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Full-Text Articles in Medicine and Health Sciences
Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill
Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill
Jonathan Tan
No abstract provided.
Spleen Stroma Maintains Progenitors And Supports Long-Term Hematopoiesis, Helen O'Neill, Kristin Griffiths, Pravin Periasamu, Rebecca Hinton, Sawang Petvises, Ying-Ying Hey, Jonathan Tan
Spleen Stroma Maintains Progenitors And Supports Long-Term Hematopoiesis, Helen O'Neill, Kristin Griffiths, Pravin Periasamu, Rebecca Hinton, Sawang Petvises, Ying-Ying Hey, Jonathan Tan
Jonathan Tan
Hematopoietic stem/progenitor cells (HSPC) differentiate in the context of stromal niches producing cells of multiple lineages. Limited success has been achieved in the past with induction of hematopoiesis in vitro. Previously, spleen long-term stromal cultures (LTC) were shown to continuously support restricted hematopoiesis for production of novel dendritic-like cells (LTC-DC). An in vivo equivalent dendritic cell type was then described which is specific for spleen. The in vivo counterpart cell was termed 'L-DC' and represents a dendritic-like CD11cloCD11bhiCD8a-MHC-II- cell which differs phenotypically and functionally from monocytes/macrophages and conventional and plasmacytoid DC. Splenic stroma is now shown to maintain HSPC and …
Novel Splenic Antigen-Presenting Cells Derive From A Lin-C-Kitlo Progenitor, Pravin Periasamy, Jonathan Tan, Helen O'Neill
Novel Splenic Antigen-Presenting Cells Derive From A Lin-C-Kitlo Progenitor, Pravin Periasamy, Jonathan Tan, Helen O'Neill
Jonathan Tan
No abstract provided.