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Analysis Of Chromosome 1 Microsatellite Markers And The Fhm2-Atp1a2 Gene Mutations In Migraine Pedigrees, R. Curtain, R. Lea, L. Tajouri, L. Haupt, M. Ovcaric, J. Macmillan, L. Griffiths
Analysis Of Chromosome 1 Microsatellite Markers And The Fhm2-Atp1a2 Gene Mutations In Migraine Pedigrees, R. Curtain, R. Lea, L. Tajouri, L. Haupt, M. Ovcaric, J. Macmillan, L. Griffiths
Lotti Tajouri
Objectives: The aims of the study were: (i) to extend our linkage analysis of chromosome 1q microsatellite markers in predominately migraine with aura pedigrees and (ii) to test the novel FHM-2 ATP1A2 gene for involvement in these migraine affected pedigrees and a previous pedigree (MF14) showing evidence of linkage of markers to C1q31.
Methods: A chromosome 1 scan (31 markers) was performed in 21 multiplex pedigrees affected predominately with migraine with aura (MA). The known FHM-2 ATP1A2 gene mutations were tested, by sequencing, for the involvement in MA and migraine without aura (MO) in these pedigrees. Sequencing was performed in …