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Exposure To Cerium Oxide Nanoparticles Is Associated With Activation Of Mitogen-Activated Protein Kinases Signaling And Apoptosis In Rat Lungs, Kevin M. Rice, Siva K. Nalabotu, Nandini D.P.K. Manne, Madhukar B. Kolli, Geeta Nandyala, Ravi K. Arvapalli, Jane Y. Ma, Eric R. Blough
Exposure To Cerium Oxide Nanoparticles Is Associated With Activation Of Mitogen-Activated Protein Kinases Signaling And Apoptosis In Rat Lungs, Kevin M. Rice, Siva K. Nalabotu, Nandini D.P.K. Manne, Madhukar B. Kolli, Geeta Nandyala, Ravi K. Arvapalli, Jane Y. Ma, Eric R. Blough
Ravi K. Arvapalli
Objectives: With recent advances in nanoparticle manufacturing and applications, potential exposure to nanoparticles in various settings is becoming increasing likely. No investigation has yet been performed to assess whether respiratory tract exposure to cerium oxide (CeO2) nanoparticles is associated with alterations in protein signaling, inflammation, and apoptosis in rat lungs.
Methods: Specific-pathogen-free male Sprague-Dawley rats were instilled with either vehicle (saline) or CeO2 nanoparticles at a dosage of 7.0 mg/kg and euthanized 1, 3, 14, 28, 56, or 90 days after exposure. Lung tissues were collected and evaluated for the expression of proteins associated with inflammation and cellular …