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Immunological Effects Of Amphotericin B Desoxycholate And Liposomal Amphotericin B On Splenocytes From Immune-Normal And Immune-Compromised Mice, Jay Jenson Schindler

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Because of the increasing number of serious risk factors which predispose a normally immune competent host to infection, the incidence of systemic fungal infections is steadily increasing. This epidemiological rise has especially become apparent since the onset of the AIDS epidemic. Amphotericin B is the drug of choice for these life-threatening mycotic infections. Complications due to drug toxicity, however, severely limit amphotericin B's clinical usefulness. The major complication associated with the administration of amphotericin B is renal toxicity. Research has indicated, however, that besides its antifungal activities, amphotericin B may act as an immune stimulant of both humoral and cellular …