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Full-Text Articles in Medicine and Health Sciences
Characteristics And Predictors Of Fatigue Among Men Receiving Androgen Deprivation Therapy For Prostate Cancer: A Controlled Comparison, Ashley M. Nelson, Brian D. Gonzalez, Heather S.L. Jim, Julie M. Cessna, Steven K. Sutton, Brent J. Small, Mayer N. Fishman, Babu Zachariah, Paul B. Jacobsen
Characteristics And Predictors Of Fatigue Among Men Receiving Androgen Deprivation Therapy For Prostate Cancer: A Controlled Comparison, Ashley M. Nelson, Brian D. Gonzalez, Heather S.L. Jim, Julie M. Cessna, Steven K. Sutton, Brent J. Small, Mayer N. Fishman, Babu Zachariah, Paul B. Jacobsen
Aging Studies Faculty Publications
Purpose: Although fatigue is a common problem for men with prostate cancer undergoing androgen deprivation therapy (ADT), there has been little systematic research on this issue. The present study examined changes in fatigue among prostate cancer patients receiving ADT compared to controls and predictors of heightened fatigue in ADT patients.
Methods: Prostate cancer patients treated with ADT (ADT+ group, n = 60) completed assessments of fatigue prior to or just after ADT initiation (baseline) and 6 and 12 months later. Prostate cancer patients treated with prostatectomy only (ADT- group, n = 85) and men without cancer (CA- group, n = …
Changes In Physical Functioning And Muscle Strength In Men Receiving Androgen Deprivation Therapy For Prostate Cancer: A Controlled Comparison, Brian D. Gonzalex, Heather S. L. Jim, Brent J. Small, Mayer N. Fishman, Babu Zachariah, Randy V. Heysek, Paul B. Jacobsen
Changes In Physical Functioning And Muscle Strength In Men Receiving Androgen Deprivation Therapy For Prostate Cancer: A Controlled Comparison, Brian D. Gonzalex, Heather S. L. Jim, Brent J. Small, Mayer N. Fishman, Babu Zachariah, Randy V. Heysek, Paul B. Jacobsen
Aging Studies Faculty Publications
Purpose: The purpose of the study is to examine changes in muscle strength and self-reported physical functioning in men receiving androgen deprivation therapy (ADT) for prostate cancer compared to matched controls.
Methods: Prostate cancer patients scheduled to begin ADT (n = 62) were assessed within 20 days of starting ADT and 6 and 12 months later. Age and geographically matched prostate cancer controls treated with prostatectomy only (n = 86) were assessed at similar time intervals. Grip strength measured upper body strength, the Chair Rise Test measured lower body strength, and the SF-12 Physical Functioning scale measured self-reported physical functioning. …
Apolipoprotein E And Clusterin Can Magnify Effects Of Personality Vulnerability On Declarative Memory Performance In Non‐Demented Older Adults, Sharaddha Sapkota, Sandra A. Wiebe, Brent J. Small, Roger A. Dixon
Apolipoprotein E And Clusterin Can Magnify Effects Of Personality Vulnerability On Declarative Memory Performance In Non‐Demented Older Adults, Sharaddha Sapkota, Sandra A. Wiebe, Brent J. Small, Roger A. Dixon
Aging Studies Faculty Publications
Objectives: Recent research has linked psychological (personality) factors and specific genetic risk polymorphisms to performance on neurocognitive phenotypes. We examined whether episodic or semantic memory performance is associated with (a) three personality traits (i.e. neuroticism, extraversion, and openness to experience), (b) two neurodegenerative‐related polymorphisms (i.e. Apolipoprotein E (APOE; rs7412; rs429358), Clusterin (CLU; rs11136000)), and (c) cross‐domain risk interactions (magnification effects).
Methods: Linear growth models were examined to test independent associations between personality traits and declarative memory performance, and potential interaction effects with APOE and CLU genetic risk. Normal older adults (n = 282) with personality …
Comt And Oprm1 Genotype Associations With Daily Knee Pain Variability And Activity Induced Pain, Lynn M. Martire, Stephanie J. Wilson, Brent J. Small, Yvette P. Conley, Piotr K. Janicki, Martin J. Sliwinski
Comt And Oprm1 Genotype Associations With Daily Knee Pain Variability And Activity Induced Pain, Lynn M. Martire, Stephanie J. Wilson, Brent J. Small, Yvette P. Conley, Piotr K. Janicki, Martin J. Sliwinski
Aging Studies Faculty Publications
Background: Osteoarthritis (OA) of the knee is a common and increasingly prevalent condition that is one of the primary causes of chronic pain. Staying physically active protects against disability from knee OA but is also very challenging. A critical but unexamined question is whether patients at greatest risk for becoming less active are those with a genetic predisposition for greater sensitivity to daily pain.
Aims: We examined day-to-day variability in knee OA pain for patients with different variants of catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) single nucleotide polymorphisms (SNPs), and whether patients with a specific genotype experience more pain following …