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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Protection Of Retinal Cells From Ischemia By A Novel Gap Junction Inhibitor, Satyabrata Das, Dingo Lin, Snehalata Jena, Aibin Shi, Srinivas Battina, Duy H. Hua, Rachel A. Allbaugh, Dolores J. Takemoto
Protection Of Retinal Cells From Ischemia By A Novel Gap Junction Inhibitor, Satyabrata Das, Dingo Lin, Snehalata Jena, Aibin Shi, Srinivas Battina, Duy H. Hua, Rachel A. Allbaugh, Dolores J. Takemoto
Rachel A. Allbaugh
Retinal cells which become ischemic will pass apoptotic signal to adjacent cells, resulting in the spread of damage. This occurs through open gap junctions. A class of novel drugs, based on primaquine (PQ), was tested for binding to connexin 43 using simulated docking studies. A novel drug has been synthesized and tested for inhibition of gap junction activity using R28 neuro-retinal cells in culture. Four drugs were initially compared to mefloquine, a known gap junction inhibitor. The drug with optimal inhibitory activity, PQ1, was tested for inhibition and was found to inhibit dye transfer by 70% at 10 μM. Retinal …
Plan Your Future With Advance Directives Poster, Debra M. Sellers
Plan Your Future With Advance Directives Poster, Debra M. Sellers
Debra M. Sellers
Poster, three pages that define Living Will, Durable Power of Attorney for Health Care.
Assistive Technology Postcard, Debra M. Sellers, Erin J. Dittman
Assistive Technology Postcard, Debra M. Sellers, Erin J. Dittman
Debra M. Sellers
Postcard on assistive technology, tools to help make life easier, for people with arthritis, disabilities, etc.
Fashion An Easier Lifestyle With Assistive Technology: Leader's Guide, Debra M. Sellers, Erin J. Dittman
Fashion An Easier Lifestyle With Assistive Technology: Leader's Guide, Debra M. Sellers, Erin J. Dittman
Debra M. Sellers
Assistive technology is about tools to help make life easier, for people with arthritis, disabilities, etc. It helps with meals, housework, personal care, and other activities.
Fashion An Easier Lifestyle With Assistive Technology: Fact Sheet, Debra M. Sellers, Erin J. Dittman
Fashion An Easier Lifestyle With Assistive Technology: Fact Sheet, Debra M. Sellers, Erin J. Dittman
Debra M. Sellers
Assistive technology is about tools to help make life easier, for people with arthritis, disabilities, etc. It helps with meals, housework, personal care, and other activities.
In Vivo Ultrasonic Attenuation Slope Estimates For Detecting Cervical Ripening In Rats: Preliminary Results, Timothy A. Bigelow, Barbara L. Mcfarlin, William D. O'Brien Jr., Michael L. Oelze
In Vivo Ultrasonic Attenuation Slope Estimates For Detecting Cervical Ripening In Rats: Preliminary Results, Timothy A. Bigelow, Barbara L. Mcfarlin, William D. O'Brien Jr., Michael L. Oelze
Timothy A. Bigelow
To effectively postpone preterm birth, cervical ripening needs to be detected and delayed. As the cervix ripens, the spacing between the collagen fibers increases and fills with water, hyaluronan, decorin, and enzymes suggesting that the ultrasonic attenuation of the cervix should decrease. The decrease in ultrasonic attenuation may be detectable, leading to an effective means of detecting cervical ripening. Herein, the traditional attenuation slope-estimation algorithm based on measuring the downshift in center frequency of the ultrasonic backscattered signal with propagation depth was modified and applied to the cervix of rats. The modified algorithm was verified using computer simulations and an …
Behavioral Effects Of Contraception Management: The Use Of Porcine Zona Pellucida On Wild Horses, Cassandra M.V. Nuñez
Behavioral Effects Of Contraception Management: The Use Of Porcine Zona Pellucida On Wild Horses, Cassandra M.V. Nuñez
Cassandra M.V. Nuñez
The advent of immunocontraception with porcine zona pellucida (PZP) has all but revolutionized wild horse management, providing a more humane method of population control than earlier strategies. Early studies on Assateague Island National Seashore have described it as an ideal form of fertility control in that it reduces the chance of conception to below 10%, can be delivered remotely, is reversible (after short-term use), lacks debilitating physiological side effects, cannot pass through the food chain, and shows minimal effects on social behaviors. However, recent research in other populations has revealed behavioral and physiological side effects of long-term PZP use. These …
Measuring The Dynamic Surface Accessibility Of Rna With The Small Paramagnetic Molecule Tempol, Vincenzo Venditti, Neri Niccolai, Samuel E. Butcher
Measuring The Dynamic Surface Accessibility Of Rna With The Small Paramagnetic Molecule Tempol, Vincenzo Venditti, Neri Niccolai, Samuel E. Butcher
Vincenzo Venditti
The surface accessibility of macromolecules plays a key role in modulating molecular recognition events. RNA is a complex and dynamic molecule involved in many aspects of gene expression. However, there are few experimental methods available to measure the accessible surface of RNA. Here, we investigate the accessible surface of RNA using NMR and the small paramagnetic molecule TEMPOL. We investigated two RNAs with known structures, one that is extremely stable and one that is dynamic. For helical regions, the TEMPOL probing data correlate well with the predicted RNA surface, and the method is able to distinguish subtle variations in atom …