Medicine and Health Sciences Commons^™

Anti-Chaperone Activity And Cytotoxicity Of Chemical Components In Copaiba Oil, Daniel Kulman, Janine Naim, Bin Su Ph.D.

Undergraduate Research Posters 2013

Copaiba oil derived from the oleoresin of the Copaiba tree has been widely used as an antiseptic and expectorant for the respiratory tract, and as anti-inflammatory agent in various skin diseases. Studies have indicated that Copaiba oil exhibited anti-carcinogenic properties in various preclinical studies. However, the anti-cancer mechanisms of copaiba oil still remain unclear. There are various diterpenoid compounds within Copaiba oil, which also make the mechanism investigation very difficult. Hardwickiic acid (HAA), a clerodane diterpenoid isolated from Copaiba oil shows anti-chaperone activity from a recent study. In the current study, cytotoxicity and anti-chaperone assay guided isolation led to 9 …

Conceptualization And Design Of A Surface Translation Balance Training Device, Annie Djukic, Omri Tayyara, Deborah Espy, Majid Rashidi

Undergraduate Research Posters 2013

Research supports the idea that dynamic control of both a person's center of mass and base of support are necessary to prevent falls, and that older adults can learn this combined control through specific balance training. Effective balance training requires a large number of repetitions of task-specific practice. Externally induced movements have been employed in balance studies both to test and train balance responses, most often using mechanized surface perturbations. These systems however are quite expensive; therefore, we chose to investigate a more cost effective solution focusing on surface translation for balance training in our lab.

We performed a literature …

Controlling The Size And Shape Of Polypeptide Colloidal Particles: Temperature Dependence Of Particle Formation, John P. Gavin, Nolan B. Holland, Kiril A. Streletzky

Undergraduate Research Posters 2013

A promising approach for developing new drug delivery vehicles is by using stimuli responsive hydrogel nanoparticles. Polypeptide surfactants designed in our lab have been shown to form micellar particles of varying sizes and shapes depending on the solution salt concentration. These responsive polypeptide surfactants consist of a small charged protein domain (foldon) with three elastin-like polypeptide (ELP) chains forming a three-armed star polymer. The size and shape of the micelles they form is dependent on the ratio of total ELP volume to head group area. By introducing linear ELP into the ELP-foldon solution, the total volume of ELP in the …