Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Deciphering The Dark Proteome Of Chikungunya Virus, Ankur Singh, Ankur Kumar, Rakhi Yadav, Vladimir N. Uversky, Rajanish Giri
Deciphering The Dark Proteome Of Chikungunya Virus, Ankur Singh, Ankur Kumar, Rakhi Yadav, Vladimir N. Uversky, Rajanish Giri
Molecular Medicine Faculty Publications
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV infection has been seen in many tropical and subtropical regions of the biosphere. Current reports evidenced that after outbreaks in 2005–06, the fitness of this virus propagating in Aedes albopictus enhanced due to the epistatic mutational changes in its envelope protein. In our study, we evaluated the prevalence of intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) in CHIKV proteome. IDPs/IDPRs are known as members of a ‘Dark Proteome’ that defined as a set of polypeptide segments or whole protein without unique three-dimensional structure within the cellular milieu but …
Intrinsic Disorder And Posttranslational Modifications: The Darker Side Of The Biological Dark Matter, April L. Darling, Vladimir N. Uversky
Intrinsic Disorder And Posttranslational Modifications: The Darker Side Of The Biological Dark Matter, April L. Darling, Vladimir N. Uversky
Molecular Medicine Faculty Publications
Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are functional proteins and domains that devoid stable secondary and/or tertiary structure. IDPs/IDPRs are abundantly present in various proteomes, where they are involved in regulation, signaling, and control, thereby serving as crucial regulators of various cellular processes. Various mechanisms are utilized to tightly regulate and modulate biological functions, structural properties, cellular levels, and localization of these important controllers. Among these regulatory mechanisms are precisely controlled degradation and different posttranslational modifications (PTMs). Many normal cellular processes are associated with the presence of the right amounts of precisely activated IDPs at right …