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Full-Text Articles in Medicine and Health Sciences
Pharmacokinetics Of Famotidine In Goats After Intravenous Administration, Olivia Escher, Joseph Smith, Kamryn Christopher, Bryan Hogan, Lainey Harvill, Makenna Hopson, Sherry Cox
Pharmacokinetics Of Famotidine In Goats After Intravenous Administration, Olivia Escher, Joseph Smith, Kamryn Christopher, Bryan Hogan, Lainey Harvill, Makenna Hopson, Sherry Cox
Faculty Publications and Other Works -- Large Animal Clinical Sciences
No abstract provided.
Pharmacokinetics Of Esomeprazole In Goats (Capra Aegagrus Hircus) After Intravenous And Subcutaneous Administration, Rachel L. Fladung, Joseph Smith, Melissa Hines, Windy Soto-Gonzalez, Bryanna Fayne, Rebecca Rahn, Olivia Escher, Lainey Harvill, Joan Bergman, Jessica Garcia, Amanda Kreuder
Pharmacokinetics Of Esomeprazole In Goats (Capra Aegagrus Hircus) After Intravenous And Subcutaneous Administration, Rachel L. Fladung, Joseph Smith, Melissa Hines, Windy Soto-Gonzalez, Bryanna Fayne, Rebecca Rahn, Olivia Escher, Lainey Harvill, Joan Bergman, Jessica Garcia, Amanda Kreuder
Faculty Publications and Other Works -- Large Animal Clinical Sciences
Background: Stressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.
Objectives: The objectives for this study were to estimate plasma pharmacokinetic parameters for esomeprazole in adult goats after intravenous (IV) and subcutaneous (SQ) administration. A secondary objective was to describe the plasma kinetics of the metabolite esomeprazole sulfone after IV and SC administration in goats.
Materials and methods: Esomeprazole was administered to 5 adult goats in a crossover study at doses of 1 mg/kg IV or 2 mg/kg SC. …