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Full-Text Articles in Medicine and Health Sciences
Cryptosporidiosis In An Alpaca Cria Secondary To Prolongedantimicrobial Administration, Heidi M. Wyrosdick, Caroline Griffin, John J. Schaefer, Joseph Smith
Cryptosporidiosis In An Alpaca Cria Secondary To Prolongedantimicrobial Administration, Heidi M. Wyrosdick, Caroline Griffin, John J. Schaefer, Joseph Smith
Faculty Publications and Other Works -- Large Animal Clinical Sciences
No abstract provided.
Delayed Urethral Obstruction After Migration Of A Ballistic Pellet In An Alpine Wether, Joseph Smith
Delayed Urethral Obstruction After Migration Of A Ballistic Pellet In An Alpine Wether, Joseph Smith
Faculty Publications and Other Works -- Large Animal Clinical Sciences
A one-year-old alpine wether was presented for emergency evaluation of stranguria. Diagnostics identified a moderately distended bladder and mild dehydration. Preliminary lateral radiographs identified two metallic structures consistent with projectile pellets in the pelvic and perineal regions and no evidence of radiopaque uroliths. A tube cystostomy was performed, and a contrast urethrogram revealed one of the pellets in the perineal region was in proximity to the urethral obstruction. Subsequent radiography and ultrasound identified the pellet as being within the lumen of the urethra. Examination of the trichotomized skin revealed two scars, including a scar over the paralumbar fossa in the …
The Pharmacokinetics And Pharmacodynamics Of Esomeprazole In Sheep After Intravenous Dosing, Joseph Smith, Jessica Gebert, Kailee Bennett, Lisa Sams Ebner, Ryan Flynn, Pierre-Yves Mulon, Lainey Harvill, Olivia Escher, Amanda Jo Kreuder, Joan Bergman, Sherry Cox
The Pharmacokinetics And Pharmacodynamics Of Esomeprazole In Sheep After Intravenous Dosing, Joseph Smith, Jessica Gebert, Kailee Bennett, Lisa Sams Ebner, Ryan Flynn, Pierre-Yves Mulon, Lainey Harvill, Olivia Escher, Amanda Jo Kreuder, Joan Bergman, Sherry Cox
Faculty Publications and Other Works -- Large Animal Clinical Sciences
Abomasal (gastric) ulceration is a morbidity in sheep, and currently, there is a paucity of pharmacokinetic and pharmacodynamic data for gastroprotectant drugs reported for this species. The proton pump inhibitor esomeprazole has been used in small animal and human patients for gastroprotection via increasing the gastric pH. The objective of this study was to report the pharmacokinetic parameters and pharmacodynamic effect of esomeprazole in sheep after single intravenous dosing. Four healthy adult Southdown cross ewes had blood collected over a 24 h time period after single intravenous dosing of esomeprazole at 1.0 mg/kg. Abomasal fluid was sampled over 24 h …
Pharmacokinetics Of Intramuscular Maropitant In Pigs (Sus Scrofa Domesticus), Joseph Smith, Jessica E. Gebert, Lisa S. Ebner, Kailee O. Bennett, Rebecca J. Collins, Chiara E. Hampton, Stephanie A. Kleine, Pierre-Yves Mulon, Christopher K. Smith, Reza Seddighi, Genevieve Bussieres, Jonathan P. Mochel, Healther K. Knych
Pharmacokinetics Of Intramuscular Maropitant In Pigs (Sus Scrofa Domesticus), Joseph Smith, Jessica E. Gebert, Lisa S. Ebner, Kailee O. Bennett, Rebecca J. Collins, Chiara E. Hampton, Stephanie A. Kleine, Pierre-Yves Mulon, Christopher K. Smith, Reza Seddighi, Genevieve Bussieres, Jonathan P. Mochel, Healther K. Knych
Faculty Publications and Other Works -- Large Animal Clinical Sciences
Pigs are at risk of vomiting from medical conditions as well as the emetic side effects of drugs administered for peri-operative manipulations, but there is a lack of pharmacokinetic data for potential anti-emetic therapies, such as maropitant, in this species. The main objective of this study was to estimate plasma pharmacokinetic parameters for maropitant in pigs after a single intramuscular (IM) administration dosed at 1.0 mg/ kg. A secondary objective was to estimate pilot pharmacokinetic parameters in pigs after oral (PO) administration at 2.0 mg/kg. Maropitant was administered to six commercial pigs at a dose of 1.0 mg/kg IM. Plasma …