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An Examination Of Ms Candidate Genes Identified As Differentially Regulated In Multiple Sclerosis Plaque Tissue, Using Absolute And Comparative Real-Time Q-Pcr Analysis, L. Tajouri, A. Melllick, A. Tourtellotte, R. Nagra, L. Griffiths
An Examination Of Ms Candidate Genes Identified As Differentially Regulated In Multiple Sclerosis Plaque Tissue, Using Absolute And Comparative Real-Time Q-Pcr Analysis, L. Tajouri, A. Melllick, A. Tourtellotte, R. Nagra, L. Griffiths
Lotti Tajouri
In our laboratory, we have developed methods in real-time detection and quantitative-polymerase chain reaction (Q-PCR) to analyse the relative levels of gene expression in post mortem brain tissues. We have then applied this method to examine differences in gene activity between normal white matter (NWM) and plaque tissue from multiple sclerosis (MS) patients. Genes were selected based on their association with pathology and through identification by previously conducted global gene expression analysis. Plaque tissue was obtained from secondary progressive (SP) patients displaying chronic active, as well as acute pathologies; while NWM from the same location was obtained from age- and …
Variation In The Vitamin D Receptor Gene Is Associated With Multiple Sclerosis In An Austrlaian Population, Lotti Tajouri, Micky Ovcaric, Rob Curtain, Matthew Johnson, Lyn Griffiths, Peter Csurhes, Michael Pender, Rod Lea
Variation In The Vitamin D Receptor Gene Is Associated With Multiple Sclerosis In An Austrlaian Population, Lotti Tajouri, Micky Ovcaric, Rob Curtain, Matthew Johnson, Lyn Griffiths, Peter Csurhes, Michael Pender, Rod Lea
Lotti Tajouri
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, Tag I and Fok I) in an Australian MS case-control population. One hundred and four Australian MS patients were studied with patients classified clinically as Relapsing Remitting MS (RR-MS), Secondary Progressive MS (SP-MS) or Primary Progressive MS (PP-MS). Also, 104 age-, sex-, and ethnicity-matched controls were investigated as a comparative group. Our results show a significant difference of …