Medicine and Health Sciences Commons^™

Pharmacokinetics Of Esomeprazole In Goats (Capra Aegagrus Hircus) After Intravenous And Subcutaneous Administration, Rachel L. Fladung, Joseph Smith, Melissa Hines, Windy Soto-Gonzalez, Bryanna Fayne, Rebecca Rahn, Olivia Escher, Lainey Harvill, Joan Bergman, Jessica Garcia, Amanda Kreuder

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Background: Stressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.

Objectives: The objectives for this study were to estimate plasma pharmacokinetic parameters for esomeprazole in adult goats after intravenous (IV) and subcutaneous (SQ) administration. A secondary objective was to describe the plasma kinetics of the metabolite esomeprazole sulfone after IV and SC administration in goats.

Materials and methods: Esomeprazole was administered to 5 adult goats in a crossover study at doses of 1 mg/kg IV or 2 mg/kg SC. …

Validation Of A Method For Pantoprazole And Its Sulfone Metabolite In Goat Plasma Using High Performance Liquid Chromatography, Sherry Cox, Lainey Harvill, Sarah Bullock, Joseph Smith, Joan Bergman

Faculty Publications and Other Works -- Large Animal Clinical Sciences

No abstract provided.

Pharmacokinetics Of Butorphanol Following Intravenous And Intramuscular Administration In Donkeys: A Preliminary Study, Lisa S. Ebner, Odette O, Bradley Simon, Ignacio Lizarraga, Joseph Smith, Sherry Cox

Faculty Publications and Other Works -- Large Animal Clinical Sciences

The pharmacokinetics of butorphanol after intravenous (IVB) and intramuscular (IMB) administration in donkeys were determined in this preliminary study. Healthy male gelded donkeys (n = 5), aged 6–12 years old, were administered 0.1 mg/kg butorphanol IV or IM in a randomized, crossover design. Blood samples were obtained at predetermined intervals for 24 h (IVB) and 48 h (IMB) after administration. Plasma butorphanol concentrations were determined by high performance liquid chromatography and pharmacokinetic parameters were calculated. Following IVB administration, mean (± SE) apparent volume of distribution, elimination half-life, total body clearance, and area under the plasma concentration time curve from …

Failure Of Passive Transfer In Camel Calves: 4 Cases (2010-2019), Amanda James, Joseph Smith, Julie Sheldon, Ricardo Videla

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Failure of passive transfer is a management concern for all ruminant species, but is not well described in the literature for camel calves. This case series presents four camel calves (Camelus dromedarius and Camelus bactrianus) referred to a North American veterinary teaching hospital for diagnosis and management of failure of passive transfer. Diagnostics utilized included hematology, serum biochemistry, and immunologic methods as described for crias. Management included antimicrobial, anti-inflammatory, and plasma transfusion therapies. Three of the four calves survived to discharge, and common diagnostic practices such as evaluation of total solids, total protein, immunoglobulin G, and sodium sulfite appear to …

Miniature Companion Pig Sedation And Anesthesia, Joseph Smith, Reza Seddighi

Faculty Publications and Other Works -- Large Animal Clinical Sciences

• Miniature companion pigs (MCP) are increasing in popularity, and as such, there is an increased need for veterinarians trained in sedation and anesthesia for the species.

• MCPs have several species-specific qualities that can complicate injectable drug administration and create challenges for inhalational anesthesia (eg, with endotracheal intubation).

• General anesthetic complications, such as hypothermia and hypotension, are commonly described in miniature companion pigs, so monitoring of vital parameters during anesthetic procedures and recovery is crucial.

Severe Mandibular Osteomyelitis And Exfoliation Of A Mandibular Canine Tooth In A Vietnamese Potbellied Pig, Joseph Smith, Caroline Griffin, Phil Jones, Brenda Mulherin, Silke Hecht

Faculty Publications and Other Works -- Large Animal Clinical Sciences

∙Preventative care of miniature companion pigs should include regular oral examinations and incorporate routine tusk maintenance.

∙Severe dental disease can lead to significant sequelae, including osteomyelitis leading to loss of mandibular structural integrity.

∙Diagnostic imaging is a useful tool for assessment of dental disease in miniature companion pigs.

A Chronic, Non-Healing, Ulcerative And Proliferative Lesion Revealed To Be Squamous Cell Carcinoma In A Camel, Jessica Garcia, Elizabeth Molinet, Camille Marie Cordero Aponte, Ariel Carlson, Pierre-Yves Mulon

Faculty Publications and Other Works -- Large Animal Clinical Sciences

A 20-year-old, male, neutered camel presented with an 8-month history of a proliferative and ulcerated cush pad lesion refractory to topical wound management. The referring veterinarian performed a punch biopsy to further investigate the tissue; findings were consistent with granulation tissue. The patient was referred to University of Tennessee Farm Animal Medicine and Surgery service for additional diagnostics, surgical debridement and intensive wound care. The camel underwent surgical debridement of the lesion, and histopathology was consistent with a squamous cell carcinoma. Bloodwork revealed a severe non-regenerative anaemia and leukocytosis suspected to be paraneoplastic changes. During hospitalisation, it was identified that …