Medicine and Health Sciences Commons^™

Peroxisome Proliferator-Activated Receptor Alpha Target Genes, Maryam Rakhshandehroo, Bianca Knoch, Michael Muller, Sander Kersten

Illawarra Health and Medical Research Institute

The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrientmetabolism and energy homeostasis. PPARα serves as amolecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARα binds and is activated by numerous fatty acids and fatty acid-derived compounds. PPARα governs biological processes by altering the expression of a large number of target genes. Accordingly, the specific role of PPARα is directly related to the biological function of its target genes. Here, we present an overview of the involvement …