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Articles 1 - 10 of 10
Full-Text Articles in Medicine and Health Sciences
Influence Of Env And Long Terminal Repeat Sequences On The Tissue Tropism Of Avian Leukosis Viruses, David Brown, Harriet Robinson
Influence Of Env And Long Terminal Repeat Sequences On The Tissue Tropism Of Avian Leukosis Viruses, David Brown, Harriet Robinson
David C. Brown
Adsorption and penetration of retroviruses into eucaryotic cells is mediated by retroviral envelope glycoproteins interacting with host receptors. Recombinant avian leukosis viruses (ALVs) differing only in envelope determinants that interact with host receptors for subgroup A or E ALVs have been found to have unexpectedly distinctive patterns of tissue-specific replication. Recombinants of both subgroups were highly expressed in bursal lymphocytes as well as in cultured chicken embryo fibroblasts. In contrast, the subgroup A but not subgroup E host range allowed high levels of expression in skeletal muscle, while subgroup E but not subgroup A envelope glycoproteins permitted efficient replication in …
Physical Activity And Public Health: Training Courses For Researchers And Practitioners, David Brown, Russell Pate, Michale Pratt, Fran Wheeler, David Buchner, Barbara Ainsworth, Caroline Macera
Physical Activity And Public Health: Training Courses For Researchers And Practitioners, David Brown, Russell Pate, Michale Pratt, Fran Wheeler, David Buchner, Barbara Ainsworth, Caroline Macera
David C. Brown
No abstract provided.
Biomedical Research Leaders: Report On Needs, Opportunities, Difficulties, Education And Training, And Evaluation, Samuel Wilson, Deborah Brown, Jay Moskowitz, Dan Hurley, David Brown, David Brown, Byron Bailey, Michael Mcclain, Marilyn Misenhimer, Judith Buckalew, Thomas Burks
Biomedical Research Leaders: Report On Needs, Opportunities, Difficulties, Education And Training, And Evaluation, Samuel Wilson, Deborah Brown, Jay Moskowitz, Dan Hurley, David Brown, David Brown, Byron Bailey, Michael Mcclain, Marilyn Misenhimer, Judith Buckalew, Thomas Burks
David C. Brown
The National Association of Physicians for the Environment (NAPE) has assumed a leadership role in protecting environmental health in recent years. The Committee of Biomedical Research Leaders was convened at the recent NAPE Leadership Conference: Biomedical Research and the Environment held on 1–2 November 1999, at the National Institutes of Health, Bethesda, Maryland. This report summarizes the discussion of the committee and its recommendations. The charge to the committee was to raise and address issues that will promote and sustain environmental health, safety, and energy efficiency within the biomedical community. Leaders from every important research sector (industry laboratories, academic health …
The Effect Of All-Trans Retinoic Acid And Fatty Acids On Mcf-7 Breast Cancer Cell Progression, David Brown
The Effect Of All-Trans Retinoic Acid And Fatty Acids On Mcf-7 Breast Cancer Cell Progression, David Brown
David C. Brown
Vitamin A metabolites and retinoids may slow the progression of breast cancer and elicit anti-neoplastic properties similar to those of omega-3 fatty acids. Studies using animal models show a decrease in the incidence, growth and metastisis of mammary tumors in the presence of specific fatty acids. This effect is also seen with use of retinoids, specifically all-trans retinoic acid (AtRA). Thus, fatty acids may also alter retinoid homeostasis in mammary carcinoma cells (MCF-7s). The potential for inter/co dependency among fatty acids and retinoids is considerable, and here it has been hypothesized that a decrease in cancer progression will occur in …
Infection Of Peripancreatic Lymph Nodes But Not Islets Precedes Kilham Rat Virus-Induced Diabetes In Bb/Wor Rats, David Brown, Raymond Welsh, Arthur Like
Infection Of Peripancreatic Lymph Nodes But Not Islets Precedes Kilham Rat Virus-Induced Diabetes In Bb/Wor Rats, David Brown, Raymond Welsh, Arthur Like
David C. Brown
