Medicine and Health Sciences Commons^™

Body Mass Index Does Not Predict Injury Pattern Or Outcome After Motorcycle Crash, Madison E. Morgan, Lindsay Periera, Anthony Allsbrook, Jennifer Q. To, Odessa R. Pulido, Hannah Shin, Alison Muller, Adrian Ong, Christopher A. Butts, Maxwell A. Braverman

Research Day

Introduction: The obesity epidemic plagues the United States, affecting approximately 42% of the population. The relationship of obesity with injury severity and outcomes has been poorly studied among motorcycle collisions (MCC). This study aimed to compare injury severity, mortality, injury regions, and hospital and intensive care unit length of stay (LOS) between obese and normal-weight MCC patients.

Methods: Trauma registries from three Pennsylvania Level 1 trauma centers were queried for adult MCC patients (January 1, 2016-December 31, 2020). Obesity was defined as adult patients with body mass index 30 kg/m2 and normal weight was defined as body mass index/m2 but …

Childhood Obesity Treatment And Approach Quality Improvement Project, Kimberly Townsend, Autumn Dye

Research Day

Introduction

Childhood obesity has become an important public health issue in the United States. Obesity is defined as a BMI at or above the 95th percentile for age and sex. Childhood obesity can be associated with many comorbidities and adverse effects, including type 2 diabetes, hypertension, nonalcoholic fatty liver disease, obstructive sleep apnea, and dyslipidemia.

Methods

The data was taken from data collected throughout 2023 and 2024 from the AAP QI project on childhood obesity and treatment. The data was collected from charts at PCOM’s Lancaster Avenue clinic. Additional methods will include a literature review to outline the importance of …

Magnetic Drug Delivery Of Xanthohumol To Adipocytes Using Ultrasmall Superparamagnetic Iron Oxide Nanoparticles., Irandokht Khaki Najafabadi, Janaiya Samuels, Royce Dansby-Sparks, Srujana Rayalam, Vicky Mody

Research Day

According to the CDC’s National Center for Health Statistics, more than one-third (36.5%) of U.S adults are obese. It is the main risk factor for type-2-diabetes, hypertension, dyslipidemia and atherosclerosis. Nutraceuticals such as Xanthohumol have shown potential to inhibit adipogeneis, however, their bioavailability has remained controversial. Hence there is a need to develop targeted therapy which will increase the concentration of Xanthohumol on adipose tissues. Currently, magnetic drug delivery has been used to develop targeted therapies where conventional therapies have proven to be less effective. Among various types of nanoparticles ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) have found considerable attention …

Phytochemicals Added To The Feed Of Ovariectomized Adult Rats Increase Brown Adipose Activity, Colette N. Miller, Suresh Ambati, Erica Bass, Natalie Hohos, Diane Hartzel, Emily England, Mary Anne Della-Fera, Srujana Rayalam, Clifton A. Baile

Research Day

Background: Brown adipose tissue (BAT) uncouples respiration, using lipids as an energy source while dissipating heat. Increases in BAT activity are protective against obesity, thus compounds that increase BAT activation may help prevent weight gain. Resveratrol (R) increases BAT activity by upregulating thermogenic genes. As phytochemicals have synergistic properties, our research strategy has included investigation of the efficacy of relatively low concentrations of phytochemical blends on BAT activation. Methods: Previously, we showed that R combined with genistein (G) and quercetin (Q) reduced weight gain in aged ovariectomized (OVX) female rats. In the current study, OVX rats were fed diets containing …