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Flexible Nets: Disorder And Induced Fit In The Associations Of P53 And 14-3-3 With Their Partners, Christopher J. Oldfield, Jingwei Meng, Jack Y. Yang, Mary Qu Yang, Vladimir N. Uversky, A. Keith Dunker
Flexible Nets: Disorder And Induced Fit In The Associations Of P53 And 14-3-3 With Their Partners, Christopher J. Oldfield, Jingwei Meng, Jack Y. Yang, Mary Qu Yang, Vladimir N. Uversky, A. Keith Dunker
Molecular Medicine Faculty Publications
Background: Proteins are involved in many interactions with other proteins leading to networks that regulate and control a wide variety of physiological processes. Some of these proteins, called hub proteins or hubs, bind to many different protein partners. Protein intrinsic disorder, via diversity arising from structural plasticity or flexibility, provide a means for hubs to associate with many partners (Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN: Flexible Nets: The roles of intrinsic disorder in protein interaction networks. FEBS J 2005, 272:5129-5148).
Results: Here we present a detailed examination of two divergent examples: 1) p53, which uses different …