Medicine and Health Sciences Commons^™

Validation And Evaluation Of The Mandarin Version Of The Oral Health Literacy Adult Questionnaire In Taiwan, Mu-Hsing Ho, Jed Montayre, H.C. Chang, Jee Young Joo, Mohammad Naghibi Sistani, Yen-Kuang Lin, Victoria Traynor, Chia-Chi Chang, Megan F. Liu

Illawarra Health and Medical Research Institute

Objectives

This study aimed to translate the Oral Health Literacy Adult Questionnaire into a Mandarin version (MOHL‐AQ) and to examine its psychometric properties.

Methods

A methodological research using psychometric testing and evaluation of a translated instrument. A convenience sample of 402 participants from northern Taiwan were recruited for the validation of the MOHL‐AQ. Internal consistency reliability, split‐half reliability, inter‐rater reliability, face validity, content validity, and construct validity were evaluated.

Results

The value of internal consistency and split‐half reliability of the MOHL‐AQ were 0.77 and 0.78, respectively. Content validity reported a high content validity index (CVI = 95%). Exploratory factor analysis …

Role Of Area-Level Access To Primary Care On The Geographic Variation Of Cardiometabolic Risk Factor Distribution: A Multilevel Analysis Of The Adult Residents In The Illawarra—Shoalhaven Region Of Nsw, Australia, Renin Melkias Baby Selvi Toms, Xiaoqi Feng, Darren J. Mayne, Andrew D. Bonney

Illawarra Health and Medical Research Institute

Background: Access to primary care is important for the identification, control and management of cardiometabolic risk factors (CMRFs). This study investigated whether differences in geographic access to primary care explained area-level variation in CMRFs. Methods: Multilevel logistic regression models were used to derive the association between area-level access to primary care and seven discrete CMRFs after adjusting for individual and area-level co-variates. Two-step floating catchment area method was used to calculate the geographic access to primary care for the small areas within the study region. Results: Geographic access to primary care was inversely associated with low high density lipoprotein (OR …

Geographic Variation In Cardiometabolic Risk Distribution: A Cross-Sectional Study Of 256,525 Adult Residents In The Illawarra-Shoalhaven Region Of The Nsw, Australia, Renin Toms, Darren J. Mayne, Xiaoqi Feng, Andrew D. Bonney

Illawarra Health and Medical Research Institute

Introduction Metabolic risk factors for cardiovascular disease (CVD) warrant significant public health concern globally. This study aims to utilise the regional database of a major laboratory network to describe the geographic distribution pattern of eight different cardiometabolic risk factors (CMRFs), which in turn can potentially generate hypotheses for future research into locality specific preventive approaches. Method A cross-sectional design utilising de-identified laboratory data on eight CMRFs including fasting blood sugar level (FBSL); glycated haemoglobin (HbA1c); total cholesterol (TC); high density lipoprotein (HDL); albumin creatinine ratio (ACR); estimated glomerular filtration rate (eGFR); body mass index (BMI); and diabetes mellitus (DM) status …

Perinatal Administration Of Phencyclidine Alters Expression Of Lingo-1 Signaling Pathway Proteins In The Prefrontal Cortex Of Juvenile And Adult Rats, Jessica L. Andrews, Kelly A. Newell, Natalie Matosin, Xu-Feng Huang, Francesca Fernandez-Enright

Illawarra Health and Medical Research Institute

Postnatal administration of phencyclidine (PCP) in rodents causes major brain dysfunction leading to severe disturbances in behavior lasting into adulthood. This model is routinely employed to model psychiatric disorders such as schizophrenia, as it reflects schizophrenia related brain disturbances in cluding increased apoptosis, a nd disruptions to myelin and plasticity processes. Leucine -rich repeat and immunoglobulin domain-containing protein, Lingo-1, is a potent negative regulator of both axonal myelination and neurite extension. The Nogo receptor (NgR)/TNF receptor orphan Y (T ROY) and/or p75 complex, With No Lysine (K) (WNK1) and Myelin transcription factor-1 (Myt1) are co-receptors or co-factors in Lingo- 1 …

Intake Of 7,8-Dihydroxyflavone During Juvenile And Adolescent Stages Prevents Onset Of Psychosis In Adult Offspring After Maternal Immune Activation, Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto

Illawarra Health and Medical Research Institute

Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities in their offspring at adulthood. Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC). Furthermore, the adult offspring of poly(I:C)-treated mice showed cognitive deficits, prepulse inhibition (PPI) deficits, reduced BDNF-TrkB signaling, immunoreactivity of parvalbumin (PV) and peroxisome …

Primary Sensory Neuron Addition In The Adult Rat Trigeminal Ganglion: Evidence For Neural Crest Glio-Neuronal Precursor Maturation, Alfonso Lagares, Hong-Yun Li, Xin-Fu Zhou, Carlos Avendano

Illawarra Health and Medical Research Institute

It is debated whether primary sensory neurons of the dorsal root ganglia increase the number in adult animals and, if so, whether the increase is attributable to postnatal neurogenesis or maturation of dormant, postmitotic precursors. Similar studies are lacking in the trigeminal ganglion (TG). Here we demonstrate by stereological methods that the number of neurons in the TG of adult male rats nearly doubles between the third and eighth months of age. The increase is mainly attributable to the addition of small, B-type neurons, with a smaller contribution of large, A-neurons. We looked for possible proliferative or maturation mechanisms that …