

Impact Of Covid-19 Related Deaths On New Nurses In Rhode Island, Jessica Petonak

Senior Honors Projects

The purpose of this project was to identify the impact that COVID-19 related deaths have had on nurses with limited bedside experience in the state of Rhode Island. Exploring the level of preparedness that nurses felt to deal with death can provide insight into nursing and employer education. Hearing about nurses’ experiences during the pandemic helps illustrate the current state of nurses’ mental health. Gaining a better understanding of the amount and types of support that nurses on the frontlines are receiving can identify current gaps and potential areas of improvement. I found that the COVID-19 pandemic and related deaths …

An Intersectional Analysis Of Lgbtq+ Healthcare In The United States, Nicole Niles

Senior Honors Projects

LGBTQ+ healthcare has made some significant progress in the last few decades, yet countless studies have shown that the American healthcare system still lags behind in equitable healthcare. My project sought to identify the issues that prevent the LGBTQ+ community from receiving quality healthcare, which involved the curation of over twenty academic journal articles for an annotated bibliography, along with a paper discussing these articles.

One of the most important concepts to gender studies is intersectionality. Coined by legal theorist Kimberlé Crenshaw in 1989, intersectionality describes the concept of how one’s individual characteristics, including race, class, and gender, intersect and …

The Public Health Crisis Of Alcoholism: What Could Be Done Better In Rhode Island?, Carlos Borges

Senior Honors Projects

Alcoholism is a chronic issue that affects over 3 million people per year in the United States. It is characterized by an individual who is physiologically dependent on alcohol to the point where they cannot carry out common social activities such as having friends or holding down a job. Approximately 88,000 people die per year due to alcohol related events. The economic impact due to hospital bills, criminal justice costs, and lost productivity of the abuser is estimated at $400 billion annually. Alcohol abuse can be used as a coping mechanism in adolescents who are struggling with behavioral health issues …

Dialectical Behavior Therapy For Dual Diagnosis: Treating Adolescent Substance Use Disorder And Co-Occurring Mood Disorders, Melody R. Gately

Senior Honors Projects

No abstract provided.

On The Front Line: Uri's Response To Covid-19 And The Role Of The Student-Run Emergency Medical Services, Michael C. Brennan

Senior Honors Projects

The COVID-19 pandemic has affected all aspects of society, including universities, and we are just beginning to understand its impacts. This project looks at how universities have responded to the pandemic by focusing on the University of Rhode Island, the largest university in the state of Rhode Island. A key aspect of this project is a timeline that documents the policies implemented by URI leadership and relevant policies adopted by the State of Rhode Island. The timeline also includes data about the number of cases at URI and state-wide, as well as figures for the number of students in isolation …

Climate Change And Vaccines: Distrust Of Science In Politics And The Media, Natalie Montalbano

Senior Honors Projects

Distrust in science and the scientific process has increased significantly over the last fifty years, and this distrust is particularly apparent in the fields of climate change and vaccination. Climate change, a relatively new scientific issue, has become one of the hottest topics discussed in both U.S and world politics. The existence and real threat of anthropogenic global warming was publicly declared by National Geographic in 2004, but climate scientists had acknowledged that humans were causing the warming of our Earth as early as the 1980’s. Vaccines, despite being safe and effective in curbing the spread of infectious diseases, have …

A Story Told, Carly Caldarella

Senior Honors Projects

How do we educate our future generations about topics that are difficult to discuss? Oftentimes, children ask us questions that make us think, "How do I respond to this?" It is essential for our young generations to understand the history of racism, its present manifestations, and solutions and methods of action in order for a bright and revolutionary future. It is not always a simple task for children to comprehend such intricate topics. However, through text and pictures in storybooks, children can better grasp the concepts of such subject matter. "A Story Told" shares the story of young children in …

Social Justice Attitudes And Health: A Cross Sectional Study, Edward Donovan

Senior Honors Projects

Background: Increasingly, social justice is being considered as a key factor associated with health outcome. In addition, there is growing interest in exploring perception of discrimination in healthcare settings. This study explored perceptions of social justice, health care discrimination, health care status and utilization of healthcare resources. The investigators predict a significant association between the level of social justice awareness and healthcare utilization based on the hypothesis that those who are cognizant of social inequities are more likely to be informed self-advocates in healthcare settings.

