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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Primary Sensory Neuron Addition In The Adult Rat Trigeminal Ganglion: Evidence For Neural Crest Glio-Neuronal Precursor Maturation, Alfonso Lagares, Hong-Yun Li, Xin-Fu Zhou, Carlos Avendano
Primary Sensory Neuron Addition In The Adult Rat Trigeminal Ganglion: Evidence For Neural Crest Glio-Neuronal Precursor Maturation, Alfonso Lagares, Hong-Yun Li, Xin-Fu Zhou, Carlos Avendano
Illawarra Health and Medical Research Institute
It is debated whether primary sensory neurons of the dorsal root ganglia increase the number in adult animals and, if so, whether the increase is attributable to postnatal neurogenesis or maturation of dormant, postmitotic precursors. Similar studies are lacking in the trigeminal ganglion (TG). Here we demonstrate by stereological methods that the number of neurons in the TG of adult male rats nearly doubles between the third and eighth months of age. The increase is mainly attributable to the addition of small, B-type neurons, with a smaller contribution of large, A-neurons. We looked for possible proliferative or maturation mechanisms that …
Educational Outcomes Of Children On Guardianship Or Custody Orders: A Pilot Study, Michelle Townsend
Educational Outcomes Of Children On Guardianship Or Custody Orders: A Pilot Study, Michelle Townsend
Illawarra Health and Medical Research Institute
The Australian Institute of Health and Welfare (AIHW) has recently released a report on the educational outcomes for children and young people on guardianship or custody orders. This report, four years in the making, represents one of the first comprehensive Australian assessments based on educational performance data from multiple jurisdictions for children on guardianship or custody orders. Developed for the National Child Protection and Support Services data group, the study was funded by the Community and Disability Services Ministers' Advisory Council (AIHW 2007).
Structure Of Α-Conotoxin Buia: Influences Of Disulfide Connectivity On Structural Dynamics, Ai-Hua Jin, Hemma Brandstaetter, Simon T. Nevin, Chia Chia Tan, Richard J. Clark, David J. Adams, Paul F. Alewood, David J. Craik, Norelle L. Daly
Structure Of Α-Conotoxin Buia: Influences Of Disulfide Connectivity On Structural Dynamics, Ai-Hua Jin, Hemma Brandstaetter, Simon T. Nevin, Chia Chia Tan, Richard J. Clark, David J. Adams, Paul F. Alewood, David J. Craik, Norelle L. Daly
Illawarra Health and Medical Research Institute
Background. α-Conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in α-conotoxins is variable, leading to the classification of sub-families. BuIA is the only α-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin. Results. In the current study we show the native globular disulfide connectivity of BuIA displays multiple conformations in solution whereas the non-native ribbon isomer has a single well-defined conformation. Despite having multiple conformations in solution the globular form of BuIA displays activity at …
Synthesis Of The Oxysterol, 24(S), 25-Epoxycholesterol, Parallels Cholesterol Production And May Protect Against Cellular Accumulation Of Newly-Synthesized Cholesterol, Jenny Wong, Carmel M. Quinn, Andrew J. Brown
Synthesis Of The Oxysterol, 24(S), 25-Epoxycholesterol, Parallels Cholesterol Production And May Protect Against Cellular Accumulation Of Newly-Synthesized Cholesterol, Jenny Wong, Carmel M. Quinn, Andrew J. Brown
Illawarra Health and Medical Research Institute
Aim. The effects of 24(S),25-epoxycholesterol (24,25EC) on aspects of cholesterol homeostasis is well-documented. When added to cells, 24,25EC decreases cholesterol synthesis and up-regulates cholesterol efflux genes, including ABCA1. Synthesis of 24,25EC occurs in a shunt of the mevalonate pathway which also produces cholesterol. Therefore, 24,25EC synthesis should be subject to the same negative feedback regulation as cholesterol synthesis. To date, no role has been ascribed to 24,25EC in light of the fact that increased accumulation of cholesterol should decrease formation of this oxysterol through feedback inhibition. This leads to the intriguing paradox: why inhibit production of an apparently important regulator …