Medicine and Health Sciences Commons^™

The Positive Functional And Structural Cardiovascular Impact Of Homoarginine In Aged Rats Via Modulation Of Cardiac Inos/Fibrosis Pathway And Ampk, Heba Fathy El-Domiaty, Walaa Abdellah Esa, Nesrin Abd Allah Salman

Menoufia Medical Journal

Objectives To investigate the cardiovascular protective effect of HA in aged rats and to clarify the underlying mechanisms. Background: Aging is a natural process, which has a gradual biological impact on the normal functions of different organs. Methods Thirty male Wistar rats were divided in to 3 groups: adult (4-6 months), aged (23-24 months) and aged HA supplemented groups. Systolic blood pressure (SBP), electrocardiogram (ECG) and aortic blood flow parameters were recorded for all rats. Then, rats were sacrificed and cardiac tissue was dissected to measure the cardiac levels of malondialdehyde (MDA), superoxide dismutase (SOD) and tumor necrosis factor-α (TNF-α). …

Ketogenic Diet, Caloric Restriction And Intermittent Fasting Increase The Mitochondrial Activity In Aged Rats, Mohamed H.A. Hassan, Hesham A.D. Abdel-Razek, Yahya M. Naguib, Eman A. Badr, Sara E. Abdou, Ahmed M. Gaafar

Menoufia Medical Journal

Objective: Studying the effect of multiple dietary strategies on mitochondrial activity of aged rats. Background: Healthy aging may be achieved by intermittent fasting, caloric restriction or ketogenic diet regimens. Material and methods: Thirty-two male Wistar rats, 20-22-week-old, were randomized into four equal groups: control, ketogenic diet (KD), caloric restriction (CR) and intermittent fasting (IF) groups. After 8 weeks, rats were weighed, and subjected for measurement of systolic blood pressure (SBP) using a rat-tail sphygmomanometer, and neurobehavioral assessment via open field examination. Then, fasting retro-orbital blood samples were collected to measure free fatty acids (FFA), liver and kidney function tests and …

Effect Of Type 2 Diabetes Milletus On Glycemic State, Cognitive Brain Functions And Hippocampus Dna In Adult Male Rats, Sohair A. Saleh, Gergess S. Hanna, Sobhy E. El-Naby, Suzy F. Ewieda, Rasha Sa. Elseadawy, Basma S. Ghoneim, Shaimaa M. Motawea

Menoufia Medical Journal

Objective: To investigate the impact of type 2 diabetes milletus on glycemic state, cognitive brain function, and hippocampus DNA in adult male rats as well as potential underlying mechanisms.

Background: It has been predicted that the number of diabetics will more than likely double by the year 2030 as a result of urbanization, obesity, and ageing. Diabetes mellitus is linked to the onset of dementia and Alzheimer's disease.

Methods: Thirty-six male albino rats of local strain, at 6 weeks of age weighing 150 - 200 gm each, were divided into 2 equal groups: non-Diabetic and Diabetic non-treated groups. After 4 …

Rutin Exerts Antidepressant Effect In A Rat Model Of Diabetes, Suzan A. Khodir, Eman A. Ali, Heba F. El-Domiaty

Menoufia Medical Journal

Objectives: to evaluate the potential antidepressant effect of rutin in diabetic rats and the assumed underlying mechanisms involved.

Background: Depression is a common behavioral disorder among diabetic patients. Oxidative stress and inflammation are strongly involved in pathophysiology of diabetes induced depression. Rutin is major flavonoid that is proved to have neuroprotective effect through antioxidant and anti-inflammatory effects.

Methods: Twenty four male Wistar rats were distributed (8/group) into control, diabetic and diabetic+Rutin groups. The depressive like behavior of the animals was conducted by forced swim test (FST). Fasting serum glucose, serum glycosylated hemoglobin A1c (Hb A1c), malondialdehyde (MDA), total antioxidant capacity, …

Knowledge, Attitude, And Practice Of Breast Self-Examination Among Women Attending Primary Health Care Facility, Menoufia Governorate, Egypt, Howida A. Al Shazly, Mahmoud A. Abo Salem, Reda A. Ibrahem, Shaimaa Yaihya Abd El-Roaf, Zeinab A. Kasemy

Menoufia Medical Journal

Objectives To evaluate the level of knowledge, attitude, and practice of breast self-examination (BSE) among female in childbearing period (18–49 years old) in Menoufia Governorate. Background BSE is a process whereby women examine their breasts regularly to detect any abnormal swelling or lumps to seek prompt medical attention. Breast cancer is the most common form of cancer among females in developed and developing countries. The early detection of breast cancer is the most important and beneficial area of protective techniques and has been positively linked with decrease of mortality and morbidity owing to the illness. Patients and methods A cross-sectional …