Methods: First, a survey was created based on a review of existing literature. The …

Examination Of The Effects Of Speech Disorders On Juvenile Delinquency And The Potential Benefits Of Speech Therapy For Offenders, Katie Paparelli

Senior Honors Projects

In the United States, there are currently over 50,000 juveniles housed in youth confinement facilities for delinquent acts ranging from truancy to murder. To decrease that number, it is pertinent to identify possible risk factors of juvenile delinquency, but also to establish impactful preventative strategies as well as reactive solutions. Speech disorders and speech differences have been identified as potential risk factors for juvenile delinquency. Having a speech disorder/difference has an undeniable impact on a child’s life, with potentially negative impacts ranging from poor engagement with school and bullying—both risk factors in themselves for juvenile delinquency. Unsurprisingly, researchers have found …

Health Communication Support In Baseline Health Literacy Research, Owen Manahan

Senior Honors Projects

Health literacy refers to the ability to obtain, understand, and use health information to make good health decisions. Improving health outcomes in Rhode Island requires removing health literacy barriers.

In the spring of 2019, researchers at the University of Rhode Island and Rhode Island College received funding from the Rhode Island Executive Office of Health and Human Services to assess health literacy in Medicaid beneficiary outpatient health centers. Such research has never before been conducted in Rhode Island. Researchers administered a modified health literacy assessment to collect self-reported data on patient health status, measure patient confidence in accessing health information, …

Ethnic And Racial Disparities In Covid-19 Infections In The United States������ ��� ������ ����������� �� �������� ���������� �� ��� ������ ��, Seraphina Negash

Senior Honors Projects

No abstract provided.

Project Title: Home Birthing: Analyzing The Value Of Home Births To American Mothers, Julia Santini

Senior Honors Projects

There were about 3.7 million births in the United States in 2018, and a maternal mortality rate of 17.4 deaths per 100,000 live births (37.3 for non-Hispanic black women). The US also has high rates of birth interventions such as episiotomy and instrumental vaginal births, and increasing rates of cesarean sections, and while these interventions can be life saving, they do not always result in better birth outcomes. When the high US maternal mortality rates are compared to those of peer countries such as Canada and the UK, the data suggests that there is much room for improvement in how …

Comparative Gait Analysis Of Transtibial Amputees Versus, Charlotte Vitale

Senior Honors Projects

While individuals with lower limb prosthetics make up a very small percentage of the population, their musculoskeletal deformities impair their abilities to produce “normal” biomechanical actions. The deviations in their walking patterns can further inhibit their efficacy in other activities of basic living. Understanding the distinct kinematic comparisons during gait between lower limb amputees and able-bodied individuals is critical for those planning to enter such a field of study working with this specific population. As an aspiring specialized Physical Therapist, it is very likely that I will be assisting clients to regain a healthy walking pattern after a traumatic accident, …

Exploring The Associations Between Femininity, Burnout, And Health Behaviors Among Middle Age Women, Adelaide Brown

Senior Honors Projects

To date research on how traditional feminine traits and gender role ideology may impact burnout and health behaviors in women is limited. This paper examines how the aforementioned may be associated with higher burnout rates in a community-based cohort of middle-aged women (40-65 years). This study focuses on western traditional feminine traits and gender role ideology, which describe an individual's attitude regarding their assigned role in society and the strength of association with their role. Women who report a stronger connection to more traditional traits or ideology were expected to report higher rates of burnout.

This study also assesses whether …

The Association Between Type-2 Diabetes Pathophysiology & Exercise Adherence, Sydney Raymond

Senior Honors Projects

According to the American Diabetes Association, 1 in 3 Americans will be diagnosed with diabetes. While some of these individuals will be prescribed medications as part of their treatment, most will also be advised to begin an exercise program to assist with blood glucose control. Additionally, while regular exercise is associated with lower HbA1C and decreased insulin/medication dependence, it is estimated that only about half of those diagnosed with diabetes will adhere to their exercise plans. Social, psychological, and physiological factors all play roles in affecting ones ability to adhere to an exercise regiment, and individuals with Type 2 Diabetes …

A University Forest Fire: Examining The Spread Of The Coronavirus Through College Social Networks Using A Modified Forest Fire Probabilistic Model, Raechel Griffin

Senior Honors Projects

No abstract provided.