A parvovirus serologically identified as Kilham rat virus (KRV) reproducibly induces acute type I diabetes in diabetes-resistant BB/Wor rats. The tissue tropism of KRV was investigated by in situ hybridization with a digoxigenin-labelled plasmid DNA probe containing approximately 1.6 kb of the genome of the UMass isolate of KRV. Partial sequencing of the KRV probe revealed high levels of homology to the sequence of minute virus of mice (89%) and to the sequence of H1 (99%), a parvovirus capable of infecting rats and humans. Of the 444 bases sequenced, 440 were shared by H1. KRV mRNA and DNA were readily …
A Client-Based Description Of Reflecting Team-Work In Family Therapy , David Brown
A Client-Based Description Of Reflecting Team-Work In Family Therapy , David Brown
David C. Brown
Though the practice of reflecting team-work has a strong theoretical base there has been little research examining its actual use. What has been written is primarily based on the therapist's and/or supervisor's experience, rather than the client's. This dissertation describes clients' perceptions of two different strategies of reflecting team-work that emerged from interviews conducted and analyzed using a moderately structured ethnographic interview methodology. The primary results suggested that reflecting team-work was helpful in providing clients with different perspectives; that in-room teams should be used sparingly during early therapy; that teams should reflect at least twice in-session; and that a three-person …
Choosing A Fellow Or Fellowship: A Survey Of Pediatric Otolaryngologists, Robert Chun, Diego Preciado, David Brown, Ravindra Elluru, Stacey Ishman, Joseph Kerschner, Gresham Richter, Cecille Sulman
Choosing A Fellow Or Fellowship: A Survey Of Pediatric Otolaryngologists, Robert Chun, Diego Preciado, David Brown, Ravindra Elluru, Stacey Ishman, Joseph Kerschner, Gresham Richter, Cecille Sulman
David C. Brown
No abstract provided.
Gating Of The Polycystin Ion Channel Signaling Complex In Neurons And Kidney Cells, Patrick Delmas, Surya Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David Brown, Jing Zhou
Gating Of The Polycystin Ion Channel Signaling Complex In Neurons And Kidney Cells, Patrick Delmas, Surya Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David Brown, Jing Zhou
David C. Brown
Mutations in either polycystin-2 (PC2) or polycystin-1 (PC1) proteins cause severe, potentially lethal, kidney disorders and multiple extrarenal (including brain) disease phenotypes. PC2, a member of the transient receptor potential channel superfamily, and PC1, an orphan membrane receptor of largely unknown function, are thought to be part of a common signaling pathway. Here, we show that in rat sympathetic neurons and kidney cells, coassembly of full-length PC1 with PC2 forms a plasmalemmal ion channel signaling complex in which PC1 stimulation simultaneously activates PC2 ion channels and G(i/o)-proteins. PC2 activation occurs through a structural rearrangement of PC1, independent of G-protein activation. …
Building Capacity In Physical Activity And Public Health, Russell Pate, Jennifer Gay, David Brown, Michael Pratt
Building Capacity In Physical Activity And Public Health, Russell Pate, Jennifer Gay, David Brown, Michael Pratt
David C. Brown
No abstract provided.
Cd4+ Regulatory T Cells Require Ctla-4 For The Maintenance Of Systemic Tolerance, Randall Friedline, David Brown, Hai Nguyen, Hardy Kornfeld, Jinhee Lee, Yi Zhang, Mark Appleby, Sandy Der, Joonsoo Kang, Cynthia Chambers
Cd4+ Regulatory T Cells Require Ctla-4 For The Maintenance Of Systemic Tolerance, Randall Friedline, David Brown, Hai Nguyen, Hardy Kornfeld, Jinhee Lee, Yi Zhang, Mark Appleby, Sandy Der, Joonsoo Kang, Cynthia Chambers
David C. Brown
Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4-deficient mice develop fatal, early onset lymphoproliferative disease. However, chimeric mice containing both CTLA-4-deficient and -sufficient bone marrow (BM)-derived cells do not develop disease, indicating that CTLA-4 can act in trans to maintain T cell self-tolerance. Using genetically mixed blastocyst and BM chimaeras as well as in vivo T cell transfer systems, we demonstrate that in vivo regulation of Ctla4(-/-) T cells in trans by CTLA-4-sufficient T cells is …