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Full-Text Articles in Medicine and Health Sciences
Biological Variability Dominates And Influences Analytical Variance In Hplc-Ecd Studies Of The Human Plasma Metabolome, Yevgeniya I. Shurubor, Wayne R. Matson, Walter C. Willett, Susan E. Hankinson, Bruce S. Kristal
Biological Variability Dominates And Influences Analytical Variance In Hplc-Ecd Studies Of The Human Plasma Metabolome, Yevgeniya I. Shurubor, Wayne R. Matson, Walter C. Willett, Susan E. Hankinson, Bruce S. Kristal
Susan E. Hankinson
Background Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations coupled with coulometric array detection that can accurately identify ad libitum fed and caloric-restricted rats. These profiles are being adapted for human epidemiology studies, given the importance of energy balance in human disease. Methods Human plasma samples were biochemically analyzed using HPLC separations coupled with coulometric electrode array detection. Results We identified these markers/metabolites in human plasma, and then used them to determine which human samples represent blinded duplicates with 100% accuracy (N = 30 of 30). …
Tgfb1 And Tgfbr1 Polymorphisms And Breast Cancer Risk In The Nurses' Health Study, David G. Cox, Kathryn Penney, Qun Guo, Susan E. Hankinson, David J. Hunter
Tgfb1 And Tgfbr1 Polymorphisms And Breast Cancer Risk In The Nurses' Health Study, David G. Cox, Kathryn Penney, Qun Guo, Susan E. Hankinson, David J. Hunter
Susan E. Hankinson
Background Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results. Methods We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort. Results No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse …
Common Genetic Variation In Igf1, Igfbp-1, And Igfbp-3 In Relation To Mammographic Density: A Cross-Sectional Study, Rulla M. Tamimi, David G. Cox, Peter Kraft, Michael N. Pollak, Christopher A. Haiman, Iona Cheng, Matthew L. Freedman, Susan E. Hankinson, David J. Hunter, Graham A. V. Colditz
Common Genetic Variation In Igf1, Igfbp-1, And Igfbp-3 In Relation To Mammographic Density: A Cross-Sectional Study, Rulla M. Tamimi, David G. Cox, Peter Kraft, Michael N. Pollak, Christopher A. Haiman, Iona Cheng, Matthew L. Freedman, Susan E. Hankinson, David J. Hunter, Graham A. V. Colditz
Susan E. Hankinson
Introduction Mammographic density is one of the strongest risk factors for breast cancer and is believed to represent epithelial and stromal proliferation. Because of the high heritability of breast density, and the role of the insulin-like growth factor (IGF) pathway in cellular proliferation and breast development, we examined the association between common genetic variation in this pathway and mammographic density. Methods We conducted a cross-sectional analysis among controls (n = 1,121) who were between the ages of 42 and 78 years at mammography, from a breast cancer case-control study nested within the Nurses' Health Study cohort. At the time of …
A Polymorphism In The 3' Untranslated Region Of The Gene Encoding Prostaglandin Endoperoxide Synthase 2 Is Not Associated With An Increase In Breast Cancer Risk: A Nested Case-Control Study, David G. Cox, Julie Buring, Susan E. Hankinson, David J. Hunter
A Polymorphism In The 3' Untranslated Region Of The Gene Encoding Prostaglandin Endoperoxide Synthase 2 Is Not Associated With An Increase In Breast Cancer Risk: A Nested Case-Control Study, David G. Cox, Julie Buring, Susan E. Hankinson, David J. Hunter
Susan E. Hankinson
Introduction Prostaglandins are integral components in the cellular response to inflammation, promoting cellular proliferation and angiogenesis. The enzyme responsible for the conversion of arachidonic acid to prostaglandins in response to inflammation is prostaglandin endoperoxide synthase 2/cyclo-oxygenase 2 (PTGS2/COX2). Polymorphisms in the PTGS2 gene have been associated with various diseases, including inflammatory bowel disease and cancer of the lung, colorectum, and breast. Methods We genotyped the five most common polymorphisms (rs20417, rs5277, rs20432, rs5275, and rs4648298) in the Nurses' Health Study (1,270 cases, 1,762 controls) to test the hypothesis that polymorphisms in PTGS2 are associated with breast cancer risk, using logistic …