Medicine and Health Sciences Commons^™

Biomaterials In Valvular Heart Diseases, Bita Taghizadeh, Laleh Ghavami, Hossein Derakhshankhah, Ehsan Zangene, Mahdieh Razmi, Mehdi Jaymand, Payam Zarrintaj, Nosratollah Zarghami, Mahmoud Reza Jaafari, Matin Moallem Shahri, Adrineh Moghaddasian, Lobat Tayebi, Zhila Izadi

School of Dentistry Faculty Research and Publications

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient's quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach …

Efficacy Of The Biomaterials 3 Wt%-Nanostrontium-Hydroxyapatite-Enhanced Calcium Phosphate Cement (Nanosr-Cpc) And Nanosr-Cpc-Incorporated Simvastatin-Loaded Poly(Lactic-Co-Glycolic-Acid) Microspheres In Osteogenesis Improvement, Reza Masaeli, Tahereh S. Jafarzadeh Kashi, Rassoul Dinarvand, Vahid Rakhshan, Hossein Shahoon, Behzad Hooshmand, Fatemeh Mashhadi Abbas, Majid Raz, Alireza Rajabnejad, Hossein Eslami, Kimia Khoshroo, Mohammadreza Tahriri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Aims

The purpose of this multi-phase explorative in vivo animal/surgical and in vitro multi-test experimental study was to (1) create a 3 wt%-nanostrontium hydroxyapatite-enhanced calcium phosphate cement (Sr-HA/CPC) for increasing bone formation and (2) creating a simvastatin-loaded poly(lactic-co-glycolic acid) (SIM-loaded PLGA) microspheres plus CPC composite (SIM-loaded PLGA + nanostrontium-CPC). The third goal was the extensive assessment of multiple in vitro and in vivo characteristics of the above experimental explorative products in vitro and in vivo (animal and surgical studies).

Methods and results pertaining to Sr-HA/CPC

Physical and chemical properties of the prepared Sr-HA/CPC were evaluated. MTT assay and …

Three-Dimensional Bioprinting Materials With Potential Application In Preprosthetic Surgery, Mina D. Fahmy, Hossein E. Jazayeri, Mehdi Razavi, Radi Masri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon’s skills and the inherent potential in the patients’ bodies for regenerating lost tissues. Employing custom-designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists. These scaffolds not only are beneficial due to their patient-specific design, but …

Transdermal Delivery Of Functional Collagen Via Polyvinylpyrrolidone Microneedles, Wenchao Sun, Mohammed Inayathullah, Martin A. C. Manoukian, Andrey V. Malkovskiy, Sathish Manickam, M. Peter Marinkovich, Alfred T. Lane, Lobat Tayebi, Alexander M. Seifalian, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities. This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system. The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w/w). Microneedle structures and the distribution of collagen were characterized using scanning electron microscopy and confocal microscopy. Patches were then applied on the porcine and human skin, and their effectiveness was examined using fluorescence …

Histological And Immunohistochemical Evaluation Of Biphasic Calcium Phosphate And A Mineral Trioxide Aggregate For Bone Healing In Rat Calvaria, Luis Gustavo Régio De Carvalho Silva, Sung Hyun Kim, Sônia Mara Luczyszyn, Allan Giovanini, Luis Eduardo Almeida, Vinícius Augusto Tramontina

School of Dentistry Faculty Research and Publications

This work focused on the process of bone repair of defects in standardized calvaria of Wistar rats treated with biphasic calcium phosphate (BCP), mineral trioxide aggregate (MTA), or a combination of the two. Eighty Wistar rats were divided into four treatment groups and were examined at 2 and 8 weeks. A surgical defect was created in the calvaria using a 6-mm diameter trephine drill. The cavity was treated with BCP, MTA, or BCP + MTA; untreated rats with clot formation served as controls. Samples were evaluated histologically and by immunohistochemical staining for areas of new osteoid tissue and new bone …

Surface Modification Of Biodegradable Porous Mg Bone Scaffold Using Polycaprolactone/Bioactive Glass Composite, Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dip-coating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable …

Management Of Crown-Related Fractures In Children: An Update Review, H. Cem Güngör

School of Dentistry Faculty Research and Publications

Traumatic dental injuries (TDIs) are a serious public health problem. Epidemiology of dental trauma indicates that these injuries are more prevalent in child population of the world. Children are the sufferers in two-thirds of all TDIs observed. Although being a major fraction, crown-related fractures are a less severe form of TDIs with respect to their complications and sequelae. However, as with other types of traumatic injuries, the delay in seeking for immediate care following a traumatic injury and the lack of appropriate treatment may compromise long-term outcomes. This article reviews the occurrence, management, and prognosis of crown-related fractures in primary …