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Differential Expression Of Homing-Associated Cell Adhesion Molecule, Very Late Antigen-4 And L-Selectin In Hematopoietic Progenitor Cell Trafficking Between The Marrow And Blood, Caroline Brigitte Fultz
Differential Expression Of Homing-Associated Cell Adhesion Molecule, Very Late Antigen-4 And L-Selectin In Hematopoietic Progenitor Cell Trafficking Between The Marrow And Blood, Caroline Brigitte Fultz
USF Tampa Graduate Theses and Dissertations
This study addresses the hypothesis that the following cell adhesion molecules (CAMs): homing-associated cell adhesion molecule (HCAM), very late antigen-4 (VLA-4) and L-selectin play a role in the trafficking of hematopoietic progenitor cells (HPCs) between the bone marrow microenvironment and the peripheral circulation. In order to ascertain differences in CAM expression based on physiologic compartment, the expression of HCAM, VLA-4 or L-selectin per CD34+ myeloid progenitor cell was assessed between paired samples of blood and marrow. CAM expression was flow cytometrically quantitated in paired samples obtained from patients treated with mobilizing doses of granulocyte-colony stimulating factor (G-CSF) or from …