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Full-Text Articles in Medicine and Health Sciences
Discharge And Role Of Acetylcholine Pontomesencephalic Neurons In Cortical Activity And Sleep-Wake States Examined By Optogenetics And Juxtacellular Recording In Mice, Youssouf Cisse, Hanieh Toossi, Masaru Ishibashi, Lynda Mainville, Christopher S. Leonard, Antoine Adamantidis, Barbara E. Jones
Discharge And Role Of Acetylcholine Pontomesencephalic Neurons In Cortical Activity And Sleep-Wake States Examined By Optogenetics And Juxtacellular Recording In Mice, Youssouf Cisse, Hanieh Toossi, Masaru Ishibashi, Lynda Mainville, Christopher S. Leonard, Antoine Adamantidis, Barbara E. Jones
NYMC Faculty Publications
Acetylcholine (ACh) neurons in the pontomesencephalic tegmentum (PMT) are thought to play an important role in promoting cortical activation with waking (W) and paradoxical sleep [PS; or rapid eye movement (REM)], but have yet to be proven to do so by selective stimulation and simultaneous recording of identified ACh neurons. Here, we employed optogenetics combined with juxtacellular recording and labeling of neurons in transgenic (TG) mice expressing ChR2 in choline acetyltransferase (ChAT)-synthesizing neurons. We established in vitro then in vivo in anesthetized (A) and unanesthetized (UA), head-fixed mice that photostimulation elicited a spike with short latency in neurons which could …
Respiratory Syncytial Virus Hospitalization Risk In The Second Year Of Life By Specific Congenital Heart Disease Diagnoses, Deborah Friedman, J Fryzek, X Jiang, A Bloomfield, C Ambrose, P Wong
Respiratory Syncytial Virus Hospitalization Risk In The Second Year Of Life By Specific Congenital Heart Disease Diagnoses, Deborah Friedman, J Fryzek, X Jiang, A Bloomfield, C Ambrose, P Wong
NYMC Faculty Publications
Children with hemodynamically significant congenital heart disease (CHD) are at elevated risk of morbidity and mortality due to respiratory syncytial virus (RSV) disease compared to their healthy peers. Previous studies have demonstrated lower RSV hospitalization risk among all children with CHD at 12-23 months of age versus 0-11 months of age. However, RSV hospitalization risk at 12-23 months of age by specific CHD diagnosis has not been characterized. Both case-control and cohort studies were conducted using data from the US National Inpatient Sample from 1997 to 2013 to characterize relative risk of RSV hospitalization among children 12-23 months of age …