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Full-Text Articles in Medicine and Health Sciences
Hexosamine Biosynthesis Pathway Flux Contributes To Insulin Resistance Via Altering Membrane Phosphatidylinositol 4,5-Bisphosphate And Cortical Filamentous Actin, P. Bhonagiri, G. R. Pattar, E. M. Horvath, K. M. Habegger, Ann Mccarthy, J. S. Elmendorf
Hexosamine Biosynthesis Pathway Flux Contributes To Insulin Resistance Via Altering Membrane Phosphatidylinositol 4,5-Bisphosphate And Cortical Filamentous Actin, P. Bhonagiri, G. R. Pattar, E. M. Horvath, K. M. Habegger, Ann Mccarthy, J. S. Elmendorf
Ann Marie McCarthy
We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Here we delineated whether increased glucose flux through the hexosamine biosynthesis pathway (HBP) causes the PIP(2)/F-actin dysregulation and insulin resistance induced by hyperinsulinemia. Increased HBP activity was detected in 3T3-L1 adipocytes cultured under conditions closely resembling physiological hyperinsulinemia (5 nm insulin for 12 h) and in cells where HBP activity was amplified by 2 mm glucosamine (GlcN). Both the physiological hyperinsulinemia and experimental GlcN challenge induced comparable losses of PIP(2) and F-actin. In addition to protecting against …
A Policy Change Strategy For Head Lice Management, K. Andresen, Ann Mccarthy
A Policy Change Strategy For Head Lice Management, K. Andresen, Ann Mccarthy
Ann Marie McCarthy
The purpose of this project was to formulate an effective change strategy for head lice management in a group of five separate school districts within one county. Despite a desire to use evidence to support their practice, school nurses often encounter educational system barriers that prevent independent management of health conditions. The use of collaborative community relationships, identification of underlying hierarchy structures in school policy development, and targeted system education were the catalysts for changing beliefs and ultimately policy within these school districts. The focus of this project was to develop a policy change strategy for head lice. The strategy …