Medicine and Health Sciences Commons^™

Carbosilane Dendrimers: Drug And Gene Delivery Applications, Navid Rabiee, Shokooh Ahmadvand, Sepideh Ahmadi, Yousef Fatahi, Rassoul Dinarvand, Mojtaba Bagherzadeh, Mohammad Rabiee, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Carbosilane dendrimers are a particular type of dendrimer structure that has been used as delivery vehicles for drugs and nucleic acids. They have a defined structure according to their generation number, and their terminal groups can be rendered cationic or anionic. The cationic charges can address the limitation of electrostatic repulsion between the negatively charged phosphate groups of nucleic acids and negatively charged cell membranes. Specific drugs can be loaded into the central part of the dendrimer or attached at the exterior, and the overall positive charge may improve the efficacy of anti-inflammatory drugs. One promising feature of dendrimers is …

Recent Advances In Designing 5-Fluorouracil Delivery Systems: A Stepping Stone In The Safe Treatment Of Colorectal Cancer, Elaheh Entezar-Almahdi, Soliman Mohammadi-Samani, Lobat Tayebi, Fatemeh Farjadian

School of Dentistry Faculty Research and Publications

5-Fluorouracil (5-FU) has become one of the most widely employed antimetabolite chemotherapeutic agents in recent decades. It is considered a first line antineoplastic agent for the treatment of colorectal cancer. Unfortunately, chemotherapy with 5-FU has several limitations, including its short half-life, high cytotoxicity and low bioavailability. In order to overcome the drawbacks of 5-FU and enhance its therapeutic efficiency, many scientific groups have focused on designing a new delivery system to successfully deliver 5-FU to tumor sites. We provide a comprehensive review on different strategies to design effective delivery systems, including nanoformulations, drug-conjugate formulations and other strategies for the delivery …

Burgeoning Polymer Nano Blends For Improved Controlled Drug Release: A Review, Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Yousef Fatahi, Rassoul Dinarvand, Maryam Tavakolizadeh, Sepideh Ahmadi, Mohammad Rabiee, Mojtaba Bagherzadeh, Ali Pourjavadi, Hassan Farhadnejad, Mohammadreza Tahriri, Thomas J. Webster, Lobat Tayebi

School of Dentistry Faculty Research and Publications

With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds …

Recent Advances In Porphyrin-Based Nanocomposites For Effective Targeted Imaging And Therapy, Navid Rabiee, Mohammad Tavakkoli Yaraki, Soha Mokhtari Garakani, Shima Mokhtari Garakani, Sepideh Ahmadi, Aseman Lajevardi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the “pigments of life”. They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have …

Temperature And Ph-Responsive Nano-Hydrogel Drug Delivery System Based On Lysine-Modified Poly (Vinylcaprolactam), Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E. Welland, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Background: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating factors in designing systems for anti-cancer drugs delivery systems.

Purpose: In this study, thermo and pH-responsive character of a nano-carrier drug delivery platform based on lysine modified poly (vinylcaprolactam) hydrogel conjugated with doxorubicin was assessed.

Methods: Poly (vinylcaprolactam) cross-linked with poly (ethyleneglycol) diacrylate was prepared via RAFT polymerization, and the prepared structure was linked with lysine through ring-opening. The anti-cancer drug doxorubicin, was linked to lysine moiety …

Nanomagnetic-Mediated Drug Delivery For The Treatment Of Dental Disease, Yadong Ji, Seung K. Choi, Ahmed S. Sultan, Kong Chuncai, Xiaoying Lin, Erfan Dashtimoghadam, Mary Anne Melo, Michael Weir, Huakun Xu, Lobat Tayebi, Ahihong Nie, Didier A. Depireux, Radi Masri

School of Dentistry Faculty Research and Publications

Maintaining the vitality of the dental pulp, the highly innervated and highly vascular, innermost layer of the tooth, is a critical goal of any dental procedure. Upon injury, targeting the pulp with specific therapies is challenging because it is encased in hard tissues. This project describes a method that can effectively deliver therapeutic agents to the pulp. This method relies on the use of nanoparticles that can be actively steered using magnetic forces to the pulp, traveling through naturally occurring channels in the dentin (the middle layer of the tooth). This method can reduce the inflammation of injured pulp and …